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14.3.3 sigma Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS836352

MBS836352 is a recombinant protein targeting 14.3.3 sigma. Also known as 14.3.3 sigma protein. Host: Human. Purified recombinant Human 14.3.3 sigma protein More details

$665 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
14.3.3 sigma, Recombinant Protein
Full Product Name
14.3.3 sigma protein
Product Gene Name
14.3.3 sigma recombinant protein
Product Synonym Names
HME1 protein; SFN protein; 14.3.3 sigma; Epithelial cell marker protein 1 protein; stratifin protein; 14-3-3 sigma protein; 14/3/3 sigma protein; YWHAS protein; 14-3-3 sigma; 14/3/3 sigma
Sequence
1-248 amino acids: MERASLIQKA KLAEQAERYE DMAAFMKGAV EKGEELSCEE RNLLSVAYKN VVGGQRAAWR VLSSIEQKSN EEGSEEKGPE VREYREKVET ELQGVCDTVL GLLDSHLIKE AGDAESRVFY LKMKGDYYRY LAEVATGDDK KRIIDSARSA YQEAMDISKK EMPPTNPIRL GLALNFSVFH YEIANSPEEA ISLAKTTFDE AMADLHTLSE DSYKDSTLIM QLLRDNLTLW TADNAGEEGG EAPQEPQS
Host
Human
Form/Format
Supplied as a liquid in 20mM Tris-HCl buffer, pH 8.0, containing 50mM NaCl and 10% glycerol.
Purity/Purification
> 95% pure
Concentration
1 mg/ml (lot specific)
Preparation and Storage
Store at 4 degree C for short term storage (1/2 weeks). Aliquot and store at -20 degree C or - 70 degree C for long term storage. Avoid repeated freeze/thaw cycles.
Molecular Weight
27.7 kDa (248aa), confirmed by MALDI-TOF.
OMIM
601290
3D Structure
ModBase 3D Structure for P31947
Protein Type
Recombinant
Expression System
E Coli

Product Categories/Family for 14.3.3 sigma recombinant protein

Cell Cycle & Cell Death
Applications Tested/Suitable for 14.3.3 sigma recombinant protein
SDS-PAGE

SDS-PAGE of 14.3.3 sigma recombinant protein

Figure annotation denotes ug of protein loaded and % gel used.
14.3.3 sigma Recombinant Protein – Cat# MBS836352

Other Notes

Small volumes of 14.3.3 sigma recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for 14.3.3 sigma. It may not necessarily be applicable to this product.

NCBI GI #
5454052
NCBI GeneID
2810
NCBI Accession #
NP_006133.1
UniProt Primary Accession #
P31947
UniProt Secondary Accession #
Q6FH30; Q6FH51; Q96DH0
UniProt Related Accession #
P31947
GenBank Nucleotide #
NM_006142.3
NCBI Official Full Name
14-3-3 protein sigma
NCBI Official Synonym Full Names
stratifin
NCBI Official Symbol
SFN
NCBI Official Synonym Symbols
YWHAS
UniProt Protein Name
14-3-3 protein sigma
UniProt Synonym Protein Names
Epithelial cell marker protein 1; Stratifin
Protein Family
14-3-3 protein
UniProt Gene Name
SFN
UniProt Synonym Gene Names
HME1
UniProt Entry Name
1433S_HUMAN
NCBI Protein Information
14-3-3 protein sigma

UniProt Comments for 14.3.3 sigma

14-3-3 sigma: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. Homodimer. Interacts with KRT17 and SAMSN1. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with GAB2. Interacts with SRPK2. Present mainly in tissues enriched in stratified squamous keratinizing epithelium. Belongs to the 14-3-3 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 1p36.11

Cellular Component: extracellular space; cytoplasmic vesicle membrane; cytoplasm; nucleus; cytosol

Molecular Function: protein domain specific binding; protein kinase C inhibitor activity; protein binding; phosphoprotein binding; protein kinase binding

Biological Process: positive regulation of protein export from nucleus; regulation of epidermal cell division; release of cytochrome c from mitochondria; DNA damage response, signal transduction resulting in induction of apoptosis; apoptosis; keratinization; positive regulation of epidermal cell differentiation; negative regulation of protein kinase activity; negative regulation of caspase activity; regulation of cyclin-dependent protein kinase activity; signal transduction; positive regulation of cell growth
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Research Articles on 14.3.3 sigma

1. SFN affects the water-holding capacity, barrier function and dermal matrix components in photoaging skin. An increase of SFN triggered by UVB irradiation may be one of the causes of alterations observed in photoaging skin.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with 14.3.3 sigma recombinant protein

 Reference Product  PubMed Publications
 TP53 recombinant protein  >17 publications with 14.3.3 sigma and TP53
 MAPK1 recombinant protein  >7 publications with 14.3.3 sigma and MAPK1
 CDK1 recombinant protein  >6 publications with 14.3.3 sigma and CDK1
 BAD recombinant protein  >3 publications with 14.3.3 sigma and BAD
 AKT1 recombinant protein  >2 publications with 14.3.3 sigma and AKT1
 CDC25B recombinant protein  >2 publications with 14.3.3 sigma and CDC25B
 UBC recombinant protein  >1 publications with 14.3.3 sigma and UBC
 TSC2 recombinant protein  >1 publications with 14.3.3 sigma and TSC2

Pathways associated with 14.3.3 sigma recombinant protein

 Products by Pathway  Pathway Diagram
 Activation Of BAD And Translocation To Mitochondria Pathway antibodies  Activation Of BAD And Translocation To Mitochondria Pathway Diagram
 Activation Of BH3-only Proteins Pathway antibodies  Activation Of BH3-only Proteins Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Aldosterone-regulated Sodium Reabsorption Pathway antibodies  Aldosterone-regulated Sodium Reabsorption Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram
 Cell Cycle Checkpoints Pathway antibodies  Cell Cycle Checkpoints Pathway Diagram
 Cell Cycle Pathway antibodies  Cell Cycle Pathway Diagram

Diseases associated with 14.3.3 sigma recombinant protein

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >186 publications with 14.3.3 sigma and Carcinoma
 Adenocarcinoma Antibodies  >89 publications with 14.3.3 sigma and Adenocarcinoma
 Breast Neoplasms Antibodies  >88 publications with 14.3.3 sigma and Breast Neoplasms
 Inflammation Antibodies  >61 publications with 14.3.3 sigma and Inflammation
 Necrosis Antibodies  >52 publications with 14.3.3 sigma and Necrosis
 Prostatic Neoplasms Antibodies  >44 publications with 14.3.3 sigma and Prostatic Neoplasms
 Disease Models, Animal Antibodies  >38 publications with 14.3.3 sigma and Disease Models, Animal
 Neoplasm Metastasis Antibodies  >37 publications with 14.3.3 sigma and Neoplasm Metastasis
 Lung Neoplasms Antibodies  >37 publications with 14.3.3 sigma and Lung Neoplasms
 Carcinoma, Squamous Cell Antibodies  >33 publications with 14.3.3 sigma and Carcinoma, Squamous Cell

Organs/Tissues associated with 14.3.3 sigma recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Skin Antibodies  >126 publications with 14.3.3 sigma and Skin
 Blood Antibodies  >111 publications with 14.3.3 sigma and Blood
 Nerve Antibodies  >89 publications with 14.3.3 sigma and Nerve
 Prostate Antibodies  >64 publications with 14.3.3 sigma and Prostate
 Lung Antibodies  >57 publications with 14.3.3 sigma and Lung
 Liver Antibodies  >54 publications with 14.3.3 sigma and Liver
 Brain Antibodies  >49 publications with 14.3.3 sigma and Brain
 Thyroid Antibodies  >39 publications with 14.3.3 sigma and Thyroid
 Muscle Antibodies  >31 publications with 14.3.3 sigma and Muscle
 Lymph Node Antibodies  >29 publications with 14.3.3 sigma and Lymph Node
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