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ASNA1 Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS204219

ASNA1, also as known as ARSA and TRC40, belongs to the arsA ATPase family. ASNA1 is the human homolog of the bacterial arsA gene. In E Coli, ArsA ATPase is the catalytic component of a multisubunit oxyanion pump that is responsible for resistance to… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
ASNA1, Recombinant Protein
Full Product Name
ASNA1, 1-348aa, Human, His tag, E Coli
Product Gene Name
ASNA1 recombinant protein
Product Synonym Names
ATPase ASNA1; ARSA-I; ARSA1; ASNA-I; GET3; hASNA-I; TRC40
Sequence
MGSSHHHHHH SSGLVPRGSH MGSMAAGVAG WGVEAEEFED APDVEPLEPT LSNIIEQRSL KWIFVGGKGG VGKTTCSCSL AVQLSKGRES VLIISTDPAH NISDAFDQKF SKVPTKVKGY DNLFAMEIDP SLGVAELPDE FFEEDNMLSM GKKMMQEAMS AFPGIDEAMS YAEVMRLVKG MNFSVVVFDT APTGHTLRLL NFPTIVERGL GRLMQIKNQI SPFISQMCNM LGLGDMNADQ LASKLEETLP VIRSVSEQFK DPEQTTFICV CIAEFLSLYE TERLIQELAK CKIDTHNIIV NQLVFPDPEK PCKMCEARHK IQAKYLDQME DLYEDFHIVK LPLLPHEVRG ADKVNTFSAL LLEPYKPPSA Q
Host
E Coli
Form/Format
Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 10% glycerol
Purity/Purification
> 90% by SDS-PAGE
Concentration
1 mg/ml (determined by Bradford assay) (lot specific)
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
41.2kDa (371aa) confirmed by MALDI-TOF
OMIM
AF047469 mRNA
3D Structure
ModBase 3D Structure for O43681
Antigen Species
Human
Tag Information
His-tag

Product Categories/Family for ASNA1 recombinant protein

Metabolism
Applications Tested/Suitable for ASNA1 recombinant protein
SDS-PAGE

SDS-Page of ASNA1 recombinant protein

ASNA1 Recombinant Protein – Cat# MBS204219

Product References and Citations for ASNA1 recombinant protein

Stefanovic S., et al. (2007) Cell 128:1147-1159; Favaloro V., et al. (2008) J. Cell Sci. 121:1832-1840

Other Notes

Small volumes of ASNA1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ASNA1 purchase

MBS204219 is a recombinant protein targeting ASNA1. Also known as ASNA1, 1-348aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for ASNA1. It may not necessarily be applicable to this product.

NCBI GI #
50428938
NCBI GeneID
439
NCBI Accession #
NP_004308
UniProt Primary Accession #
O43681
UniProt Secondary Accession #
Q53FC6; Q92849; A6NHP8; A8K740
UniProt Related Accession #
O43681
GenBank Nucleotide #
NM_004317.3
NCBI Official Full Name
ATPase ASNA1
NCBI Official Synonym Full Names
arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)
NCBI Official Symbol
ASNA1
NCBI Official Synonym Symbols
GET3; ARSA1; TRC40; ARSA-I; ASNA-I
UniProt Protein Name
ATPase ASNA1
UniProt Synonym Protein Names
Arsenical pump-driving ATPase
Protein Family
ATPase
UniProt Gene Name
ASNA1
NCBI Protein Information
ATPase ASNA1

NCBI Summary for ASNA1

This gene represents the human homolog of the bacterial arsA gene, encoding the arsenite-stimulated ATPase component of the arsenite transporter responsible for resistance to arsenicals. This protein is also a central component of a transmembrane domain (TMD) recognition complex (TRC) that is involved in the post-translational delivery of tail-anchored (TA) proteins from the cytosol to the endoplasmic reticulum (ER). It recognizes and selectively binds the TMD of TA proteins in the cytosol, and delivers them to the ER for insertion. [provided by RefSeq, Oct 2011]
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UniProt Comments for ASNA1

ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting (). May be involved in insulin signaling.
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Research Articles on ASNA1

1. The authors conclude that the TRC40 pathway is critical for hearing and propose that otoferlin is an essential substrate of this pathway in hair cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with ASNA1 recombinant protein

 Reference Product  PubMed Publications
 WRB recombinant protein  >6 publications with ASNA1 and WRB
 SEC61B recombinant protein  >4 publications with ASNA1 and SEC61B
 BAG6 recombinant protein  >2 publications with ASNA1 and BAG6
 SERP1 recombinant protein  >1 publications with ASNA1 and SERP1

Pathways associated with ASNA1 recombinant protein

 Products by Pathway  Pathway Diagram
 IRE1alpha Activates Chaperones Pathway antibodies  IRE1alpha Activates Chaperones Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Unfolded Protein Response (UPR) Pathway antibodies  Unfolded Protein Response (UPR) Pathway Diagram
 XBP1(S) Activates Chaperone Genes Pathway antibodies  XBP1(S) Activates Chaperone Genes Pathway Diagram

Diseases associated with ASNA1 recombinant protein

 Disease Name  Pubmed Publications
 Insulin Resistance Antibodies  >2 publications with ASNA1 and Insulin Resistance
 Fibrosis Antibodies  >1 publications with ASNA1 and Fibrosis
 Brain Diseases Antibodies  >1 publications with ASNA1 and Brain Diseases
 Hyperglycemia Antibodies  >1 publications with ASNA1 and Hyperglycemia
 Abnormalities, Multiple Antibodies  >1 publications with ASNA1 and Abnormalities, Multiple

Organs/Tissues associated with ASNA1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >5 publications with ASNA1 and Liver
 Brain Antibodies  >4 publications with ASNA1 and Brain
 Blood Antibodies  >2 publications with ASNA1 and Blood
 Pancreas Antibodies  >2 publications with ASNA1 and Pancreas
 Spleen Antibodies  >2 publications with ASNA1 and Spleen
 Heart Antibodies  >2 publications with ASNA1 and Heart
 Kidney Antibodies  >1 publications with ASNA1 and Kidney
 Intestine Antibodies  >1 publications with ASNA1 and Intestine
 Eye Antibodies  >1 publications with ASNA1 and Eye
 Testis Antibodies  >1 publications with ASNA1 and Testis
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