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PROKR1 Human Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS189859

A member of the G-protein-coupled receptor family. The encoded protein binds to prokineticins (1 and 2), leading to the activation of MAPK and STAT signaling pathways. Prokineticins are protein ligands involved in angiogenesis and inflammation. The encoded… More details

$1320 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PROKR1, Protein
Full Product Name
Human PROKR1 full length protein-synthetic nanodisc
Product Gene Name
PROKR1 protein
Product Synonym Names
GPR73; GPR73a; PK-R1; PKR1; ZAQ
Host
HEK293
Form/Format
Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.
Preparation and Storage
Store at -20 degree C to -80 degree C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80 degree C (Avoid repeated freezing and thawing).
Molecular Weight
44,770 Da
Chromosome Location
Chromosome: 2; NC_000002.11 (68872954..68882708). Location: 2p13.1
OMIM
607122
3D Structure
ModBase 3D Structure for Q8TCW9

Product Categories/Family for PROKR1 protein

FLP 489; Full Length Transmembrane Proteins

ELISA (EIA) of PROKR1 protein

Figure1. Elisa plates were pre-coated with DYKDDDDK Tag PROKR1-Nanodisc (0.2ug/per well). Serial diluted anti-DYKDDDDK monoclonal antibody solutions were added, washed, and incubated with secondary antibody before Elisa reading. From above data, the EC50 for anti-DYKDDDDK monoclonal antibody binding with PROKR1-Nanodisc is 6.323ng/ml.
Human PROKR1 Protein – Cat# MBS189859

SDS-Page of PROKR1 protein

Figure1. Elisa plates were pre-coated with DYKDDDDK Tag PROKR1-Nanodisc (0.2ug/per well). Serial diluted anti-DYKDDDDK monoclonal antibody solutions were added, washed, and incubated with secondary antibody before Elisa reading. From above data, the EC50 for anti-DYKDDDDK monoclonal antibody binding with PROKR1-Nanodisc is 6.323ng/ml.
Human PROKR1 Protein, SDS-Page – Cat# MBS189859

Other Notes

Small volumes of PROKR1 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PROKR1 purchase

MBS189859 is a protein targeting PROKR1. Also known as Human PROKR1 full length protein-synthetic nanodisc. Host: HEK293.

Additional Details

NCBI/Uniprot data below describe general gene information for PROKR1. It may not necessarily be applicable to this product.

NCBI GI #
20373179
NCBI GeneID
10887
NCBI Accession #
NP_620414.1
UniProt Primary Accession #
Q8TCW9
UniProt Secondary Accession #
Q53QT9; Q8NFJ7; A5JUU2
UniProt Related Accession #
Q8TCW9
GenBank Nucleotide #
NM_138964.2
NCBI Official Full Name
prokineticin receptor 1
NCBI Official Synonym Full Names
prokineticin receptor 1
NCBI Official Symbol
PROKR1
NCBI Official Synonym Symbols
ZAQ; PKR1; GPR73; GPR73a
UniProt Protein Name
Prokineticin receptor 1
UniProt Synonym Protein Names
G-protein coupled receptor 73; G-protein coupled receptor ZAQ; GPR73a
Protein Family
Prokineticin receptor
UniProt Gene Name
PROKR1
UniProt Synonym Gene Names
GPR73; PKR1; PK-R1
UniProt Entry Name
PKR1_HUMAN
NCBI Protein Information
prokineticin receptor 1; PK-R1; G protein-coupled receptor 73; G-protein coupled receptor 73; G protein-coupled receptor ZAQ; G-protein coupled receptor ZAQ

UniProt Comments for PROKR1

PROKR1: Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2p13.1

Cellular Component: plasma membrane; integral to membrane

Molecular Function: neuropeptide Y receptor activity

Biological Process: neuropeptide signaling pathway; negative regulation of apoptosis
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Research Articles on PROKR1

1. hCG increases EG-VEGF, PROKR1 and PROKR2 mRNA and protein expression in a dose- and time-dependent manner, demonstrating a new role for hCG in the regulation of EG-VEGF and its receptors

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with PROKR1 protein

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies  Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By GPCR Pathway antibodies  Signaling By GPCR Pathway Diagram

Diseases associated with PROKR1 protein

 Disease Name  Pubmed Publications
 Pain Antibodies  >6 publications with PROKR1 and Pain
 Neoplasms Antibodies  >4 publications with PROKR1 and Neoplasms
 Nervous System Diseases Antibodies  >3 publications with PROKR1 and Nervous System Diseases
 Inflammation Antibodies  >3 publications with PROKR1 and Inflammation
 Vascular Diseases Antibodies  >3 publications with PROKR1 and Vascular Diseases
 Hyperalgesia Antibodies  >3 publications with PROKR1 and Hyperalgesia
 Liver Diseases Antibodies  >1 publications with PROKR1 and Liver Diseases
 Liver Cirrhosis, Experimental Antibodies  >1 publications with PROKR1 and Liver Cirrhosis, Experimental
 Cardiomegaly Antibodies  >1 publications with PROKR1 and Cardiomegaly
 Fibrosis Antibodies  >1 publications with PROKR1 and Fibrosis

Organs/Tissues associated with PROKR1 protein

 Organ/Tissue Name  Pubmed Publications
 Testis Antibodies  >4 publications with PROKR1 and Testis
 Brain Antibodies  >4 publications with PROKR1 and Brain
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