CD36 ELISA Kit for Rat

CD36: Binds to collagen, thrombospondin, anionic phospholipids and oxidized low-density lipoprotein (oxLDL). May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport (By similarity). Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects (By similarity). As a coreceptor for TLR4-TLR6, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42 binding, rapidly induces the formation of a heterodimer of TLR4 and TLR6, which is internalized and triggers inflammatory signals, leading to the NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion

Protein type: Membrane protein, integral; Cell adhesion; Membrane protein, multi-pass

Cellular Component: apical part of cell; apical plasma membrane; brush border membrane; caveola; cell surface; cytosol; endoplasmic reticulum; external side of plasma membrane; extracellular space; Golgi apparatus; integral to membrane; intracellular; intracellular membrane-bound organelle; lipid raft; membrane; mitochondrion; plasma membrane; protein complex; sarcolemma

Molecular Function: high-density lipoprotein binding; lipid binding; low-density lipoprotein binding; low-density lipoprotein receptor activity; protein binding; transforming growth factor beta binding

Biological Process: apoptotic cell clearance; cell adhesion; cell surface receptor linked signal transduction; cellular response to insulin stimulus; cGMP-mediated signaling; cholesterol absorption; cholesterol transport; defense response to Gram-positive bacterium; elevation of cytosolic calcium ion concentration; fatty acid metabolic process; fatty acid oxidation; fatty acid transport; gut development; interleukin-1 beta secretion; intestinal absorption; lipoprotein transport; long-chain fatty acid metabolic process; long-chain fatty acid transport; low density lipoprotein mediated signaling; negative regulation of angiogenesis; negative regulation of systemic arterial blood pressure; negative regulation of transcription factor import into nucleus; negative regulation of transcription from RNA polymerase II promoter; nitric oxide mediated signal transduction; phagocytosis, recognition; positive regulation of blood coagulation; positive regulation of cell-matrix adhesion; positive regulation of cytokine secretion; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-12 production; positive regulation of interleukin-6 production; positive regulation of MAPKKK cascade; positive regulation of peptidyl-tyrosine phosphorylation; positive regulation of phagocytosis, engulfment; positive regulation of tumor necrosis factor production; receptor internalization; response to activity; response to drug; response to estradiol stimulus; response to lipid; response to mechanical stimulus; response to nutrient; sensory perception of taste; sequestering of lipid; signal transduction; triacylglycerol metabolic process; triacylglycerol transport