RXFP2 Human Protein

Name: RXFP2 Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1880210
Price: 1320 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1880210

This gene encodes a member of the GPCR (G protein-coupled, 7-transmembrane receptor) family. Mutations in this gene are associated with cryptorchidism. Alternatively spliced transcript variants encoding different isoforms have been found for this… More details

$1320 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

RXFP2, Protein

Full Product Name

Human RXFP2 full length protein-synthetic nanodisc

Product Gene Name

RXFP2 protein

Product Synonym Names

GPR106; GREAT; INSL3R; LGR8; LGR8.1; RXFPR2

Host

HEK293

Form/Format

Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.

Preparation and Storage

Store at -20 degree C to -80 degree C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80 degree C (Avoid repeated freezing and thawing).

Molecular Weight

86,453 Da

Chromosome Location

Chromosome: 13; NC_000013.10 (32313679..32377009). Location: 13q13.1

OMIM

219050

3D Structure

ModBase 3D Structure for Q8WXD0

Product Categories/Family for RXFP2 protein

FLP 489; Full Length Transmembrane Proteins

Other Notes

Small volumes of RXFP2 protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RXFP2 purchase

MBS1880210 is a protein targeting RXFP2. Also known as Human RXFP2 full length protein-synthetic nanodisc. Host: HEK293.

Additional Details

NCBI/Uniprot data below describe general gene information for RXFP2. It may not necessarily be applicable to this product.

NCBI GI #

260593673

NCBI GeneID

122042

NCBI Accession #

NP_001159530.1

UniProt Primary Accession #

Q8WXD0

UniProt Secondary Accession #

Q3KU23; B1ALE9

UniProt Related Accession #

Q8WXD0

GenBank Nucleotide #

NM_001166058.1

NCBI Official Full Name

relaxin receptor 2 isoform 2

NCBI Official Synonym Full Names

relaxin/insulin-like family peptide receptor 2

NCBI Official Symbol

RXFP2

NCBI Official Synonym Symbols

LGR8; GREAT; GPR106; INSL3R; LGR8.1; RXFPR2

UniProt Protein Name

Relaxin receptor 2

UniProt Synonym Protein Names

G-protein coupled receptor 106; G-protein coupled receptor affecting testicular descent; Leucine-rich repeat-containing G-protein coupled receptor 8; Relaxin family peptide receptor 2

Protein Family

Relaxin receptor

UniProt Gene Name

RXFP2

UniProt Synonym Gene Names

GPR106; GREAT; LGR8

UniProt Entry Name

RXFP2_HUMAN

NCBI Protein Information

relaxin receptor 2; G-protein coupled receptor 106; relaxin family peptide receptor 2; G protein coupled receptor affecting testicular descent; G-protein coupled receptor affecting testicular descent; leucine-rich repeat-containing G protein-coupled recep

UniProt Comments for RXFP2

LGR8: the relaxin receptor is a G-protein coupled receptor (GPCR) that leads to the stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3).

Protein type: Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1; Receptor, GPCR

Chromosomal Location of Human Ortholog: 13q13.1

Cellular Component: integral to membrane; plasma membrane

Molecular Function: peptide hormone binding; protein-hormone receptor activity

Biological Process: negative regulation of cell proliferation; positive regulation of cAMP biosynthetic process; male gonad development; G-protein signaling, adenylate cyclase inhibiting pathway; G-protein signaling, adenylate cyclase activating pathway; oocyte maturation; negative regulation of apoptosis

Disease: Cryptorchidism, Unilateral Or Bilateral

Research Articles on RXFP2

1. These results provide new mechanistic insights into the binding and activation events of RXFP1 and RXFP2 by their native hormone ligands.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with RXFP2 protein

Reference Product	PubMed Publications
INSL3 protein	>79 publications with RXFP2 and INSL3
RLN2 protein	>11 publications with RXFP2 and RLN2

Pathways associated with RXFP2 protein

Products by Pathway	Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
G Alpha (s) Signalling Events Pathway antibodies	G Alpha (s) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
Myometrial Relaxation And Contraction Pathways antibodies	Myometrial Relaxation And Contraction Pathways Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Peptide Ligand-binding Receptors Pathway antibodies	Peptide Ligand-binding Receptors Pathway Diagram
Relaxin Receptors Pathway antibodies	Relaxin Receptors Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram

Diseases associated with RXFP2 protein

Disease Name	Pubmed Publications
Cryptorchidism Antibodies	>35 publications with RXFP2 and Cryptorchidism
Fibrosis Antibodies	>6 publications with RXFP2 and Fibrosis
Pregnancy Complications Antibodies	>3 publications with RXFP2 and Pregnancy Complications
Cardiovascular Diseases Antibodies	>2 publications with RXFP2 and Cardiovascular Diseases
Thyroid Neoplasms Antibodies	>2 publications with RXFP2 and Thyroid Neoplasms
Prenatal Exposure Delayed Effects Antibodies	>2 publications with RXFP2 and Prenatal Exposure Delayed Effects
Weight Loss Antibodies	>1 publications with RXFP2 and Weight Loss
Carcinoma, Hepatocellular Antibodies	>1 publications with RXFP2 and Carcinoma, Hepatocellular
Hyperplasia Antibodies	>1 publications with RXFP2 and Hyperplasia