APOH Recombinant Protein

Name: APOH Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS205332
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS205332

Apolipoprotein H, also known as APOH, binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. This protein may prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on… More details

$230 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

APOH, Recombinant Protein

Full Product Name

APOH, 20-345aa, Human, His tag, E Coli (Denatured)

Product Gene Name

APOH recombinant protein

Product Synonym Names

Beta-2-glycoprotein 1; Apolipoprotein H; B2G1; B2GP1; BG

Sequence

MGSSHHHHHH SSGLVPRGSH MGSGRTCPKP DDLPFSTVVP LKTFYEPGEE ITYSCKPGYV SRGGMRKFIC PLTGLWPINT LKCTPRVCPF AGILENGAVR YTTFEYPNTI SFSCNTGFYL NGADSAKCTE EGKWSPELPV CAPIICPPPS IPTFATLRVY KPSAGNNSLY RDTAVFECLP QHAMFGNDTI TCTTHGNWTK LPECREVKCP FPSRPDNGFV NYPAKPTLYY KDKATFGCHD GYSLDGPEEI ECTKLGNWSA MPSCKASCKV PVKKATVVYQ GERVKIQEKF KNGMLHGDKV SFFCKNKEKK CSYTEDAQCI DGTIEVPKCF KEHSSLAFWK TDASDVKPC

Host

E Coli

Form/Format

Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 2M urea, 10% glycerol

Purity/Purification

> 85% by SDS-PAGE

Concentration

0.5 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

38.6 kDa (349aa)

OMIM

X58100 mRNA

3D Structure

ModBase 3D Structure for P02749

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for APOH recombinant protein

Metabolism

Applications Tested/Suitable for APOH recombinant protein

SDS-PAGE

Application Notes for APOH recombinant protein

This protein is denatured. Denatured protein is most likely not the best option for functional studies. Denatured protein is better suited for Western Blot (WB) or imaging assays. Applications are user determined.

Product References and Citations for APOH recombinant protein

Steinkasserer A., et al. (1993) Hum. Genet. 91:401-402; Schwarzenbacher R., et al. (1999) EMBO J. 18:6228-6239;

Other Notes

Small volumes of APOH recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for APOH purchase

MBS205332 is a recombinant protein targeting APOH. Also known as APOH, 20-345aa, Human, His tag, E Coli (Denatured). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for APOH. It may not necessarily be applicable to this product.

NCBI GI #

153266841

NCBI GeneID

350

NCBI Accession #

NP_000033

UniProt Primary Accession #

P02749

UniProt Secondary Accession #

Q9UCN7; B2R9M3

UniProt Related Accession #

P02749

GenBank Nucleotide #

NM_000042.2

NCBI Official Full Name

beta-2-glycoprotein 1

NCBI Official Synonym Full Names

apolipoprotein H

NCBI Official Symbol

APOH

NCBI Official Synonym Symbols

BG; B2G1; B2GP1

UniProt Protein Name

Beta-2-glycoprotein 1

UniProt Synonym Protein Names

APC inhibitor; Activated protein C-binding protein; Anticardiolipin cofactor; Apolipoprotein H; Apo-H; Beta-2-glycoprotein I; B2GPI; Beta(2)GPI

Protein Family

Beta-2-glycoprotein

UniProt Gene Name

APOH

UniProt Synonym Gene Names

B2G1; Apo-H; B2GPI; Beta(2)GPI

NCBI Protein Information

beta-2-glycoprotein 1

NCBI Summary for APOH

Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections. [provided by RefSeq, Jul 2008]

UniProt Comments for APOH

Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.

Research Articles on APOH

1. we have demonstrated a pathogenic role for aPL containing samples, mediated via aPL-2bGPI interactions, resulting in activation of the pro-apoptotic p38 MAPK pathway.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with APOH recombinant protein

Reference Product	PubMed Publications
FGA recombinant protein	>2 publications with APOH and FGA
ALB recombinant protein	>2 publications with APOH and ALB
ORM1 recombinant protein	>1 publications with APOH and ORM1
PLG recombinant protein	>1 publications with APOH and PLG
FGB recombinant protein	>1 publications with APOH and FGB
FGG recombinant protein	>1 publications with APOH and FGG
AHSG recombinant protein	>1 publications with APOH and AHSG

Pathways associated with APOH recombinant protein

Products by Pathway	Pathway Diagram
Hemostasis Pathway antibodies	Hemostasis Pathway Diagram
Platelet Activation, Signaling And Aggregation Pathway antibodies	Platelet Activation, Signaling And Aggregation Pathway Diagram
Platelet Degranulation Pathway antibodies	Platelet Degranulation Pathway Diagram
Response To Elevated Platelet Cytosolic Ca2+ Pathway antibodies	Response To Elevated Platelet Cytosolic Ca2+ Pathway Diagram

Diseases associated with APOH recombinant protein

Disease Name	Pubmed Publications
Cardiovascular Diseases Antibodies	>25 publications with APOH and Cardiovascular Diseases
Liver Diseases Antibodies	>13 publications with APOH and Liver Diseases
Inflammation Antibodies	>9 publications with APOH and Inflammation
Hemorrhage Antibodies	>5 publications with APOH and Hemorrhage
Diabetes Mellitus Antibodies	>4 publications with APOH and Diabetes Mellitus
Hypertension Antibodies	>4 publications with APOH and Hypertension
Kidney Diseases Antibodies	>3 publications with APOH and Kidney Diseases
Liver Neoplasms Antibodies	>3 publications with APOH and Liver Neoplasms
Carcinoma Antibodies	>3 publications with APOH and Carcinoma
Cognition Disorders Antibodies	>2 publications with APOH and Cognition Disorders

Organs/Tissues associated with APOH recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>67 publications with APOH and Blood
Liver Antibodies	>29 publications with APOH and Liver
Brain Antibodies	>9 publications with APOH and Brain
Muscle Antibodies	>4 publications with APOH and Muscle
Heart Antibodies	>4 publications with APOH and Heart
Kidney Antibodies	>4 publications with APOH and Kidney
Lung Antibodies	>3 publications with APOH and Lung
Connective Tissue Antibodies	>2 publications with APOH and Connective Tissue
Intestine Antibodies	>2 publications with APOH and Intestine
Embryonic Tissue Antibodies	>1 publications with APOH and Embryonic Tissue