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BMPR1A Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS7621431

MBS7621431 is a recombinant protein targeting BMPR1A. Also known as Recombinant Mouse BMPR1A. Host: Mammalian Cells. More details

$155 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
BMPR1A, Recombinant Protein
Full Product Name
Recombinant Mouse BMPR1A
Product Gene Name
BMPR1A recombinant protein
Product Synonym Names
ALK-3; Bone morphogenetic protein receptor type-1A; BMP type-1A receptor; BMPR-1A; Activin receptor-like kinase 3; BMP-2/BMP-4 receptor; Serine/threonine-protein kinase receptor R5; SKR5; CD292; Acvrlk3
Sequence
Gln24-Arg1 52
Host
Mammalian Cells
Form/Format
Lyophilized from a 0.2um filtered solution of 20mM PB, 150mM NaCl, pH7.4
Purity/Purification
Greater than 95% as determined by SDS-PAGE.
Preparation and Storage
The lyophilized protein is stable at -20 degree C for up to 1 year. After reconstitution, the protein solution is stable at -20 to -80 degree C for 3 months or 1 week at 2 to 8 degree C under sterile conditions. For extended storage, it is recommended to further dilute in working aliquots, avoid repeated freeze/thaw cycle.
Molecular Weight
60,063 Da
3D Structure
ModBase 3D Structure for P36895
Species
Mouse
Endotoxin
< 1 EU/ug as determined by LAL test.
Tag
C-terminal His-hFc Tag
Reconstitution
Centrifuge the vial at 10000rpm for 30s before opening, reconstitute in sterile distilled water to a concentration of 0.1-1mg/ml by gently pipetting 2-3 times, don't vortex.

Product Categories/Family for BMPR1A recombinant protein

cytokines
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for BMPR1A recombinant protein
Western Blot (WB), ELISA (EIA)

Other Notes

Small volumes of BMPR1A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for BMPR1A. It may not necessarily be applicable to this product.

NCBI GI #
547779
NCBI GeneID
12166
NCBI Accession #
P36895.1
UniProt Primary Accession #
P36895
UniProt Related Accession #
P36895
NCBI Official Full Name
Bone morphogenetic protein receptor type-1A
NCBI Official Synonym Full Names
bone morphogenetic protein receptor, type 1A
NCBI Official Symbol
Bmpr1a
NCBI Official Synonym Symbols
ALK3; Bmpr; BMPR-IA; AU045487; 1110037I22Rik
UniProt Protein Name
Bone morphogenetic protein receptor type-1A
UniProt Synonym Protein Names
Activin receptor-like kinase 3; ALK-3; BMP-2/BMP-4 receptor; Serine/threonine-protein kinase receptor R5; SKR5; CD_antigen: CD292
Protein Family
Bone morphogenetic protein receptor
UniProt Gene Name
Bmpr1a
UniProt Synonym Gene Names
Acvrlk3; Bmpr; BMP type-1A receptor; BMPR-1A; ALK-3; SKR5
UniProt Entry Name
BMR1A_MOUSE
NCBI Protein Information
bone morphogenetic protein receptor type-1A; SKR5; ALK-3; BMPR-1A; BMP type-1A receptor; BMP-2/BMP-4 receptor; activin receptor-like kinase 3; serine/threonine-protein kinase receptor R5

UniProt Comments for BMPR1A

BMPR1A: a serine/threonine-protein kinase receptor for Bone morphogenetic protein-2 and -4 (BMP-2 and BMP-4). Defects in BMPR1A are a cause of juvenile polyposis syndrome (JPS) and Cowden disease (CD), a cancer syndrome characterized by multiple hamartomas and by a high risk for breast, thyroid and endometriel cancers.

Protein type: Membrane protein, integral; Protein kinase, Ser/Thr (receptor); EC 2.7.11.30; Protein kinase, TKL; Kinase, protein; TKL group; STKR family; Type1 subfamily

Cellular Component: cell soma; membrane; dendrite; plasma membrane; integral to membrane; caveola

Molecular Function: transferase activity; protein serine/threonine kinase activity; protein homodimerization activity; metal ion binding; transferase activity, transferring phosphorus-containing groups; nucleotide binding; kinase activity; SMAD binding; transmembrane receptor protein serine/threonine kinase activity; ATP binding; receptor signaling protein serine/threonine kinase activity; protein kinase activity

Biological Process: neural plate mediolateral pattern formation; transcription from RNA polymerase II promoter; paraxial mesoderm development; heart morphogenesis; hindlimb morphogenesis; developmental growth; neural crest cell development; positive regulation of transcription, DNA-dependent; heart development; mesendoderm development; paraxial mesoderm structural organization; dorsal/ventral axis specification; palate development; protein amino acid phosphorylation; negative regulation of neurogenesis; BMP signaling pathway; anterior/posterior pattern formation; transmembrane receptor protein serine/threonine kinase signaling pathway; positive regulation of mesenchymal cell proliferation; ectoderm development; embryonic morphogenesis; cell differentiation; Mullerian duct regression; nervous system development; regulation of endothelial cell proliferation; somitogenesis; in utero embryonic development; lateral mesoderm development; stem cell maintenance; positive regulation of bone mineralization; pattern specification process; regulation of endothelial cell differentiation; odontogenesis of dentine-containing teeth; positive regulation of osteoblast differentiation; mesoderm formation; dorsal/ventral pattern formation; pituitary gland development; cartilage development; embryonic organ development; immune response; embryonic digit morphogenesis; phosphorylation; regulation of lateral mesodermal cell fate specification; positive regulation of epithelial cell proliferation; lung development; endoderm development
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Research Articles on BMPR1A

1. results provide evidence that HFE induces hepcidin expression via the BMP pathway: HFE interacts with ALK3 to stabilize ALK3 protein and increase ALK3 expression at the cell surface.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with BMPR1A recombinant protein

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 ESC Pluripotency Pathways antibodies  ESC Pluripotency Pathways Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram
 Heart Development Pathway antibodies  Heart Development Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 Hippo Signaling Pathway antibodies  Hippo Signaling Pathway Diagram
 PodNet: Protein-protein Interactions In The Podocyte Pathway antibodies  PodNet: Protein-protein Interactions In The Podocyte Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By BMP Pathway antibodies  Signaling By BMP Pathway Diagram

Diseases associated with BMPR1A recombinant protein

 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >59 publications with BMPR1A and Congenital Abnormalities
 Juvenile polyposis syndrome Antibodies  >44 publications with BMPR1A and Juvenile polyposis syndrome
 Female Urogenital Diseases Antibodies  >18 publications with BMPR1A and Female Urogenital Diseases
 Inflammation Antibodies  >17 publications with BMPR1A and Inflammation
 Hyperplasia Antibodies  >13 publications with BMPR1A and Hyperplasia
 Craniofacial Abnormalities Antibodies  >12 publications with BMPR1A and Craniofacial Abnormalities
 Hamartoma Syndrome, Multiple Antibodies  >11 publications with BMPR1A and Hamartoma Syndrome, Multiple
 Abnormalities, Multiple Antibodies  >11 publications with BMPR1A and Abnormalities, Multiple
 Necrosis Antibodies  >8 publications with BMPR1A and Necrosis
 Neoplasm Metastasis Antibodies  >8 publications with BMPR1A and Neoplasm Metastasis

Organs/Tissues associated with BMPR1A recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >115 publications with BMPR1A and Embryonic Tissue
 Heart Antibodies  >54 publications with BMPR1A and Heart
 Brain Antibodies  >52 publications with BMPR1A and Brain
 Bone Marrow Antibodies  >32 publications with BMPR1A and Bone Marrow
 Skin Antibodies  >28 publications with BMPR1A and Skin
 Lung Antibodies  >27 publications with BMPR1A and Lung
 Liver Antibodies  >25 publications with BMPR1A and Liver
 Intestine Antibodies  >24 publications with BMPR1A and Intestine
 Kidney Antibodies  >22 publications with BMPR1A and Kidney
 Eye Antibodies  >20 publications with BMPR1A and Eye
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