• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

BAFF Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS188097

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and… More details

$300 / 0.01 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
BAFF, Recombinant Protein
Full Product Name
Recombinant Human BAFF protein with N-terminal human Fc
Product Gene Name
BAFF recombinant protein
Product Synonym Names
Human BAFF Protein, hFc Tag; TNFSF13B;BAFF;BLYS;CD257;DTL;TALL1;THANK;TNFSF20;ZTNF4;TALL-1
Sequence
hFc(Glu99- Ala330)+BA FF(Ala134- Leu285)
Host
HEK293 cells
Form/Format
Lyophilized from sterile PBS, pH 7.4. Normally 5%-47% trehalose is added as protectants before lyophilization.
Purity/Purification
The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Preparation and Storage
Store at -80 degree C for 12 months (Avoid repeated freezing and thawing)
Shipping: Blue Ice
Molecular Weight
17,578 Da
OMIM
603969
3D Structure
ModBase 3D Structure for Q9Y275
Source
Human
Conjugation
N-Human Fc tag
Reconstitution
Reconstitute with deionized water
Applications Tested/Suitable for BAFF recombinant protein
Western Blot (WB), ELISA (EIA)

ELISA (EIA) of BAFF recombinant protein

Figure 1. Human BAFF Protein, hFc Tag on SDS-PAGE under reducing condition.
Human BAFF Recombinant Protein – Cat# MBS188097

SDS-Page of BAFF recombinant protein

Figure 1. Human BAFF Protein, hFc Tag on SDS-PAGE under reducing condition.
Human BAFF Recombinant Protein, SDS-Page – Cat# MBS188097

Other Notes

Small volumes of BAFF recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BAFF purchase

MBS188097 is a recombinant protein targeting BAFF. Also known as Recombinant Human BAFF protein with N-terminal human Fc. Host: HEK293 cells.

Additional Details

NCBI/Uniprot data below describe general gene information for BAFF. It may not necessarily be applicable to this product.

NCBI GI #
224548983
NCBI GeneID
10673
NCBI Accession #
NP_001139117.1
UniProt Primary Accession #
Q9Y275
UniProt Secondary Accession #
Q6FHD6; Q7Z5J2; E0ADT7
UniProt Related Accession #
Q9Y275
GenBank Nucleotide #
NM_001145645.2
NCBI Official Full Name
tumor necrosis factor ligand superfamily member 13B isoform 2
NCBI Official Synonym Full Names
tumor necrosis factor (ligand) superfamily, member 13b
NCBI Official Symbol
TNFSF13B
NCBI Official Synonym Symbols
DTL; BAFF; BLYS; CD257; TALL1; THANK; ZTNF4; TALL-1; TNFSF20
UniProt Protein Name
Tumor necrosis factor ligand superfamily member 13B
UniProt Synonym Protein Names
B lymphocyte stimulator; BLyS; B-cell-activating factor; BAFF; Dendritic cell-derived TNF-like molecule; TNF- and APOL-related leukocyte expressed ligand 1; TALL-1; CD_antigen: CD257Cleaved into the following 2 chains:Tumor necrosis factor ligand superfamily member 13b, membrane form; Tumor necrosis factor ligand superfamily member 13b, soluble form
Protein Family
Tumor necrosis factor receptor superfamily
UniProt Gene Name
TNFSF13B
UniProt Synonym Gene Names
BAFF; BLYS; TALL1; TNFSF20; ZTNF4; BLyS; TALL-1
UniProt Entry Name
TN13B_HUMAN
NCBI Protein Information
tumor necrosis factor ligand superfamily member 13B; ApoL related ligand TALL-1; B-cell-activating factor; B-lymphocyte stimulator; Delta4 BAFF; TNF and ApoL-related leukocyte expressed ligand 1; TNF homolog that activates apoptosis; delta BAFF; dendritic

UniProt Comments for BAFF

BAFF: Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response. Belongs to the tumor necrosis factor family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; Membrane protein, integral; Cell cycle regulation; Cytokine

Chromosomal Location of Human Ortholog: 13q32-q34

Cellular Component: extracellular space; perinuclear region of cytoplasm; cytoplasm; plasma membrane; integral to membrane

Molecular Function: protein binding; cytokine activity; tumor necrosis factor receptor binding; receptor binding

Biological Process: cell proliferation; B cell costimulation; B cell homeostasis; immunoglobulin secretion; T cell costimulation; positive regulation of cell proliferation; positive regulation of germinal center formation; positive regulation of B cell proliferation; immune response; positive regulation of T cell proliferation; signal transduction
Show more

Research Articles on BAFF

1. Irrespective of HLA Ab status, sBAFF levels progressively increased in all patients in the first posttransplant year, thereafter reaching a plateau.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with BAFF recombinant protein

 Reference Product  PubMed Publications
 TNFRSF13C recombinant protein  >121 publications with BAFF and TNFRSF13C
 TNFRSF17 recombinant protein  >104 publications with BAFF and TNFRSF17
 TNFRSF13B recombinant protein  >78 publications with BAFF and TNFRSF13B
 IL6 recombinant protein  >14 publications with BAFF and IL6
 AICDA recombinant protein  >6 publications with BAFF and AICDA
 IFNG recombinant protein  >2 publications with BAFF and IFNG
 CD40LG recombinant protein  >1 publications with BAFF and CD40LG

Pathways associated with BAFF recombinant protein

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 Intestinal Immune Network For IgA Production Pathway antibodies  Intestinal Immune Network For IgA Production Pathway Diagram
 NF-kappa B Signaling Pathway antibodies  NF-kappa B Signaling Pathway Diagram
 Rheumatoid Arthritis Pathway antibodies  Rheumatoid Arthritis Pathway Diagram
 Rheumatoid Arthritis Pathway antibodies  Rheumatoid Arthritis Pathway Diagram
 Spinal Cord Injury Pathway antibodies  Spinal Cord Injury Pathway Diagram

Diseases associated with BAFF recombinant protein

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >452 publications with BAFF and Necrosis
 Inflammation Antibodies  >77 publications with BAFF and Inflammation
 Nervous System Diseases Antibodies  >54 publications with BAFF and Nervous System Diseases
 Kidney Diseases Antibodies  >31 publications with BAFF and Kidney Diseases
 Skin Diseases Antibodies  >25 publications with BAFF and Skin Diseases
 Liver Diseases Antibodies  >14 publications with BAFF and Liver Diseases
 Bone Marrow Diseases Antibodies  >13 publications with BAFF and Bone Marrow Diseases
 Thrombocytopenia Antibodies  >12 publications with BAFF and Thrombocytopenia
 Hyperplasia Antibodies  >10 publications with BAFF and Hyperplasia
 Leukopenia Antibodies  >8 publications with BAFF and Leukopenia

Organs/Tissues associated with BAFF recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >608 publications with BAFF and Blood
 Bone Marrow Antibodies  >69 publications with BAFF and Bone Marrow
 Lymph Node Antibodies  >46 publications with BAFF and Lymph Node
 Kidney Antibodies  >37 publications with BAFF and Kidney
 Skin Antibodies  >18 publications with BAFF and Skin
 Vascular Antibodies  >14 publications with BAFF and Vascular
 Liver Antibodies  >13 publications with BAFF and Liver
 Brain Antibodies  >13 publications with BAFF and Brain
 Thymus Antibodies  >8 publications with BAFF and Thymus
 Pharynx Antibodies  >8 publications with BAFF and Pharynx
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000