NOX1 Human Protein

NOX1: NOH-1S is a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes and other tissues. It participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H(+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; EC 1.-.-.-; Motility/polarity/chemotaxis; Channel, misc.; Membrane protein, integral; Oxidoreductase

Chromosomal Location of Human Ortholog: Xq22

Cellular Component: early endosome; integral to membrane; cell junction; NADPH oxidase complex

Molecular Function: protein binding; superoxide-generating NADPH oxidase activity; metal ion binding; Rac GTPase binding; NADP binding; voltage-gated proton channel activity

Biological Process: intracellular pH elevation; respiratory burst; cell migration; extracellular matrix organization and biogenesis; positive regulation of smooth muscle cell proliferation; superoxide metabolic process; positive regulation of JNK cascade; signal transduction; NADP metabolic process; regulation of systemic arterial blood pressure by renin-angiotensin; proton transport; regulation of blood pressure; positive regulation of cell proliferation; hydrogen peroxide metabolic process; angiogenesis; positive regulation of integrin biosynthetic process; inflammatory response; superoxide release