Also known as Microcin C7 (MccC7) (Microcin C51) (McC) (MccC51) (Microcin C).
Antibacterial peptide, active against enterobacteria including species of Klebsiella, Salmonella, Shigella, Yersinia and Proteus, and strains of E.coli. Inhibits protein translation by blocking aspartyl-tRNA synthetase function and inhibiting production of aminoacetylated tRNA-Asp.

Also known as Microcin E492 (MccE492).
Channel-forming bacteriocin. Forms cation-selective channels. Active on enterobacteria, with highest activity against E.coli. Not active on other Gram-negative bacteria, Gram-positive bacteria or fungi. The unmodified protein is active against E.coli and S.enteritidis. When the siderophore ester is present at Ser-99, antibacterial activity against these species is increased and activity is also detected against E.cloacae and K.pneumoniae.

Also known as Microcin H47 (MccH47).
Bactericidal antibiotic. Active on bacteria phylogenetically related to the producing strain.

Also known as Microcin J25 (MccJ25).
Peptide antibiotic that functions through inhibition of the bacterial DNA-dependent RNA polymerase (RNAP). May inhibit transcription by binding in RNAP secondary channel and blocking nucleotide substrates access to the catalytic center. Exhibits potent bacteriocidal activity against a range of Enterobacteriaceae, including several pathogenic E.coli, Salmonella and Shigella strains. Also acts on the cytoplasmic membrane of Salmonella newport, producing alteration of membrane permeability and disruption of the subsequent gradient dissipation, which inhibits several processes essential for cell viability, such as oxygen consumption. Induces bacterial filamentation in susceptible cells in a non-SOS-dependent way, but this phenotype may result from impaired transcription of genes coding for cell division proteins.

Also known as Microcin-24 (Mcc24).
Channel-forming bacteriocin.