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SCN2B Human Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1883071

The protein encoded by this gene is the beta 2 subunit of the type II voltage-gated sodium channel. The encoded protein is involved in cell-cell adhesion and cell migration. Defects in this gene can be a cause of Brugada Syndrome, atrial fibrillation, or… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
SCN2B, Protein
Full Product Name
Human SCN2B full length protein-synthetic nanodisc
Product Gene Name
Product Synonym Names
ATFB14
Host
HEK293
Form/Format
Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5%-8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions. Do not use solvents with pH lower
Preparation and Storage
Store at -20 degree C to -80 degree C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80 degree C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Molecular Weight
24,326 Da
Chromosome Location
Chromosome: 11; NC_000011.9 (118033519..118047337, complement). Location: 11q23
OMIM
601327
3D Structure
ModBase 3D Structure for O60939
Tag
C-DYKDDDDK

Other Notes

Small volumes of SCN2B protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SCN2B purchase

MBS1883071 is a protein targeting SCN2B. Also known as Human SCN2B full length protein-synthetic nanodisc. Host: HEK293.

Additional Details

NCBI/Uniprot data below describe general gene information for SCN2B. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
sodium channel subunit beta-2
NCBI Official Synonym Full Names
sodium channel, voltage-gated, type II, beta subunit
NCBI Official Symbol
SCN2B
UniProt Protein Name
Sodium channel subunit beta-2
Protein Family
UniProt Gene Name
SCN2B
UniProt Entry Name
SCN2B_HUMAN
NCBI Protein Information
sodium channel subunit beta-2; sodium channel beta 2 subunit; neuronal voltage-gated sodium channel beta 2 subunit; sodium channel, voltage-gated, type II, beta polypeptide

UniProt Comments for SCN2B

SCN2B: Crucial in the assembly, expression, and functional modulation of the heterotrimeric complex of the sodium channel. The subunit beta-2 causes an increase in the plasma membrane surface area and in its folding into microvilli. Interacts with TNR may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. Belongs to the sodium channel auxiliary subunit SCN2B (TC 8.A.17) family.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q23

Cellular Component: voltage-gated sodium channel complex

Molecular Function: sodium channel regulator activity

Biological Process: nervous system development; synaptic transmission; cardiac muscle contraction; response to pyrethroid

Disease: Atrial Fibrillation, Familial, 14
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SCN2B protein

 Reference Product  PubMed Publications
 SCN1B protein  >16 publications with SCN2B and SCN1B

Organs/Tissues associated with SCN2B protein

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