Human CD30 Recombinant Protein – Cat# MBS146726

CD30 Ligand (CD30) Human Recombinant Protein

Name: CD30 Recombinant Protein; CD30 Ligand; Human; MyBioSource
Brand: MyBioSource
SKU: MBS146726
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS146726

Description: TNFSF8 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 181 amino acids (63-234a.a.) and having a molecular mass of 20.7kDa (Molecular size on SDS-PAGE will appear at approximately 18-40kDa). TNFSF8 is… More details

$250 / 0.001 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CD30 Ligand, Recombinant Protein

Full Product Name

Recombinant Human CD30 Ligand, Sf9

Product Gene Name

CD30 recombinant protein

Product Synonym Names

TNFSF8 Human, Sf9; Tumor Necrosis Factor Superfamily Member 8; Tumor Necrosis Factor (Ligand) Superfamily; Member 8; CD153 Antigen; CD30 Ligand; CD30LG; CD30-L; CD30L; Tumor Necrosis Factor (Ligand) Superfamily Member 8; Tumor Necrosis Factor Ligand 3A; CD30 Antigen Ligand; TNLG3A; CD153; Tumor necrosis factor ligand superfamily member 8; TNFSF8; CD30 ligand; CD30 Ligand Human Recombinant, Sf9

Sequence

ADP QRTDSIPNSP DNVPLKG GNCSEDLLCI LKRAPFKKSW AYLQVAKHLN KTKLSWNKDG ILHGVRYQDG NLVIQFPGLY FIICQLQFLV QCPNNSVDLK LELLINKHIK KQALVTVCES GMQTKHVYQN LSQFLLDYLQ VNTTISVNVD TFQYIDTSTF PLENVLSIFL YSNSDHH HHH H.

Host

Sf9, Baculovirus cells

Form/Format

Sterile filtered colorless solution.
TNFSF8 protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol.

Purity/Purification

Greater than 85% as determined by SDS-PAGE.

Preparation and Storage

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

Molecular Weight

26,017 Da

OMIM

L09753 mRNA

3D Structure

ModBase 3D Structure for P32971

Product Categories/Family for CD30 recombinant protein

Cytokines and Growth Factors

Other Notes

Small volumes of CD30 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD30 purchase

MBS146726 is a recombinant protein targeting CD30. Also known as Recombinant Human CD30 Ligand, Sf9. Host: Sf9, Baculovirus cells.

Additional Details

NCBI/Uniprot data below describe general gene information for CD30. It may not necessarily be applicable to this product.

NCBI GI #

4507607

NCBI GeneID

944

NCBI Accession #

NP_001235.1

UniProt Primary Accession #

P32971

UniProt Secondary Accession #

O43404

UniProt Related Accession #

P32971

GenBank Nucleotide #

NM_001244.3

NCBI Official Full Name

tumor necrosis factor ligand superfamily member 8 isoform 1

NCBI Official Synonym Full Names

tumor necrosis factor superfamily member 8

NCBI Official Symbol

TNFSF8

NCBI Official Synonym Symbols

CD153; CD30L; CD30LG; TNLG3A

UniProt Protein Name

Tumor necrosis factor ligand superfamily member 8

UniProt Synonym Protein Names

CD30 ligand; CD30-L; CD_antigen: CD153

Protein Family

Tumor necrosis factor ligand superfamily

UniProt Gene Name

TNFSF8

UniProt Synonym Gene Names

CD30L; CD30LG; CD30-L

NCBI Protein Information

tumor necrosis factor ligand superfamily member 8

NCBI Summary for CD30

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF8/CD30, which is a cell surface antigen and a marker for Hodgkin lymphoma and related hematologic malignancies. The engagement of this cytokine expressed on B cell surface plays an inhibitory role in modulating Ig class switch. This cytokine was shown to enhance cell proliferation of some lymphoma cell lines, while to induce cell death and reduce cell proliferation of other lymphoma cell lines. The pleiotropic biologic activities of this cytokine on different CD30+ lymphoma cell lines may play a pathophysiologic role in Hodgkin's and some non-Hodgkin's lymphomas. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

UniProt Comments for CD30

TNFSF8: Cytokine that binds to TNFRSF8/CD30. Induces proliferation of T-cells. Belongs to the tumor necrosis factor family.

Protein type: Apoptosis; Cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 9q32-q33.1

Cellular Component: integral to plasma membrane

Molecular Function: receptor binding

Biological Process: apoptosis; cell proliferation; cell-cell signaling; signal transduction

Research Articles on CD30

1. circulant sCD30L is functionally active and that it may favor persistence of active inflammation by inducing apoptosis of CD30(+)T cells, known to down-modulate inflammation in rheumatoid synovitis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CD30 recombinant protein

Reference Product	PubMed Publications
TNFRSF8 recombinant protein	>2 publications with CD30 and TNFRSF8
ANG recombinant protein	>1 publications with CD30 and ANG

Pathways associated with CD30 recombinant protein

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram

Diseases associated with CD30 recombinant protein

Disease Name	Pubmed Publications
Necrosis Antibodies	>55 publications with CD30 and Necrosis
Neoplasms Antibodies	>52 publications with CD30 and Neoplasms
Leukemia Antibodies	>18 publications with CD30 and Leukemia
Inflammation Antibodies	>8 publications with CD30 and Inflammation
Carcinoma Antibodies	>5 publications with CD30 and Carcinoma
Skin Neoplasms Antibodies	>4 publications with CD30 and Skin Neoplasms
Drug Toxicity Antibodies	>3 publications with CD30 and Drug Toxicity
Lung Neoplasms Antibodies	>3 publications with CD30 and Lung Neoplasms
Multiple Myeloma Antibodies	>3 publications with CD30 and Multiple Myeloma
Breast Neoplasms Antibodies	>2 publications with CD30 and Breast Neoplasms

Organs/Tissues associated with CD30 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>64 publications with CD30 and Blood
Lung Antibodies	>6 publications with CD30 and Lung
Pancreas Antibodies	>1 publications with CD30 and Pancreas