NRF2 Protein

Name: NRF2 Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS8526848
Price: 430 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8526848

Background: domain: Acidic activation domain in the N-terminus, and DNA binding domain in the C-terminus.,function:Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated… More details

$430 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Nrf2, Protein

Full Product Name

Nrf2 protein

Product Gene Name

Nrf2 protein

Product Synonym Names

NFE2L2, NRF2, NFE2 like bZIP transcription factor 2, Nuclear factor erythroid 2-related factor 2 (NF-E2-related factor 2) (NFE2-related factor 2) (HEBP1) (Nuclear factor, erythroid derived 2, like 2)

Sequence

Amino acid: 11-130, with his-MBP tag. LPSQQDMDLI DILWRQDIDL GVSREVFDFS QRRKEYELEK QKKLEKERQE QLQKEQEKAF FAQLQLDEE TGEFLPIQPA QHIQSETSGS ANYSQVAHIP KSDALYFDDC M

Form/Format

Liquid in PBS ; 0.15 M Phosphate buffered saline, pH 7.4

Concentration

SDS-PAGE >90% (lot specific)

Preparation and Storage

Up to 1 year when aliquoted and stored at -20 to -80 °C.

OMIM

600492

3D Structure

ModBase 3D Structure for Q16236

Expression

E. coli

Vector and tag

C-His tag

Solubility

Soluble

Function

Transcription, transcription, DNA-dependent, regulation of transcription, DNA-dependent,transcription from RNA polymerase II promoter, ER-nuclear signaling pathway, response to unfolded protein, positive regulation of biosynthetic process, response to organic substance, positive regulation of macromolecule biosynthetic process,positive regulation of macromolecule metabolic process, positive regulation of gene expression, endoplasmic reticulum unfolded protein response, positive regulation of cellular biosynthetic process, RNA biosynthetic process, cellular response to stress, cellular response to unfolded protein, response to endoplasmic reticulum stress, regulation of transcription, positive regulation of transcription, DNA-dependent, positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process.

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of Nrf2 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Nrf2 purchase

MBS8526848 is a protein targeting Nrf2.

Additional Details

NCBI/Uniprot data below describe general gene information for Nrf2. It may not necessarily be applicable to this product.

NCBI GI #

224028257

NCBI GeneID

4780

NCBI Accession #

NP_001138884.1

UniProt Primary Accession #

Q16236

UniProt Secondary Accession #

Q53RW6; Q59HH2; Q96F71; B2RBU2; B4E338; E9PGJ7

UniProt Related Accession #

Q16236

GenBank Nucleotide #

NM_001145412.3

NCBI Official Full Name

nuclear factor erythroid 2-related factor 2 isoform 2

NCBI Official Synonym Full Names

nuclear factor, erythroid 2 like 2

NCBI Official Symbol

NFE2L2

NCBI Official Synonym Symbols

NRF2; HEBP1; IMDDHH

UniProt Protein Name

Nuclear factor erythroid 2-related factor 2

UniProt Synonym Protein Names

HEBP1; Nuclear factor, erythroid derived 2, like 2

Protein Family

Kelch-like ECH-associated protein

UniProt Gene Name

NFE2L2

UniProt Synonym Gene Names

NRF2; NF-E2-related factor 2; NFE2-related factor 2

NCBI Protein Information

nuclear factor erythroid 2-related factor 2

NCBI Summary for Nrf2

This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. [provided by RefSeq, Sep 2015]

UniProt Comments for Nrf2

Transcription activator that binds to antioxidant response (ARE) elements in the promoter regions of target genes. Important for the coordinated up-regulation of genes in response to oxidative stress. May be involved in the transcriptional activation of genes of the beta-globin cluster by mediating enhancer activity of hypersensitive site 2 of the beta-globin locus control region.

Research Articles on Nrf2

1. Studies indicate the effects of various modes of exercise on nuclear factor (erythroid-derived 2)-like 2 protein (Nrf2) signaling.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Nrf2 protein

Reference Product	PubMed Publications
KEAP1 protein	>511 publications with Nrf2 and KEAP1
JUN protein	>293 publications with Nrf2 and JUN
CASP3 protein	>83 publications with Nrf2 and CASP3
PPARG protein	>33 publications with Nrf2 and PPARG
NFE2 protein	>26 publications with Nrf2 and NFE2
MAFK protein	>24 publications with Nrf2 and MAFK
MAFG protein	>20 publications with Nrf2 and MAFG
ATF4 protein	>14 publications with Nrf2 and ATF4
JUND protein	>12 publications with Nrf2 and JUND
PMF1 protein	>7 publications with Nrf2 and PMF1

Pathways associated with Nrf2 protein

Products by Pathway	Pathway Diagram
AhR Pathway antibodies	AhR Pathway Diagram
Keap1-Nrf2 Pathway antibodies	Keap1-Nrf2 Pathway Diagram
Oxidative Stress Pathway antibodies	Oxidative Stress Pathway Diagram
Protein Processing In Endoplasmic Reticulum Pathway antibodies	Protein Processing In Endoplasmic Reticulum Pathway Diagram
Protein Processing In Endoplasmic Reticulum Pathway antibodies	Protein Processing In Endoplasmic Reticulum Pathway Diagram
Selenium Metabolism And Selenoproteins Pathway antibodies	Selenium Metabolism And Selenoproteins Pathway Diagram

Diseases associated with Nrf2 protein

Disease Name	Pubmed Publications
Neoplasms Antibodies	>434 publications with Nrf2 and Neoplasms
Drug Toxicity Antibodies	>399 publications with Nrf2 and Drug Toxicity
Inflammation Antibodies	>375 publications with Nrf2 and Inflammation
Disease Models, Animal Antibodies	>221 publications with Nrf2 and Disease Models, Animal
Nervous System Diseases Antibodies	>211 publications with Nrf2 and Nervous System Diseases
Necrosis Antibodies	>175 publications with Nrf2 and Necrosis
Liver Diseases Antibodies	>169 publications with Nrf2 and Liver Diseases
Brain Diseases Antibodies	>151 publications with Nrf2 and Brain Diseases
Liver Neoplasms Antibodies	>78 publications with Nrf2 and Liver Neoplasms
Gastrointestinal Diseases Antibodies	>70 publications with Nrf2 and Gastrointestinal Diseases

Organs/Tissues associated with Nrf2 protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>392 publications with Nrf2 and Liver
Blood Antibodies	>284 publications with Nrf2 and Blood
Lung Antibodies	>284 publications with Nrf2 and Lung
Brain Antibodies	>240 publications with Nrf2 and Brain
Vascular Antibodies	>194 publications with Nrf2 and Vascular
Muscle Antibodies	>136 publications with Nrf2 and Muscle
Kidney Antibodies	>127 publications with Nrf2 and Kidney
Heart Antibodies	>119 publications with Nrf2 and Heart
Skin Antibodies	>77 publications with Nrf2 and Skin
Nerve Antibodies	>60 publications with Nrf2 and Nerve