BIN1 Recombinant Protein

Name: BIN1 Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS203671
Price: 230 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203671

BIN1, also known as SH3P9, is a nucleocytoplasmic adaptor protein, one of which was initially identified as MYC-interacting protein with features of a tumor suppressor. This protein interacts with and inhibits the oncogenic activity of the myc oncoprotein… More details

$230 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

BIN1, Recombinant Protein

Full Product Name

BIN1, 1-439aa, Human, His tag, E Coli

Product Gene Name

BIN1 recombinant protein

Product Synonym Names

Myc box-dependent-interacting protein 1; AMPH2; AMPHL; MGC10367; SH3P9; Amphiphysin II; Myc box-dependent-interacting protein 1

Sequence

MGSSHHHHHH SSGLVPRGSH MAEMGSKGVT AGKIASNVQK KLTRAQEKVL QKLGKADETK DEQFEQCVQN FNKQLTEGTR LQKDLRTYLA SVKAMHEASK KLNECLQEVY EPDWPGRDEA NKIAENNDLL WMDYHQKLVD QALLTMDTYL GQFPDIKSRI AKRGRKLVDY DSARHHYESL QTAKKKDEAK IAKAEEELIK AQKVFEEMNV DLQEELPSLW NSRVGFYVNT FQSIAGLEEN FHKEMSKLNQ NLNDVLVGLE KQHGSNTFTV KAQPSDNAPA KGNKSPSPPD GSPAATPEIR VNHEPEPAGG ATPGATLPKS PSQPAEASEV AGGTQPAAGA QEPGETAASE AASSSLPAVV VETFPATVNG TVEGGSGAGR LDLPPGFMFK VQAQHDYTAT DTDELQLRAG DVVLVIPFQN PEEQDEGWLM GVKESDWNQH KELEKCRGVF PENFTERVP

Host

E Coli

Form/Format

Liquid. In 20mM Tris buffer (pH 8.0) containing 10% glycerol, 1mM DTT

Purity/Purification

> 90% by SDS-PAGE

Concentration

1 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

50.4 kDa (459aa) confirmed by MALDI-TOF

OMIM

AF004015 mRNA

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for BIN1 recombinant protein

Cancer

Applications Tested/Suitable for BIN1 recombinant protein

SDS-PAGE

Product References and Citations for BIN1 recombinant protein

Sakamuro D., et al. (1996) Nat Genet. 14 (1):69-77. ; Nanda SK., et al. (2006) Gastroenterology. 130 (3):794-809.;

Other Notes

Small volumes of BIN1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BIN1 purchase

MBS203671 is a recombinant protein targeting BIN1. Also known as BIN1, 1-439aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for BIN1. It may not necessarily be applicable to this product.

NCBI GI #

13278633

NCBI GeneID

274

NCBI Accession #

AAH04101

UniProt Secondary Accession #

O00297; O00545; O43867; O60552; O60553; O60554; O60555; O75514; O75515; O75516; O75517

UniProt Related Accession #

O00499

NCBI Official Full Name

Bridging integrator 1

NCBI Official Synonym Full Names

bridging integrator 1

NCBI Official Symbol

BIN1

NCBI Official Synonym Symbols

CNM2; AMPH2; AMPHL; SH3P9

UniProt Protein Name

Myc box-dependent-interacting protein 1

UniProt Synonym Protein Names

Amphiphysin II; Amphiphysin-like protein; Box-dependent myc-interacting protein 1; Bridging integrator 1

Protein Family

Myc box-dependent-interacting protein

UniProt Gene Name

BIN1

UniProt Synonym Gene Names

AMPHL

NCBI Protein Information

myc box-dependent-interacting protein 1

NCBI Summary for BIN1

This gene encodes several isoforms of a nucleocytoplasmic adaptor protein, one of which was initially identified as a MYC-interacting protein with features of a tumor suppressor. Isoforms that are expressed in the central nervous system may be involved in synaptic vesicle endocytosis and may interact with dynamin, synaptojanin, endophilin, and clathrin. Isoforms that are expressed in muscle and ubiquitously expressed isoforms localize to the cytoplasm and nucleus and activate a caspase-independent apoptotic process. Studies in mouse suggest that this gene plays an important role in cardiac muscle development. Alternate splicing of the gene results in several transcript variants encoding different isoforms. Aberrant splice variants expressed in tumor cell lines have also been described. [provided by RefSeq, Mar 2016]

UniProt Comments for BIN1

May be involved in regulation of synaptic vesicle endocytosis. May act as a tumor suppressor and inhibits malignant cell transformation.

Research Articles on BIN1

1. bridging integrator 1 Gene rs7561528 polymorphism contributes to Alzheimer's disease susceptibility in East Asian and Caucasian populations

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with BIN1 recombinant protein

Reference Product	PubMed Publications
PICALM recombinant protein	>75 publications with BIN1 and PICALM
DNM2 recombinant protein	>24 publications with BIN1 and DNM2
AMPH recombinant protein	>4 publications with BIN1 and AMPH
BIN2 recombinant protein	>4 publications with BIN1 and BIN2
SYNJ1 recombinant protein	>1 publications with BIN1 and SYNJ1
SH3GL2 recombinant protein	>1 publications with BIN1 and SH3GL2
DNM1 recombinant protein	>1 publications with BIN1 and DNM1
WASL recombinant protein	>1 publications with BIN1 and WASL

Pathways associated with BIN1 recombinant protein

Products by Pathway	Pathway Diagram
Arf6 Trafficking Events Pathway antibodies	Arf6 Trafficking Events Pathway Diagram
Clathrin-mediated Endocytosis Pathway antibodies	Clathrin-mediated Endocytosis Pathway Diagram
Endocytosis Pathway antibodies	Endocytosis Pathway Diagram
Endocytosis Pathway antibodies	Endocytosis Pathway Diagram
Fc Gamma R-mediated Phagocytosis Pathway antibodies	Fc Gamma R-mediated Phagocytosis Pathway Diagram
Fc Gamma R-mediated Phagocytosis Pathway antibodies	Fc Gamma R-mediated Phagocytosis Pathway Diagram
Membrane Trafficking Pathway antibodies	Membrane Trafficking Pathway Diagram
Vesicle-mediated Transport Pathway antibodies	Vesicle-mediated Transport Pathway Diagram

Diseases associated with BIN1 recombinant protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>151 publications with BIN1 and Nervous System Diseases
Brain Diseases Antibodies	>113 publications with BIN1 and Brain Diseases
Alzheimer Disease Antibodies	>113 publications with BIN1 and Alzheimer Disease
Myopathies, Structural, Congenital Antibodies	>30 publications with BIN1 and Myopathies, Structural, Congenital
Cell Transformation, Neoplastic Antibodies	>18 publications with BIN1 and Cell Transformation, Neoplastic
Heart Diseases Antibodies	>17 publications with BIN1 and Heart Diseases
Breast Neoplasms Antibodies	>13 publications with BIN1 and Breast Neoplasms
Disease Models, Animal Antibodies	>13 publications with BIN1 and Disease Models, Animal
Cognition Disorders Antibodies	>10 publications with BIN1 and Cognition Disorders
Memory Disorders Antibodies	>8 publications with BIN1 and Memory Disorders

Organs/Tissues associated with BIN1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>77 publications with BIN1 and Muscle
Nerve Antibodies	>74 publications with BIN1 and Nerve
Brain Antibodies	>68 publications with BIN1 and Brain
Heart Antibodies	>30 publications with BIN1 and Heart
Blood Antibodies	>21 publications with BIN1 and Blood
Prostate Antibodies	>9 publications with BIN1 and Prostate
Liver Antibodies	>7 publications with BIN1 and Liver
Bone Antibodies	>7 publications with BIN1 and Bone
Embryonic Tissue Antibodies	>7 publications with BIN1 and Embryonic Tissue
Lung Antibodies	>5 publications with BIN1 and Lung