Human CD33 Recombinant Protein – Cat# MBS1883923

Figure 1. Human CD33(18-259) Protein, His Tag on SDS-PAGE under reducing condition.

CD33 Human Recombinant Protein

Name: CD33 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS1883923
Price: 300 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1883923

Enables protein phosphatase binding activity and sialic acid binding activity. Involved in several processes, including negative regulation of cytokine production; negative regulation of monocyte activation; and positive regulation of protein tyrosine… More details

$300 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CD33, Recombinant Protein

Full Product Name

Human CD33 (18-259) Protein, His Tag

Product Gene Name

CD33 recombinant protein

Product Synonym Names

p67; SIGLEC3; SIGLEC-3; Recombinant human CD33 (18-259) Protein with C-terminal 10×His tag

Sequence

CD33 (Asp18-His 259)

Host

HEK293

Form/Format

Lyophilized from sterile PBS, pH 7.4. Normally 5%-8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions of reconstitution.

Purity/Purification

The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.

Preparation and Storage

Store at -20 degree C to -80 degree C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80 degree C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.

Molecular Weight

Calculated MW: 25kDa/33kDa/39kDa
Observed MW: 77kDa

OMIM

159590

3D Structure

ModBase 3D Structure for P20138

Tag

C-10×His

Product Categories/Family for CD33 recombinant protein

ECD Proteins

Other Notes

Small volumes of CD33 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD33 purchase

MBS1883923 is a recombinant protein targeting CD33. Also known as Human CD33 (18-259) Protein, His Tag. Host: HEK293.

Additional Details

NCBI/Uniprot data below describe general gene information for CD33. It may not necessarily be applicable to this product.

NCBI GI #

116241290

NCBI GeneID

945

NCBI Accession #

P20138.2

UniProt Primary Accession #

P20138

UniProt Secondary Accession #

Q8TD24; B4E3P8; C9JEN7; F8WAL2

UniProt Related Accession #

P20138

NCBI Official Full Name

Myeloid cell surface antigen CD33

NCBI Official Synonym Full Names

CD33 molecule

NCBI Official Symbol

CD33

NCBI Official Synonym Symbols

p67; SIGLEC3; SIGLEC-3

UniProt Protein Name

Myeloid cell surface antigen CD33

UniProt Synonym Protein Names

Sialic acid-binding Ig-like lectin 3; Siglec-3; gp67; CD_antigen: CD33

Protein Family

Myeloid cell surface antigen

UniProt Gene Name

CD33

UniProt Synonym Gene Names

SIGLEC3; Siglec-3

UniProt Entry Name

CD33_HUMAN

NCBI Protein Information

myeloid cell surface antigen CD33; gp67; CD33 antigen (gp67); sialic acid binding Ig-like lectin 3; sialic acid-binding Ig-like lectin 3

UniProt Comments for CD33

CD33: Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro). Belongs to the immunoglobulin superfamily. SIGLEC (sialic acid binding Ig-like lectin) family.

Protein type: Membrane protein, integral; Cell adhesion

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: integral to plasma membrane; plasma membrane; external side of plasma membrane

Molecular Function: protein binding; receptor activity; carbohydrate binding

Biological Process: negative regulation of cell proliferation; cell-cell signaling; signal transduction; cell adhesion

Research Articles on CD33

1. The rs3865444(C) risk allele is strongly associated with greater expression of CD33 exon 2 and increased Alzheimer's disease susceptibility. [Meta-analysis]

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CD33 recombinant protein

Reference Product	PubMed Publications
CD34 recombinant protein	>1065 publications with CD33 and CD34
SRC recombinant protein	>20 publications with CD33 and SRC
PTPN11 recombinant protein	>11 publications with CD33 and PTPN11
PTPN6 recombinant protein	>7 publications with CD33 and PTPN6
CBL recombinant protein	>3 publications with CD33 and CBL
UBC recombinant protein	>3 publications with CD33 and UBC
PVR recombinant protein	>1 publications with CD33 and PVR

Pathways associated with CD33 recombinant protein

Products by Pathway	Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram

Diseases associated with CD33 recombinant protein

Disease Name	Pubmed Publications
Leukemia, Myeloid Antibodies	>1323 publications with CD33 and Leukemia, Myeloid
Leukemia, Myeloid, Acute Antibodies	>1160 publications with CD33 and Leukemia, Myeloid, Acute
Necrosis Antibodies	>92 publications with CD33 and Necrosis
Death Antibodies	>78 publications with CD33 and Death
Cardiovascular Diseases Antibodies	>77 publications with CD33 and Cardiovascular Diseases
Inflammation Antibodies	>67 publications with CD33 and Inflammation
Respiratory Tract Diseases Antibodies	>44 publications with CD33 and Respiratory Tract Diseases
Brain Diseases Antibodies	>40 publications with CD33 and Brain Diseases
Breast Neoplasms Antibodies	>39 publications with CD33 and Breast Neoplasms
Leukocytosis Antibodies	>32 publications with CD33 and Leukocytosis

Organs/Tissues associated with CD33 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>1414 publications with CD33 and Blood
Bone Antibodies	>982 publications with CD33 and Bone
Bone Marrow Antibodies	>971 publications with CD33 and Bone Marrow
Liver Antibodies	>85 publications with CD33 and Liver
Lymph Node Antibodies	>53 publications with CD33 and Lymph Node
Lung Antibodies	>50 publications with CD33 and Lung
Brain Antibodies	>31 publications with CD33 and Brain
Thymus Antibodies	>29 publications with CD33 and Thymus
Kidney Antibodies	>19 publications with CD33 and Kidney
Prostate Antibodies	>10 publications with CD33 and Prostate