Human CANT1 Recombinant Protein – Cat# MBS2545398

CANT1 Human Recombinant Protein

Name: CANT1 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS2545398
Price: 700 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2545398

Background: CANT1 (calcium activated nucleotidase 1) belongs to the apyrase family. Apyrase is a calcium-activated plasma membrane-bound enzyme (magnesium can also activate it) (EC 3.6.1.5) that catalyses the hydrolysis of ATP to yield AMP and inorganic… More details

$700 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CANT1, Recombinant Protein

Full Product Name

Recombinant Human CANT1 Protein (Fc tag)

Product Gene Name

CANT1 recombinant protein

Product Synonym Names

CANT1, SHAPY

Host

Human Cells

Form/Format

Lyophilized from sterile PBS, pH 7.4

Purity/Purification

> 90 % as determined by SDS-PAGE

Preparation and Storage

Samples are stable for up to twelve months from date of receipt at -70 degree C

Molecular Weight

38,946 Da

OMIM

AF328554 mRNA

3D Structure

ModBase 3D Structure for Q8WVQ1

Predicted N Terminal

Glu

Endotoxin

< 1.0 EU per mug of the protein as determined by the LAL method

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Application Notes for CANT1 recombinant protein

The recombinant human CANT1/Fc is a disulfide-linked homodimer. The reduced monomer comprises 582 amino acids and has a predicted molecular mass of 64.3 kDa. The apparent molecular mass of the protein is approximately 65 kDa in SDS-PAGE under reducing conditions due to glycosylation.

Other Notes

Small volumes of CANT1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CANT1 purchase

MBS2545398 is a recombinant protein targeting CANT1. Also known as Recombinant Human CANT1 Protein (Fc tag). Host: Human Cells.

Additional Details

NCBI/Uniprot data below describe general gene information for CANT1. It may not necessarily be applicable to this product.

NCBI GI #

229577440

NCBI GeneID

124583

NCBI Accession #

NP_001153244.1

UniProt Primary Accession #

Q8WVQ1

UniProt Secondary Accession #

Q7Z2J7; Q8NG05; Q8NHP0; Q9BSD5; B4DJ54

UniProt Related Accession #

Q8WVQ1

GenBank Nucleotide #

NM_001159772.1

NCBI Official Full Name

soluble calcium-activated nucleotidase 1

NCBI Official Synonym Full Names

calcium activated nucleotidase 1

NCBI Official Symbol

CANT1

NCBI Official Synonym Symbols

DBQD; DBQD1; SCAN1; SHAPY; SCAN-1

UniProt Protein Name

Soluble calcium-activated nucleotidase 1

UniProt Synonym Protein Names

Apyrase homolog; Putative MAPK-activating protein PM09; Putative NF-kappa-B-activating protein 107

Protein Family

Soluble calcium-activated nucleotidase

UniProt Gene Name

CANT1

UniProt Synonym Gene Names

SHAPY; SCAN-1

NCBI Protein Information

soluble calcium-activated nucleotidase 1

NCBI Summary for CANT1

This protein encoded by this gene belongs to the apyrase family. It functions as a calcium-dependent nucleotidase with a preference for UDP. Mutations in this gene are associated with Desbuquois dysplasia with hand anomalies. Alternatively spliced transcript variants have been noted for this gene.[provided by RefSeq, Mar 2010]

UniProt Comments for CANT1

CANT1: Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis. Defects in CANT1 are the cause of Desbuquois dysplasia (DBQD). A chondrodysplasia characterized by severe prenatal and postnatal growth retardation (less than -5 SD), joint laxity, short extremities, progressive scoliosis, round face, midface hypoplasia, prominent bulging eyes. The main radiologic features are short long bones with metaphyseal splay, a 'Swedish key' appearance of the proximal femur (exaggerated trochanter), and advance carpal and tarsal bone age. Two forms of Desbuquois dysplasia are distinguished on the basis of the presence (type 1) or absence (type 2) of characteristic hand anomalies: an extra ossification center distal to the second metacarpal, delta phalanx, bifid distal thumb phalanx, and phalangeal dislocations. Belongs to the apyrase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.6.1.6; Endoplasmic reticulum; Hydrolase; Membrane protein, integral; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine

Chromosomal Location of Human Ortholog: 17q25.3

Cellular Component: membrane

Molecular Function: adenosine-diphosphatase activity; calcium ion binding; guanosine-diphosphatase activity; protein homodimerization activity; signal transducer activity; uridine-diphosphatase activity

Biological Process: positive regulation of I-kappaB kinase/NF-kappaB cascade; proteoglycan biosynthetic process

Disease: Desbuquois Dysplasia 1

Research Articles on CANT1

1. a novel mutation of CANT1, c.467C>T (p.Ser156Phe) in 3 Indian patients with Desbuquois dysplasia, Kim type from 2 families

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with CANT1 recombinant protein

Products by Pathway	Pathway Diagram
Purine Metabolism Pathway antibodies	Purine Metabolism Pathway Diagram
Purine Metabolism Pathway antibodies	Purine Metabolism Pathway Diagram
Pyrimidine Metabolism Pathway antibodies	Pyrimidine Metabolism Pathway Diagram
Pyrimidine Metabolism Pathway antibodies	Pyrimidine Metabolism Pathway Diagram
UTP And CTP Dephosphorylation II Pathway antibodies	UTP And CTP Dephosphorylation II Pathway Diagram

Diseases associated with CANT1 recombinant protein

Disease Name	Pubmed Publications
Congenital Abnormalities Antibodies	>6 publications with CANT1 and Congenital Abnormalities
Desbuquois syndrome Antibodies	>4 publications with CANT1 and Desbuquois syndrome
Death Antibodies	>2 publications with CANT1 and Death
Fetal Death Antibodies	>2 publications with CANT1 and Fetal Death
Edema Antibodies	>1 publications with CANT1 and Edema

Organs/Tissues associated with CANT1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Bone Antibodies	>5 publications with CANT1 and Bone
Prostate Antibodies	>3 publications with CANT1 and Prostate
Connective Tissue Antibodies	>1 publications with CANT1 and Connective Tissue
Lung Antibodies	>1 publications with CANT1 and Lung