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BLK Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS516587

Recombinant full-length human BLK was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The gene accession number is BC007371.BLK, also known as B lymphoid kinase, is a 55 kd tyrosine kinases with a SH3, SH2 and catalytic domains that… More details

$445 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
BLK, Recombinant Protein
Full Product Name
BLK, Active
Product Gene Name
BLK recombinant protein
Product Synonym Names
MGC10442
Host
Sf9 insect cells
Form/Format
Recombinant protein stored in 50mM Tris-HCl, pH7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
Preparation and Storage
Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
Molecular Weight
57,706 Da
Tag
GST
Species
Human
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.

Product Categories/Family for BLK recombinant protein

Protein Kinases; Apoptosis/Autophagy; Cancer; Cytoplasmic Tyrosine Kinases; Inflammation
Applications Tested/Suitable for BLK recombinant protein
Kinase Assay, Western Blot (WB)

Activity of BLK recombinant protein

Specific Activity: Sample Kinase Activity Plot. For specific information on a given lot, see related technical data sheet.
BLK Recombinant Protein – Cat# MBS516587

SDS-Page of BLK recombinant protein

Purity: Sample Purity Data. For specific information on a given lot, see related technical data sheet.
BLK Recombinant Protein, SDS-Page – Cat# MBS516587

Product References and Citations for BLK recombinant protein

1. Dymecki, SM. et al: Specific expression of a tyrosine kinase gene, blk, in B lymphoid cells. Science. 1990 Jan 19;247(4940):332-6.
2. Burkhardt, AL. et al: Anti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases. Proc Natl Acad Sci U S A. 1991 Aug 15;88(16):7410-4.

Other Notes

Small volumes of BLK recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for BLK purchase

MBS516587 is a recombinant protein targeting BLK. Also known as BLK, Active. Host: Sf9 insect cells.

Additional Details

NCBI/Uniprot data below describe general gene information for BLK. It may not necessarily be applicable to this product.

NCBI GI #
33988212
NCBI GeneID
640
NCBI Accession #
BC007371
UniProt Secondary Accession #
Q16291; Q96IN1
UniProt Related Accession #
P51451
NCBI Official Full Name
Homo sapiens B lymphoid tyrosine kinase, mRNA
NCBI Official Synonym Full Names
BLK proto-oncogene, Src family tyrosine kinase
NCBI Official Symbol
BLK
NCBI Official Synonym Symbols
MODY11
Protein Family
Tyrosine-protein kinase
NCBI Protein Information
tyrosine-protein kinase Blk

NCBI Summary for BLK

This gene encodes a nonreceptor tyrosine-kinase of the src family of proto-oncogenes that are typically involved in cell proliferation and differentiation. The protein has a role in B-cell receptor signaling and B-cell development. The protein also stimulates insulin synthesis and secretion in response to glucose and enhances the expression of several pancreatic beta-cell transcription factors. [provided by RefSeq, Aug 2010]
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Research Articles on BLK

1. Report a novel BLK gene variant in common variable immunodeficiency-patients that causes suppressed B-cell proliferation and reduced ability of B-cells to elicit antigen-specific CD4(+) T-cell responses.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with BLK recombinant protein

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Alpha-synuclein Signaling Pathway antibodies  Alpha-synuclein Signaling Pathway Diagram
 Antigen Activates B Cell Receptor Leading To Generation Of Second Messengers Pathway antibodies  Antigen Activates B Cell Receptor Leading To Generation Of Second Messengers Pathway Diagram
 Apoptosis Modulation And Signaling Pathway antibodies  Apoptosis Modulation And Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 CXCR4-mediated Signaling Events Pathway antibodies  CXCR4-mediated Signaling Events Pathway Diagram
 Class I PI3K Signaling Events Pathway antibodies  Class I PI3K Signaling Events Pathway Diagram
 EPHA Forward Signaling Pathway antibodies  EPHA Forward Signaling Pathway Diagram
 Ephrin B Reverse Signaling Pathway antibodies  Ephrin B Reverse Signaling Pathway Diagram
 Focal Adhesion Pathway antibodies  Focal Adhesion Pathway Diagram

Diseases associated with BLK recombinant protein

 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >65 publications with BLK and Immune System Diseases
 Neoplasms Antibodies  >56 publications with BLK and Neoplasms
 Lupus Erythematosus, Systemic Antibodies  >38 publications with BLK and Lupus Erythematosus, Systemic
 Nervous System Diseases Antibodies  >19 publications with BLK and Nervous System Diseases
 Arthritis, Rheumatoid Antibodies  >17 publications with BLK and Arthritis, Rheumatoid
 Cardiovascular Diseases Antibodies  >15 publications with BLK and Cardiovascular Diseases
 Brain Diseases Antibodies  >14 publications with BLK and Brain Diseases
 Necrosis Antibodies  >13 publications with BLK and Necrosis
 Inflammation Antibodies  >12 publications with BLK and Inflammation
 Drug Toxicity Antibodies  >10 publications with BLK and Drug Toxicity

Organs/Tissues associated with BLK recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >127 publications with BLK and Blood
 Spleen Antibodies  >15 publications with BLK and Spleen
 Lung Antibodies  >12 publications with BLK and Lung
 Bone Marrow Antibodies  >10 publications with BLK and Bone Marrow
 Lymph Node Antibodies  >6 publications with BLK and Lymph Node
 Lymph Antibodies  >6 publications with BLK and Lymph
 Thymus Antibodies  >5 publications with BLK and Thymus
 Intestine Antibodies  >3 publications with BLK and Intestine
 Connective Tissue Antibodies  >3 publications with BLK and Connective Tissue
 Mammary Gland Antibodies  >2 publications with BLK and Mammary Gland
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