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Transferrin Receptor (TFR) Eukaryotic Protein

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2124304
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MBS2124304 is a protein targeting TFR. Also known as Eukaryotic Transferrin Receptor (TFR). Host: 293F cells. More details

$225 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Transferrin Receptor (TFR), Protein
Full Product Name
Eukaryotic Transferrin Receptor (TFR)
Product Gene Name
TFR protein
Product Synonym Names
Transferrin Receptor; CD71; TFR1; P90; TFRC; T9; Trfr; sTfR; Transferrin receptor protein 1, serum form
Sequence
Cys89~Phe7 60
Host
293F cells
Form/Format
Freeze-dried powder
20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
Purity/Purification
>90%
Preparation and Storage
Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months. Avoid repeated freeze/thaw cycles.
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 degree C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Matching Pairs
Antibody: TFR Clone #C5 (MBS2153102)
Immunogen: TFR (MBS2124304)
Molecular Weight
84,871 Da
Chromosome Location
Chromosome: 3; NC_000003.11 (195776155..195809032, complement). Location: 3q29
OMIM
190010
3D Structure
ModBase 3D Structure for P02786
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Source
Eukaryotic expression
Species
Human
Tag
N-terminal His Tag
Endotoxin
<1.0EU per 1ug (determined by the LAL method)
Isoelectric Point
6.8
Subcellular Location
Secreted
Usage
Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

Product Categories/Family for TFR protein

Signal transduction; CD & Adhesion molecule; Tumor immunity; Infection immunity; Eukaryotic proteins/EP
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for TFR protein
Positive Control, Immunogen, SDS-PAGE, Western Blot (WB)

Sequence Information of TFR protein

Eukaryotic TFR Protein – Cat# MBS2124304

SDS-Page of TFR protein

Figure. SDS-PAGE
Eukaryotic TFR Protein, SDS-Page – Cat# MBS2124304

Other Notes

Small volumes of TFR protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for TFR. It may not necessarily be applicable to this product.

NCBI GI #
189458819
NCBI GeneID
7037
NCBI Accession #
NP_001121620.1
UniProt Primary Accession #
P02786
UniProt Secondary Accession #
Q1HE24; Q59G55; Q9UCN0; Q9UCU5; Q9UDF9; Q9UK21; D3DXB0
UniProt Related Accession #
P02786
GenBank Nucleotide #
NM_001128148.1
NCBI Official Full Name
transferrin receptor protein 1
NCBI Official Synonym Full Names
transferrin receptor (p90, CD71)
NCBI Official Symbol
TFRC
NCBI Official Synonym Symbols
T9; TR; TFR; p90; CD71; TFR1; TRFR
UniProt Protein Name
Transferrin receptor protein 1
UniProt Synonym Protein Names
T9; p90
UniProt Gene Name
TFRC
UniProt Synonym Gene Names
TR; TfR; TfR1; Trfr; sTfR
UniProt Entry Name
TFR1_HUMAN
NCBI Protein Information
transferrin receptor protein 1

UniProt Comments for TFR

TfR: the transferrin receptor. Regulates the cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied receptors into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system.

Protein type: Membrane protein, integral; Receptor, misc.; Cell surface

Chromosomal Location of Human Ortholog: 3q29

Cellular Component: extracellular space; cell surface; intracellular membrane-bound organelle; integral to plasma membrane; cytoplasmic membrane-bound vesicle; extracellular region; coated pit; recycling endosome; membrane; perinuclear region of cytoplasm; melanosome; plasma membrane; vesicle; endosome; external side of plasma membrane

Molecular Function: identical protein binding; protein binding; transferrin receptor activity; double-stranded RNA binding

Biological Process: receptor-mediated endocytosis; viral reproduction; cellular iron ion homeostasis; positive regulation of bone resorption; transferrin transport; osteoclast differentiation; regulation of cell growth; transmembrane transport; regulation of cell proliferation
Show more

Research Articles on TFR

1. TfR1 N-terminal fragment is a substrate for intramembrane proteolysis by SPPL2b.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with TFR protein

 Reference Product  PubMed Publications
 HFE protein  >18 publications with TFR and HFE
 CD4 protein  >1 publications with TFR and CD4

Pathways associated with TFR protein

 Products by Pathway  Pathway Diagram
 Clathrin Derived Vesicle Budding Pathway antibodies  Clathrin Derived Vesicle Budding Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Golgi Associated Vesicle Biogenesis Pathway antibodies  Golgi Associated Vesicle Biogenesis Pathway Diagram
 HIF-1 Signaling Pathway antibodies  HIF-1 Signaling Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Iron Metabolism In Placenta Pathway antibodies  Iron Metabolism In Placenta Pathway Diagram

Diseases associated with TFR protein

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >33 publications with TFR and Neoplasms
 Iron Metabolism Disorders Antibodies  >28 publications with TFR and Iron Metabolism Disorders
 Anemia Antibodies  >16 publications with TFR and Anemia
 Disease Models, Animal Antibodies  >11 publications with TFR and Disease Models, Animal
 Anemia, Iron-Deficiency Antibodies  >8 publications with TFR and Anemia, Iron-Deficiency
 Lung Neoplasms Antibodies  >7 publications with TFR and Lung Neoplasms
 Liver Diseases Antibodies  >6 publications with TFR and Liver Diseases
 Brain Diseases Antibodies  >5 publications with TFR and Brain Diseases
 Breast Neoplasms Antibodies  >4 publications with TFR and Breast Neoplasms
 Drug Toxicity Antibodies  >4 publications with TFR and Drug Toxicity

Organs/Tissues associated with TFR protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >34 publications with TFR and Blood
 Liver Antibodies  >22 publications with TFR and Liver
 Brain Antibodies  >16 publications with TFR and Brain
 Intestine Antibodies  >11 publications with TFR and Intestine
 Lung Antibodies  >10 publications with TFR and Lung
 Bone Antibodies  >8 publications with TFR and Bone
 Skin Antibodies  >7 publications with TFR and Skin
 Kidney Antibodies  >7 publications with TFR and Kidney
 Embryonic Tissue Antibodies  >6 publications with TFR and Embryonic Tissue
 Prostate Antibodies  >5 publications with TFR and Prostate
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