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CD22 Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS188061

B-cell receptor CD22 is also known as Sialic acid-binding Ig-like lectin 2 (Siglec-2), B-lymphocyte cell adhesion molecule (BL-CAM), T-cell surface antigen Leu-14, which belongs to the immunoglobulin superfamily and SIGLEC (sialic acid binding Ig-like lectin)… More details

$290 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CD22, Recombinant Protein
Full Product Name
Recombinant human CD22 protein with C-terminal human Fc and 6xHis tag
Product Gene Name
CD22 recombinant protein
Product Synonym Names
Human CD22 Protein, hFc-His Tag; CD22; SIGLEC2; BL-CAM; SIGLEC-2; Siglec2; SIGLEC2FLJ22814
Sequence
CD22(Asp20 -Arg687)+h Fc(Glu99-A la330)
Host
HEK293 cells
Form/Format
Lyophilized from sterile PBS, pH 7.4. Normally 5%-12% trehalose is added as protectants before lyophilization.
Purity/Purification
The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Preparation and Storage
Store at -80 degree C for 12 months (Avoid repeated freezing and thawing)
Shipping: Blue Ice
Matching Pairs
Antibody: CD22 Clone #DM13 (MBS188034)
Antigen: CD22 (MBS188061)
Molecular Weight
95,348 Da
Chromosome Location
Chromosome: 19; NC_000019.9 (35820072..35838264). Location: 19q13.1
OMIM
107266
3D Structure
ModBase 3D Structure for P20273
Source
Human
Conjugation
C-Human Fc and 6xHis tag
Reconstitution
Reconstitute with deionized water
Applications Tested/Suitable for CD22 recombinant protein
Western Blot (WB)

ELISA (EIA) of CD22 recombinant protein

Figure 1. Human CD22, hFc-His Tag on SDS-PAGE under reducing condition.
CD22 Recombinant Protein – Cat# MBS188061

SDS-Page of CD22 recombinant protein

Figure 1. Human CD22, hFc-His Tag on SDS-PAGE under reducing condition.
CD22 Recombinant Protein, SDS-Page – Cat# MBS188061

Other Notes

Small volumes of CD22 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD22 purchase

MBS188061 is a recombinant protein targeting CD22. Also known as Recombinant human CD22 protein with C-terminal human Fc and 6xHis tag. Host: HEK293 cells.

Additional Details

NCBI/Uniprot data below describe general gene information for CD22. It may not necessarily be applicable to this product.

NCBI GI #
297374825
NCBI GeneID
933
NCBI Accession #
NP_001172028.1
UniProt Primary Accession #
P20273
UniProt Secondary Accession #
O95699; O95701; O95702; O95703; Q01665; Q92872; Q92873; Q9UQA6; Q9UQA7; Q9UQA8; F5H7U3
UniProt Related Accession #
P20273
GenBank Nucleotide #
NM_001185099.1
NCBI Official Full Name
B-cell receptor CD22 isoform 2
NCBI Official Synonym Full Names
CD22 molecule
NCBI Official Symbol
CD22
NCBI Official Synonym Symbols
SIGLEC2; SIGLEC-2
UniProt Protein Name
B-cell receptor CD22
UniProt Synonym Protein Names
B-lymphocyte cell adhesion molecule; BL-CAM; Sialic acid-binding Ig-like lectin 2; Siglec-2; T-cell surface antigen Leu-14
Protein Family
B-cell receptor
UniProt Gene Name
CD22
UniProt Synonym Gene Names
SIGLEC2; BL-CAM; Siglec-2
UniProt Entry Name
CD22_HUMAN
NCBI Protein Information
B-cell receptor CD22; BL-CAM; CD22 antigen; T-cell surface antigen Leu-14; B-lymphocyte cell adhesion molecule; sialic acid binding Ig-like lectin 2; sialic acid-binding Ig-like lectin 2

UniProt Comments for CD22

CD22: Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules. Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell surface; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19q13.1

Cellular Component: integral to plasma membrane; external side of plasma membrane

Molecular Function: protein binding; carbohydrate binding

Biological Process: cell adhesion
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Research Articles on CD22

1. In the absence of functional CD22, B cells have a "hyperactivated" phenotype, CD22 dysfunction could contribute to the pathogenesis of autoimmune diseases. (Review)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CD22 recombinant protein

 Reference Product  PubMed Publications
 CD19 recombinant protein  >563 publications with CD22 and CD19
 PTPRC recombinant protein  >116 publications with CD22 and PTPRC
 LYN recombinant protein  >40 publications with CD22 and LYN
 PTPN6 recombinant protein  >36 publications with CD22 and PTPN6
 SYK recombinant protein  >25 publications with CD22 and SYK
 GRB2 recombinant protein  >6 publications with CD22 and GRB2
 ST6GAL1 recombinant protein  >3 publications with CD22 and ST6GAL1
 IGHM recombinant protein  >2 publications with CD22 and IGHM
 SHC1 recombinant protein  >1 publications with CD22 and SHC1

Pathways associated with CD22 recombinant protein

 Products by Pathway  Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 B Cell Receptor Signaling Pathway antibodies  B Cell Receptor Signaling Pathway Diagram
 BCR Signaling Pathway antibodies  BCR Signaling Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram

Diseases associated with CD22 recombinant protein

 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >891 publications with CD22 and Immune System Diseases
 Neoplasms Antibodies  >866 publications with CD22 and Neoplasms
 Neoplasms, Experimental Antibodies  >102 publications with CD22 and Neoplasms, Experimental
 Drug Toxicity Antibodies  >70 publications with CD22 and Drug Toxicity
 Necrosis Antibodies  >50 publications with CD22 and Necrosis
 Inflammation Antibodies  >49 publications with CD22 and Inflammation
 Bone Marrow Diseases Antibodies  >38 publications with CD22 and Bone Marrow Diseases
 Nervous System Diseases Antibodies  >38 publications with CD22 and Nervous System Diseases
 Cell Transformation, Neoplastic Antibodies  >22 publications with CD22 and Cell Transformation, Neoplastic
 Kidney Diseases Antibodies  >20 publications with CD22 and Kidney Diseases

Organs/Tissues associated with CD22 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >983 publications with CD22 and Blood
 Bone Marrow Antibodies  >273 publications with CD22 and Bone Marrow
 Spleen Antibodies  >118 publications with CD22 and Spleen
 Lymph Node Antibodies  >105 publications with CD22 and Lymph Node
 Lymph Antibodies  >97 publications with CD22 and Lymph
 Skin Antibodies  >46 publications with CD22 and Skin
 Thymus Antibodies  >31 publications with CD22 and Thymus
 Tonsil Antibodies  >29 publications with CD22 and Tonsil
 Kidney Antibodies  >29 publications with CD22 and Kidney
 Lung Antibodies  >28 publications with CD22 and Lung
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