Rat C5A Recombinant Protein – Cat# MBS7615764

C5A Rat Recombinant Protein

Name: C5A Recombinant Protein; Rat; MyBioSource
Brand: MyBioSource
SKU: MBS7615764
Price: 430 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS7615764

MBS7615764 is a recombinant protein targeting C5A. Also known as Recombinant Rat C5A. Host: E Coli. More details

$430 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

C5A, Recombinant Protein

Full Product Name

Recombinant Rat C5A

Product Gene Name

C5A recombinant protein

Product Synonym Names

complement component 5a receptor 1

Host

E Coli

Form/Format

Lyophilized from a 0.2 um filtered solution in 10 mM Hepes, 500 mM NaCl with 5% trehalose and 0.06% proclin, pH7.4

Purity/Purification

Greater than 90% by SDS-PAGE gel analyses

Preparation and Storage

Store at -20 degree C for 12 months as lyophilized; 2-8 degree C for 1 month under sterile conditions after reconstitution

Molecular Weight

8,981 Da

Sequence Positions

679-755

3D Structure

ModBase 3D Structure for P08650

Species

Rat

Tag

N-terminal His-IF2DI Tag

Reconstitution

Centrifuge the vial at 10,000 rpm for 1 minute, reconstitute at 200 ug/ml in sterile distilled water by gentle pipetting 2-3 times, don't vortex

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Applications Tested/Suitable for C5A recombinant protein

Western Blot (WB), ELISA (EIA)

Other Notes

Small volumes of C5A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for C5A. It may not necessarily be applicable to this product.

NCBI GI #

46397770

NCBI GeneID

362119

NCBI Accession #

P08650.2

UniProt Primary Accession #

P08650

UniProt Secondary Accession #

Q63078

UniProt Related Accession #

P08650

NCBI Official Full Name

Complement C5

NCBI Official Synonym Full Names

complement component 5

NCBI Official Symbol

NCBI Official Synonym Symbols

Hc; C5a; RGD1561905

UniProt Protein Name

Complement C5

Protein Family

C5a anaphylatoxin chemotactic receptor

UniProt Gene Name

UniProt Entry Name

CO5_RAT

NCBI Protein Information

complement C5; anaphylatoxin

NCBI Summary for C5A

likely component of the classical pathway of the complement cascade; may be involved with tissue injury associated with ischemia or sepsis; may be a component of the membrane attack complex [RGD, Feb 2006]

UniProt Comments for C5A

C5: Activation of C5 by a C5 convertase initiates the spontaneous assembly of the late complement components, C5-C9, into the membrane attack complex. C5b has a transient binding site for C6. The C5b-C6 complex is the foundation upon which the lytic complex is assembled. Defects in C5 are the cause of complement component 5 deficiency (C5D). A rare defect of the complement classical pathway associated with susceptibility to severe recurrent infections, predominantly by Neisseria gonorrhoeae or Neisseria meningitidis. An association study of C5 haplotypes and genotypes in individuals with chronic hepatitis C virus infection shows that individuals homozygous for the C5_1 haplotype have a significantly higher stage of liver fibrosis than individuals carrying at least 1 other allele (PubMed:15995705).

Protein type: Secreted; Secreted, signal peptide

Cellular Component: extracellular space

Molecular Function: C5a anaphylatoxin chemotactic receptor binding

Biological Process: cellular calcium ion homeostasis; positive regulation of angiogenesis; positive regulation of chemotaxis; in utero embryonic development; complement activation, alternative pathway; glucose homeostasis; chemotaxis; inflammatory response; negative regulation of dopamine secretion; complement activation, classical pathway; leukocyte migration during inflammatory response

Research Articles on C5A

1. data indicate that the mechanism of IL-6 and TGF-beta1 production in renal tissue of Thy-1N rats is associated with sublytic C5b-9 up-regulated p300 and p300-mediated C/EBPbeta acetylation

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with C5A recombinant protein

Products by Pathway	Pathway Diagram
Activation Of C3 And C5 Pathway antibodies	Activation Of C3 And C5 Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Complement Activation, Classical Pathway antibodies	Complement Activation, Classical Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement Cascade Pathway antibodies	Complement Cascade Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
Herpes Simplex Infection Pathway antibodies	Herpes Simplex Infection Pathway Diagram

Organs/Tissues associated with C5A recombinant protein

Organ/Tissue Name	Pubmed Publications
Kidney Antibodies	>461 publications with C5A and Kidney
Liver Antibodies	>432 publications with C5A and Liver
Embryonic Tissue Antibodies	>63 publications with C5A and Embryonic Tissue
Adrenal Gland Antibodies	>10 publications with C5A and Adrenal Gland
Uncharacterized Tissue Antibodies	>2 publications with C5A and Uncharacterized Tissue