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Bone Morphogenetic Protein 2 (BMP2) Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Special Promotion Catalog #: MBS2012162
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MBS2012162 is a recombinant protein targeting BMP2. Also known as Recombinant Bone Morphogenetic Protein 2 (BMP2). Host: E Coli. More details

$225 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Bone Morphogenetic Protein 2 (BMP2), Recombinant Protein
Full Product Name
Recombinant Bone Morphogenetic Protein 2 (BMP2)
Product Gene Name
BMP2 recombinant protein
Sequence
The target protein is fused with a N-terminal His-tag, its sequence is listed below.
MGHHHHHHSG S-QAKHKQRK RL KSSCKRHPLY VDFSDVGWND WIVAPPGYHA FYCHGECPFP LADHLNSTNH AIVQTLVNSV NSKIPKACCV PTELSAISML YLDENEKVVL KNYQDMVVEG CGCR
Host
E Coli
Form/Format
Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl.
Purity/Purification
> 95%
Preparation and Storage
Avoid repeated freeze/thaw cycles. Store at 2-8 degree C for one month. Aliquot and store at -80 degree C for 12 months.
Stability Test: The thermal stability is described by the loss rate of the targetprotein. The loss rate was determined by accelerated thermal degradation test,that is, incubate the protein at 37 degree C for 48h, and no obvious degradation andprecipitation were observed. (Referring from China Biological Products Standard,which was calculated by the Arrhenius equation.) The loss of this protein is lessthan 5% within the expiration date under appropriate storage condition.
Matching Pairs
Unconjugated Antibody: BMP2 (MBS2004087)
Immunogen: BMP2 (MBS2012162)
Matching Pairs
Biotin Conjugated Antibody: BMP2 (MBS2004852)
Immunogen: BMP2 (MBS2012162)
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Molecular Weight
14.1kDa
Chromosome Location
Chromosome: 2; NC_000068.7 (133552159..133562896). Location: 2 F2; 2 65.21 cM
3D Structure
ModBase 3D Structure for P21274
Supply Chain Verification
Manufactured in a lab with traceable raw materials. Bulk orders can typically be prepared to the customer’s specifications, please inquire.
Organism
Mus musculus (Mouse)
Expression System
Prokaryotic expression
Residues
Gln281~Arg394 (Accession # P21274) with a N-terminal His-tag
Endotoxin Level
<1.0EU per 1ug (determined by the LAL method)
Reconstitution
Reconstitute in sterile PBS, pH7.2-pH7.4.
ISO Certification
Manufactured in an ISO 9001:2015 and ISO 13485:2016 Certified Laboratory.
Applications Tested/Suitable for BMP2 recombinant protein
SDS-PAGE, Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP)

Sequence Information of BMP2 recombinant protein

BMP2 Recombinant Protein – Cat# MBS2012162

SDS-Page of BMP2 recombinant protein

BMP2 Recombinant Protein, SDS-Page – Cat# MBS2012162

Other Notes

Small volumes of BMP2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for BMP2. It may not necessarily be applicable to this product.

NCBI GI #
71896669
NCBI GeneID
12156
NCBI Accession #
NP_031579.2
UniProt Primary Accession #
P21274
UniProt Secondary Accession #
Q497W8
UniProt Related Accession #
P21274
GenBank Nucleotide #
NM_007553.3
NCBI Official Full Name
bone morphogenetic protein 2 preproprotein
NCBI Official Synonym Full Names
bone morphogenetic protein 2
NCBI Official Symbol
Bmp2
NCBI Official Synonym Symbols
Bmp2a; AI467020
UniProt Protein Name
Bone morphogenetic protein 2
UniProt Synonym Protein Names
Bone morphogenetic protein 2A
Protein Family
Bone morphogenetic protein
UniProt Gene Name
Bmp2
UniProt Synonym Gene Names
Bmp-2; BMP-2; BMP-2A
UniProt Entry Name
BMP2_MOUSE
NCBI Protein Information
bone morphogenetic protein 2; bone morphogenetic protein 2A

NCBI Summary for BMP2

This gene encodes a member of a family of secreted factors that participate in developmental signal transduction to stimulate SMAD transcriptional activators. The encoded protein is able to induce cartilage and bone formation. The propeptide is further cleaved into an active chain. [provided by RefSeq, Mar 2013]
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UniProt Comments for BMP2

BMP2: Induces cartilage and bone formation. Belongs to the TGF-beta family.

Protein type: Secreted, signal peptide; Secreted; Motility/polarity/chemotaxis

Cellular Component: extracellular space; protein complex; cell surface; cytoplasm; extracellular region

Molecular Function: protein domain specific binding; protein binding; protein homodimerization activity; growth factor activity; protein heterodimerization activity; phosphatase activator activity; cytokine activity; SMAD binding; transforming growth factor beta receptor binding; receptor binding; retinol dehydrogenase activity

Biological Process: activation of MAPK activity; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; heart development; multicellular organismal development; adrenocorticotropin hormone secreting cell differentiation; telencephalon regionalization; protein amino acid phosphorylation; cardiac muscle cell differentiation; regulation of apoptosis; BMP signaling pathway; transforming growth factor beta receptor signaling pathway; chondrocyte differentiation; inner ear development; regulation of odontogenesis of dentine-containing teeth; positive regulation of astrocyte differentiation; pericardium development; positive regulation of neurogenesis; cell fate commitment; organ morphogenesis; mesenchymal cell differentiation; regulation of MAPKKK cascade; positive regulation of osteoblast proliferation; positive regulation of fat cell differentiation; positive regulation of endothelial cell proliferation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of cell differentiation; negative regulation of calcium-independent cell-cell adhesion; positive regulation of odontogenesis; proteoglycan metabolic process; embryonic heart tube anterior/posterior pattern formation; negative regulation of insulin-like growth factor receptor signaling pathway; thyroid stimulating hormone secreting cell differentiation; negative regulation of transcription from RNA polymerase II promoter; bone mineralization; negative regulation of cell cycle; negative regulation of cell proliferation; positive regulation of MAPKKK cascade; regulation of transcription, DNA-dependent; cardiac muscle morphogensis; negative regulation of aldosterone biosynthetic process; cell differentiation; cardiac cell differentiation; positive regulation of Wnt receptor signaling pathway; Notch signaling pathway; ossification; protein destabilization; in utero embryonic development; positive regulation of bone mineralization; positive regulation of ossification; odontogenesis of dentine-containing teeth; osteoblast differentiation; positive regulation of osteoblast differentiation; telencephalon development; embryonic development; ureteric bud branching; cartilage development; response to hypoxia; epithelial to mesenchymal transition; positive regulation of protein amino acid phosphorylation; positive regulation of neuron differentiation; positive regulation of cell migration; growth
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Research Articles on BMP2

1. These data showed that traumatic bone injury caused a systemic induction of BMP2 expression and that this increase is correlated with the mobilization of CD73 positive cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with BMP2 recombinant protein

 Products by Pathway  Pathway Diagram
 Adipogenesis Pathway antibodies  Adipogenesis Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Basal Cell Carcinoma Pathway antibodies  Basal Cell Carcinoma Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Elastic Fibre Formation Pathway antibodies  Elastic Fibre Formation Pathway Diagram
 Extracellular Matrix Organization Pathway antibodies  Extracellular Matrix Organization Pathway Diagram
 Heart Development Pathway antibodies  Heart Development Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram
 Hedgehog Signaling Pathway antibodies  Hedgehog Signaling Pathway Diagram

Diseases associated with BMP2 recombinant protein

 Disease Name  Pubmed Publications
 Bone Diseases Antibodies  >525 publications with BMP2 and Bone Diseases
 Neoplasms Antibodies  >269 publications with BMP2 and Neoplasms
 Necrosis Antibodies  >100 publications with BMP2 and Necrosis
 Inflammation Antibodies  >81 publications with BMP2 and Inflammation
 Pain Antibodies  >44 publications with BMP2 and Pain
 Hypertrophy Antibodies  >40 publications with BMP2 and Hypertrophy
 Hypertension Antibodies  >39 publications with BMP2 and Hypertension
 Fibrosis Antibodies  >30 publications with BMP2 and Fibrosis
 Breast Neoplasms Antibodies  >30 publications with BMP2 and Breast Neoplasms
 Kidney Diseases Antibodies  >25 publications with BMP2 and Kidney Diseases

Organs/Tissues associated with BMP2 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Embryonic Tissue Antibodies  >429 publications with BMP2 and Embryonic Tissue
 Brain Antibodies  >149 publications with BMP2 and Brain
 Kidney Antibodies  >85 publications with BMP2 and Kidney
 Skin Antibodies  >83 publications with BMP2 and Skin
 Liver Antibodies  >65 publications with BMP2 and Liver
 Eye Antibodies  >58 publications with BMP2 and Eye
 Uterus Antibodies  >25 publications with BMP2 and Uterus
 Prostate Antibodies  >25 publications with BMP2 and Prostate
 Intestine Antibodies  >21 publications with BMP2 and Intestine
 Spleen Antibodies  >17 publications with BMP2 and Spleen
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