CD137L Recombinant Protein

Name: CD137L Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS566248
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS566248

The CD137 ligand (CD137L, 4-1BBL) is a member of the tumor necrosis factor (TNF) family. CD137L is a type II, transmembrane protein found on activated macrophages, dendritic cells and mature B cells. The interaction with its receptor 4-1BB induces recruitment… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CD137L, Recombinant Protein

Full Product Name

CD137L (soluble) (human), (recombinant)

Product Gene Name

CD137L recombinant protein

Host

HEK293 cells

Form/Format

Lyophilized. Contains PBS and 5% trehalose

Purity/Purification

>=95% (SDS-PAGE)

Concentration

0.1mg/ml after reconstitution (lot specific)

Specificity

Binds to human CD137 (4-1BB)

Preparation and Storage

Stable for at least 6 months after receipt when stored at -20 degree C
Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20 degree C
Shipping: Shipped on Blue Ice

Molecular Weight

33,853 Da

3D Structure

ModBase 3D Structure for P41274

Source Note

The extracellular domain of human CD137L (aa 49-254) is fused at the N-terminus to a linker peptide (10 aa) and a DYKDDDDK-tag

Endotoxin

<0.1EU/ug purified protein (LAL test)

Reconstitution

Reconstitute with 100ul sterile distilled water. Further dilutions should be made with medium containing 5% fetal calf serum

Product Categories/Family for CD137L recombinant protein

Cellular Analysis; Cell & Tissue Markers

Other Notes

Small volumes of CD137L recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD137L purchase

MBS566248 is a recombinant protein targeting CD137L. Also known as CD137L (soluble) (human), (recombinant). Host: HEK293 cells.

Additional Details

NCBI/Uniprot data below describe general gene information for CD137L. It may not necessarily be applicable to this product.

NCBI GI #

6678389

NCBI GeneID

21950

NCBI Accession #

NP_033430.1

UniProt Primary Accession #

P41274

UniProt Related Accession #

P41274

GenBank Nucleotide #

NM_009404.3

NCBI Official Full Name

tumor necrosis factor ligand superfamily member 9

NCBI Official Synonym Full Names

tumor necrosis factor (ligand) superfamily, member 9

NCBI Official Symbol

Tnfsf9

NCBI Official Synonym Symbols

Ly63l; 4-1BBL; Cd137l; 4-1BB-L; AI848817

UniProt Protein Name

Tumor necrosis factor ligand superfamily member 9

UniProt Synonym Protein Names

4-1BB ligand; 4-1BBL

UniProt Gene Name

Tnfsf9

UniProt Synonym Gene Names

Cd137l; Cd157l; Ly63l; 4-1BBL

UniProt Entry Name

TNFL9_MOUSE

NCBI Protein Information

tumor necrosis factor ligand superfamily member 9; 4-1BB ligand

UniProt Comments for CD137L

TNFL9: Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages. Belongs to the tumor necrosis factor family.

Protein type: Apoptosis; Cytokine; Membrane protein, integral; Cell cycle regulation

Cellular Component: extracellular space; membrane; integral to membrane; plasma membrane

Molecular Function: cytokine activity; tumor necrosis factor receptor superfamily binding; tumor necrosis factor receptor binding; receptor binding

Biological Process: positive regulation of interferon-gamma production; positive regulation of cytotoxic T cell differentiation; cell-cell signaling; positive regulation of interleukin-12 production; positive regulation of interleukin-6 production; myeloid dendritic cell differentiation; immune response; positive regulation of activated T cell proliferation; regulation of cell proliferation

Research Articles on CD137L

1. 4-1BB mediates the inflammatory responses in obese skeletal muscle by interacting with its ligand 4-1BBL on macrophages.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with CD137L recombinant protein

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram

Diseases associated with CD137L recombinant protein

Disease Name	Pubmed Publications
Necrosis Antibodies	>130 publications with CD137L and Necrosis
Disease Models, Animal Antibodies	>18 publications with CD137L and Disease Models, Animal
Inflammation Antibodies	>16 publications with CD137L and Inflammation
Gastrointestinal Diseases Antibodies	>14 publications with CD137L and Gastrointestinal Diseases
Neoplasms, Experimental Antibodies	>14 publications with CD137L and Neoplasms, Experimental
Liver Diseases Antibodies	>11 publications with CD137L and Liver Diseases
Cardiovascular Diseases Antibodies	>10 publications with CD137L and Cardiovascular Diseases
Liver Neoplasms Antibodies	>10 publications with CD137L and Liver Neoplasms
Carcinoma, Hepatocellular Antibodies	>5 publications with CD137L and Carcinoma, Hepatocellular
Lung Neoplasms Antibodies	>5 publications with CD137L and Lung Neoplasms

Organs/Tissues associated with CD137L recombinant protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>14 publications with CD137L and Liver
Lymph Node Antibodies	>9 publications with CD137L and Lymph Node
Lung Antibodies	>9 publications with CD137L and Lung
Skin Antibodies	>7 publications with CD137L and Skin
Brain Antibodies	>5 publications with CD137L and Brain
Stomach Antibodies	>3 publications with CD137L and Stomach
Connective Tissue Antibodies	>2 publications with CD137L and Connective Tissue
Embryonic Tissue Antibodies	>2 publications with CD137L and Embryonic Tissue
Thymus Antibodies	>1 publications with CD137L and Thymus