CCR2 Mouse Recombinant Protein

CCR2: a seven transmembrane protein closely related to CCR1. Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. Transduces a signal by increasing the intracellular calcium ions level. Alternative co receptor with CD4 for HIV-1 infection. Two splice-variant isoforms have been described.

Protein type: Membrane protein, integral; GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR

Cellular Component: membrane; integral to plasma membrane; plasma membrane; integral to membrane; external side of plasma membrane

Molecular Function: G-protein coupled receptor activity; signal transducer activity; protein binding; C-C chemokine receptor activity; cytokine binding; chemokine receptor activity

Biological Process: positive regulation of T-helper 1 type immune response; signal transduction; sensory perception of pain; chemotaxis; regulation of cell migration; monocyte chemotaxis; hemopoiesis; angiogenesis; cellular homeostasis; inflammatory response; healing during inflammatory response; positive regulation of tumor necrosis factor biosynthetic process; cytokine and chemokine mediated signaling pathway; humoral immune response; G-protein coupled receptor protein signaling pathway; positive regulation of interferon-gamma production; negative regulation of angiogenesis; negative regulation of T-helper 2 type immune response; positive regulation of interleukin-2 production; cellular defense response; blood vessel remodeling; positive regulation of alpha-beta T cell proliferation; immune response; negative regulation of eosinophil degranulation; positive regulation of T cell activation; positive regulation of T-helper 1 cell differentiation; apoptotic cell clearance; positive regulation of inflammatory response