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BAG3 Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203482

BAG3 was reported initially as a protein-refolding cochaperone of the bcl2 binding protein BAG family and as upregulated in response to persistent stress of cellular calcium balance dysregulation. The BAG domains of BAG1, BAG2, and BAG3 interact specifically… More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
BAG3, Recombinant Protein
Full Product Name
BAG3, 1-575aa, Human, His tag, E Coli
Product Gene Name
BAG3 recombinant protein
Product Synonym Names
BAG family molecular chaperone regulator 3; BIS; CAIR-1; BAG family molecular chaperone regulator 3 BAG 3; Bcl 2 binding protein; BCL2 associated athanogene 3; BCL2 binding athanogene 3; Docking protein CAIR 1.
Sequence
MGSSHHHHHH SSGLVPRGSH MSAATHSPMM QVASGNGDRD PLPPGWEIKI DPQTGWPFFV DHNSRTTTWN DPRVPSEGPK ETPSSANGPS REGSRLPPAR EGHPVYPQLR PGYIPIPVLH EGAENRQVHP FHVYPQPGMQ RFRTEAAAAA PQRSQSPLRG MPETTQPDKQ CGQVAAAAAA QPPASHGPER SQSPAASDCS SSSSSASLPS SGRSSLGSHQ LPRGYISIPV IHEQNVTRPA AQPSFHQAQK THYPAQQGEY QTHQPVYHKI QGDDWEPRPL RAASPFRSSV QGASSREGSP ARSSTPLHSP SPIRVHTVVD RPQQPMTHRE TAPVSQPENK PESKPGPVGP ELPPGHIPIQ VIRKEVDSKP VSQKPPPPSE KVEVKVPPAP VPCPPPSPGP SAVPSSPKSV ATEERAAPST APAEATPPKP GEAEAPPKHP GVLKVEAILE KVQGLEQAVD NFEGKKTDKK YLMIEEYLTK ELLALDSVDP EGRADVRQAR RDGVRKVQTI LEKLEQKAID VPGQVQVYEL QPSNLEADQP LQAIMEMGAV AADKGKKNAG NAEDPHTETQ QPEATAAATS NPSSMTDTPG NPAAP
Host
E Coli
Form/Format
Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 1mM EDTA, 0.1mM PMSF, 10% glycerol
Purity/Purification
> 90% by SDS-PAGE
Concentration
0.5 mg/ml (determined by Bradford assay) (lot specific)
Preparation and Storage
Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.
Molecular Weight
63.7 kDa (595aa)
OMIM
AF095193 mRNA
3D Structure
ModBase 3D Structure for O95817
Antigen Species
Human
Tag Information
His-tag

Product Categories/Family for BAG3 recombinant protein

Heat Shock Proteins
Applications Tested/Suitable for BAG3 recombinant protein
SDS-PAGE

SDS-Page of BAG3 recombinant protein

BAG3 Recombinant Protein – Cat# MBS203482

Product References and Citations for BAG3 recombinant protein

Virador VM., et al. (2009) PLos One. 4 (4):e5136. ; Kyratsous CA., et al. (2008) Proc Natl Acad Sci u S A. 105 (52):20912-7.;

Other Notes

Small volumes of BAG3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BAG3 purchase

MBS203482 is a recombinant protein targeting BAG3. Also known as BAG3, 1-575aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for BAG3. It may not necessarily be applicable to this product.

NCBI GI #
14043024
NCBI GeneID
9531
NCBI Accession #
NP_004272
UniProt Primary Accession #
O95817
UniProt Secondary Accession #
Q3B763; Q9NT20; Q9P120; A8K5L8
UniProt Related Accession #
O95817
GenBank Nucleotide #
NM_004281.3
NCBI Official Full Name
BAG family molecular chaperone regulator 3
NCBI Official Synonym Full Names
BCL2 associated athanogene 3
NCBI Official Symbol
BAG3
NCBI Official Synonym Symbols
BIS; MFM6; BAG-3; CAIR-1
UniProt Protein Name
BAG family molecular chaperone regulator 3
UniProt Synonym Protein Names
Bcl-2-associated athanogene 3; Bcl-2-binding protein Bis; Docking protein CAIR-1
Protein Family
BAG family molecular chaperone regulator
UniProt Gene Name
BAG3
UniProt Synonym Gene Names
BIS; BAG-3
NCBI Protein Information
BAG family molecular chaperone regulator 3

NCBI Summary for BAG3

BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The protein encoded by this gene contains a WW domain in the N-terminal region and a BAG domain in the C-terminal region. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]
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UniProt Comments for BAG3

Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:9873016, PubMed:27474739). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920).
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Research Articles on BAG3

1. Our findings suggest that high levels of BIS expression might confer stem-cell-like properties on cancer cells through STAT3 stabilization

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with BAG3 recombinant protein

 Reference Product  PubMed Publications
 HSPA8 recombinant protein  >8 publications with BAG3 and HSPA8
 HSPA1A recombinant protein  >7 publications with BAG3 and HSPA1A
 HSPA2 recombinant protein  >3 publications with BAG3 and HSPA2
 HSPA14 recombinant protein  >1 publications with BAG3 and HSPA14
 HSPA6 recombinant protein  >1 publications with BAG3 and HSPA6

Pathways associated with BAG3 recombinant protein

 Products by Pathway  Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 Cellular Response To Heat Stress Pathway antibodies  Cellular Response To Heat Stress Pathway Diagram
 Cellular Responses To Stress Pathway antibodies  Cellular Responses To Stress Pathway Diagram
 Regulation Of HSF1-mediated Heat Shock Response Pathway antibodies  Regulation Of HSF1-mediated Heat Shock Response Pathway Diagram

Diseases associated with BAG3 recombinant protein

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >63 publications with BAG3 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >44 publications with BAG3 and Cardiovascular Diseases
 Heart Diseases Antibodies  >40 publications with BAG3 and Heart Diseases
 Myofibrillar Myopathy Antibodies  >32 publications with BAG3 and Myofibrillar Myopathy
 Brain Diseases Antibodies  >20 publications with BAG3 and Brain Diseases
 Disease Models, Animal Antibodies  >19 publications with BAG3 and Disease Models, Animal
 Necrosis Antibodies  >14 publications with BAG3 and Necrosis
 Neoplasms, Experimental Antibodies  >11 publications with BAG3 and Neoplasms, Experimental
 Ovarian Neoplasms Antibodies  >9 publications with BAG3 and Ovarian Neoplasms
 Liver Diseases Antibodies  >9 publications with BAG3 and Liver Diseases

Organs/Tissues associated with BAG3 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >85 publications with BAG3 and Muscle
 Heart Antibodies  >50 publications with BAG3 and Heart
 Brain Antibodies  >46 publications with BAG3 and Brain
 Nerve Antibodies  >23 publications with BAG3 and Nerve
 Blood Antibodies  >18 publications with BAG3 and Blood
 Liver Antibodies  >15 publications with BAG3 and Liver
 Kidney Antibodies  >11 publications with BAG3 and Kidney
 Lung Antibodies  >11 publications with BAG3 and Lung
 Prostate Antibodies  >7 publications with BAG3 and Prostate
 Spinal Cord Antibodies  >7 publications with BAG3 and Spinal Cord
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