Mouse CD172a Recombinant Protein – Cat# MBS8305172

CD172a Mouse Recombinant Protein

Name: CD172a Recombinant Protein; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS8305172
Price: 290 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8305172

Recombinant Mouse CD172a Protein is produced by mammalian expression system and the target gene encoding Lys32-Asn372 is expressed with a Fc tag at the C-terminus. More details

$290 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CD172a, Recombinant Protein

Full Product Name

Recombinant Mouse CD172a Protein

Product Gene Name

CD172a recombinant protein

Product Synonym Gene Name

SIRPA

Product Synonym Names

BIT; MFR; MYD1; PTPNS1; SHPS1; SIRP; Tyrosine-protein phosphatase non-receptor type substrate 1; SHP substrate 1; SHPS-1; Brain Ig-like molecule with tyrosine-based activation motifs; Bit; CD172 antigen-like family member A; Inhibitory receptor SHPS-1; Macrophage fusion receptor; MyD-1 antigen; Signal-regulatory protein alpha-1; Sirp-alpha-1; Signal-regulatory protein alpha-2; Sirp-alpha-2; Signal-regulatory protein alpha-3; Sirp-alpha-3; p84; CD172a

Sequence

KELKVTQPEK SVSVAAGDST VLNCTLTSLL PVGPIRWYRG VGPSRLLIYS FAGEYVPRIR NVSDTTKRNN MDFSIRISNV TPADAGIYYC VKFQKGSSEP DTEIQSGGGT EVYVLAKPSP PEVSGPADRG IPDQKVNFTC KSHGFSPRNI TLKWFKDGQE LHPLETTVNP SGKNVSYNIS STVRVVLNSM DVNSKVICEV AHITLDRSPL RGIANLSNFI RVSPTVKVTQ QSPTSMNQVN LTCRAERFYP EDLQLIWLEN GNVSRNDTPK NLTKNTDGTY NYTSLFLVNS SAHREDVVFT CQVKHDQQPA ITRNHTVLGF AHSSDQGSMQ TFPDNNATHN WNVDDIEGRM DEPKSCDKTH TCPPCPAPEL LGGPSVFLFP PKPKDTLMIS RTPEVTCVVV DVSHEDPEVK FNWYVDGVEV HNAKTKPREE QYNSTYRVVS VLTVLHQDWL NGKEYKCKVS NKALPAPIEK TISKAKGQPR EPQVYTLPPS REEMTKNQVS LTCLVKGFYP SDIAVEWESN GQPENNYKTT PPVLDSDGSF FLYSKLTVDK SRWQQGNVFS CSVMHEALHN HYTQKSLSLS PGK

Host

Human Cells

Form/Format

Lyophilized from a 0.2 mum filtered solution of PBS, pH7.4.

Purity/Purification

>95% as determined by reducing SDS-PAGE

Preparation and Storage

Lyophilized protein should be stored at -20 degree C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 2-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at -20 degree C for 3 months.

3D Structure

ModBase 3D Structure for P97797

Endotoxin

Less than 0.1 ng/ug (1 IEU/ug) as determined by LAL test.

Applications Tested/Suitable for CD172a recombinant protein

ELISA (EIA), Western Blot (WB), SDS-PAGE

Other Notes

Small volumes of CD172a recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD172a purchase

MBS8305172 is a recombinant protein targeting CD172a. Also known as Recombinant Mouse CD172a Protein. Host: Human Cells.

Additional Details

NCBI/Uniprot data below describe general gene information for CD172a. It may not necessarily be applicable to this product.

NCBI GI #

294997315

NCBI GeneID

19261

NCBI Accession #

NP_001171117.1

UniProt Primary Accession #

P97797

UniProt Related Accession #

P97797

NCBI Official Synonym Full Names

signal-regulatory protein alpha

NCBI Official Symbol

Sirpa

NCBI Official Synonym Symbols

Bit; P84; SIRP; SHP-1; CD172a; Ptpns1; SHPS-1; AI835480

UniProt Protein Name

Tyrosine-protein phosphatase non-receptor type substrate 1

UniProt Synonym Protein Names

Brain Ig-like molecule with tyrosine-based activation motifs; Bit; CD172 antigen-like family member A; Inhibitory receptor SHPS-1; MyD-1 antigen; Signal-regulatory protein alpha-1; Sirp-alpha-1; mSIRP-alpha1; p84

Protein Family

Tyrosine-protein phosphatase non-receptor

UniProt Gene Name

Sirpa

UniProt Synonym Gene Names

Bit; Myd1; Ptpns1; Shps1; Sirp; SHP substrate 1; SHPS-1; Bit; Sirp-alpha-1

UniProt Entry Name

SHPS1_MOUSE

NCBI Protein Information

tyrosine-protein phosphatase non-receptor type substrate 1

UniProt Comments for CD172a

Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function. Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells ().

Research Articles on CD172a

1. this study shows that miR-378a modulates macrophage phagocytosis and differentiation through targeting CD47-SIRPalpha axis in atherosclerosis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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