Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. Binds to dvl2 and regulates the degradation of ctnnb1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. May also bind to and directly stimulate the activity of tcf7l1 ().

Also known as Dapper 1-A (Dapper1b) (XDpr1b) (Functional regulator of dsh in ontogenesis) (Frodo).
Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. Binds to dvl2/dsh and impedes the degradation of beta-catenin (ctnnb1-A and possibly ctnnb1-B), thereby enhancing the transcriptional activation of target genes of the Wnt signaling pathway. Also promotes catenin delta/ctnnd1 stability which in turn promotes zbtb33/kaiso sequestration and thus is involved in the regulation of zbtb33/kaiso-mediated transcriptional repression. May also bind to and directly stimulate the transcriptional activity of tcf7l1-A. Required for eye development and neural patterning.

Also known as Dapper 1-B (xDpr) (Dapper1a) (XDpr1a).
Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. Binds to dvl2 to regulate the degradation of beta-catenin (ctnnb1-A and possibly ctnnb1-B), thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. Seems to promote beta-catenin degradation if not phosphorylated and to block beta-catenin degradation if phosphorylated by CaMK1D. Involved in regulation of catenin delta/ctnnd1 protein level. May also bind to and directly stimulate the activity of tcf7l1-A. Also regulates the activation by dvl2 of jnk, a component of ctnnb1/beta-catenin-independent frizzled signaling. Required for notochord and head formation.

Also known as Dapper homolog 1 (Dapper antagonist of catenin 1) (Frodo homolog) (MDpr1) (Thymus-expressed novel gene 3 protein).
DACT1: Positively regulates DVL2-mediated signaling pathways during development. Binds to DVL2 and impedes the degradation of CTNNB1/beta-catenin, thereby enhancing the transcriptional activation of target genes of the Wnt signaling pathway. Interacts with DVL1 and DVL2. Belongs to the dapper family.

Protein type: Adaptor/scaffold

Cellular Component: beta-catenin destruction complex; cytoplasm; nucleoplasm; nucleus

Molecular Function: beta-catenin binding; histone deacetylase binding; protein binding; protein kinase A binding; protein kinase C binding

Biological Process: dendrite morphogenesis; embryonic hindgut morphogenesis; embryonic morphogenesis; gastrulation with mouth forming second; negative regulation of JNK cascade; negative regulation of protein binding; negative regulation of transcription from RNA polymerase II promoter; negative regulation of Wnt receptor signaling pathway; neural tube development; positive regulation of fat cell differentiation; positive regulation of protein binding; positive regulation of protein catabolic process; positive regulation of Wnt receptor signaling pathway; regulation of protein stability; synapse organization and biogenesis; Wnt receptor signaling pathway through beta-catenin

Also known as Dapper homolog 2 (Dapper antagonist of catenin 2).
DACT2: Involved in regulation of intracellular signaling pathways during development. Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors, such as TGFBR1. May be involved in control of the morphogenetic behavior of kidney ureteric bud cells by keeping cells epithelial and restraining their mesenchymal character. May play an inhibitory role in the re-epithelialization of skin wounds by attenuating TGF-beta signaling. Belongs to the dapper family. 4 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 6q27

Cellular Component: cytoplasm

Molecular Function: beta-catenin binding; protein kinase A binding; protein kinase C binding; transcription factor binding

Biological Process: negative regulation of cell adhesion; regulation of Wnt receptor signaling pathway; skin development

Also known as Dapper homolog 3 (Antagonist of beta-catenin Dapper homolog 3) (Arginine-rich region 1 protein) (Dapper antagonist of catenin 3).
DACT3: May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. Belongs to the dapper family.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 19q13.32

Cellular Component: cytoplasm

Molecular Function: beta-catenin binding; protein kinase A binding; protein kinase C binding

Biological Process: negative regulation of cell growth; negative regulation of Wnt receptor signaling pathway