PI2R Human Protein

Name: PI2R Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1880198
Price: 1320 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1880198

The protein encoded by this gene is a member of the G-protein coupled receptor family 1 and has been shown to be a receptor for prostacyclin. Prostacyclin, the major product of cyclooxygenase in macrovascular endothelium, elicits a potent vasodilation and… More details

$1320 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

PI2R, Protein

Full Product Name

Human PI2R full length protein-synthetic nanodisc

Product Gene Name

PI2R protein

Product Synonym Names

IP; PRIPR

Host

HEK293

Form/Format

Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.

Preparation and Storage

Store at -20 degree C to -80 degree C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80 degree C (Avoid repeated freezing and thawing).

Molecular Weight

40,956 Da

Chromosome Location

Chromosome: 19; NC_000019.9 (47123725..47128354, complement). Location: 19q13.3

OMIM

600022

3D Structure

ModBase 3D Structure for P43119

Product Categories/Family for PI2R protein

FLP 489; Full Length Transmembrane Proteins

Other Notes

Small volumes of PI2R protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PI2R purchase

MBS1880198 is a protein targeting PI2R. Also known as Human PI2R full length protein-synthetic nanodisc. Host: HEK293.

Additional Details

NCBI/Uniprot data below describe general gene information for PI2R. It may not necessarily be applicable to this product.

NCBI GI #

4506263

NCBI GeneID

5739

NCBI Accession #

NP_000951.1

UniProt Primary Accession #

P43119

UniProt Related Accession #

P43119

GenBank Nucleotide #

NM_000960.3

NCBI Official Full Name

prostacyclin receptor

NCBI Official Synonym Full Names

prostaglandin I2 (prostacyclin) receptor (IP)

NCBI Official Symbol

PTGIR

NCBI Official Synonym Symbols

IP; PRIPR

UniProt Protein Name

Prostacyclin receptor

UniProt Synonym Protein Names

Prostaglandin I2 receptor; PGI receptor; PGI2 receptor; Prostanoid IP receptor

UniProt Gene Name

PTGIR

UniProt Synonym Gene Names

PRIPR; PGI receptor

UniProt Entry Name

PI2R_HUMAN

NCBI Protein Information

prostacyclin receptor; PGI receptor; PGI2 receptor; prostanoid IP receptor; prostaglandin I2 receptor

UniProt Comments for PI2R

PTGIR: Receptor for prostacyclin (prostaglandin I2 or PGI2). The activity of this receptor is mediated by G(s) proteins which activate adenylate cyclase. Belongs to the G-protein coupled receptor 1 family.

Protein type: Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: integral to plasma membrane; plasma membrane; cytosol

Molecular Function: G-protein coupled receptor activity; guanyl-nucleotide exchange factor activity

Biological Process: G-protein signaling, coupled to cyclic nucleotide second messenger; cell-cell signaling; negative regulation of smooth muscle cell proliferation; positive regulation of cAMP biosynthetic process; response to lipopolysaccharide; blood coagulation; G-protein signaling, adenylate cyclase activating pathway; positive regulation of GTPase activity

Research Articles on PI2R

1. these data provide critical insights into the transcriptional regulation of the human prostacyclin receptor gene within the vasculature, including during megakaryocytic differentiation

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with PI2R protein

Products by Pathway	Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Eicosanoid Ligand-binding Receptors Pathway antibodies	Eicosanoid Ligand-binding Receptors Pathway Diagram
Endothelin Pathway antibodies	Endothelin Pathway Diagram
G Alpha (s) Signalling Events Pathway antibodies	G Alpha (s) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
GPCRs, Class A Rhodopsin-like Pathway antibodies	GPCRs, Class A Rhodopsin-like Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with PI2R protein

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>15 publications with PI2R and Cardiovascular Diseases
Vascular Diseases Antibodies	>12 publications with PI2R and Vascular Diseases
Inflammation Antibodies	>12 publications with PI2R and Inflammation
Hypertension Antibodies	>8 publications with PI2R and Hypertension
Pain Antibodies	>5 publications with PI2R and Pain
Neoplasms Antibodies	>4 publications with PI2R and Neoplasms
Atherosclerosis Antibodies	>4 publications with PI2R and Atherosclerosis
Heart Diseases Antibodies	>4 publications with PI2R and Heart Diseases
Necrosis Antibodies	>3 publications with PI2R and Necrosis
Hypertrophy Antibodies	>2 publications with PI2R and Hypertrophy

Organs/Tissues associated with PI2R protein

Organ/Tissue Name	Pubmed Publications
Vascular Antibodies	>30 publications with PI2R and Vascular
Blood Antibodies	>21 publications with PI2R and Blood
Kidney Antibodies	>8 publications with PI2R and Kidney
Lung Antibodies	>5 publications with PI2R and Lung
Skin Antibodies	>2 publications with PI2R and Skin
Brain Antibodies	>1 publications with PI2R and Brain
Connective Tissue Antibodies	>1 publications with PI2R and Connective Tissue
Embryonic Tissue Antibodies	>1 publications with PI2R and Embryonic Tissue
Spleen Antibodies	>1 publications with PI2R and Spleen
Placenta Antibodies	>1 publications with PI2R and Placenta