B7-H3/CD276 Cynomolgus Recombinant Protein

Protein Construction: Recombinant Cynomolgus CD276 is produced by our mammalian expression system and the target gene encoding Leu29-Glu465 is expressed with a 6His tag at the C-terminus.

Background: CD276, also known as B7-H3, is a member of the B7 superfamily with signature IgV and IgG regions in extracellular domains. It is a type I transmembrane protein and shares 20-27% amino acid identity with other B7 family members. B7-H3 is involved in the activation of T lymphocytes, and regulates murine bone formation. It is also reported that B7-H3 may play an important role in muscle-immune interactions, providing further evidence of the active role of muscle cells in local immunoregulatory processes. B7-H3 is expressed on T-cells, natural killer cells, and antigen presenting cells, as well as some non-immune cells, such as osteoblasts, fibroblasts, fibroblast-like synoviocytes and epithelial cells. High expression of B7-H3 in tumor vasculature also correlates with poor survival in patients, suggesting that it may play a role in tumor cell migration.

Small volumes of B7-H3/CD276 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS2557582 is a recombinant protein targeting B7-H3/CD276. Also known as Recombinant Cynomolgus B7-H3/CD276 Protein (C-His). Host: Human Cells.