CD81 Recombinant Protein

Name: CD81 Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS8121648
Price: 415 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS8121648

Background: CD81, also known as TAPA-1, belongs to the transmembrane 4 superfamily, also known as the tetraspanin family. Members of this family mediate signal transduction events that play a role in the regulation of cell development, activation, growth and… More details

$415 / 0.1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CD81, Recombinant Protein

Full Product Name

CD81 Protein, Human, Recombinant (mFc Tag)

Product Gene Name

CD81 recombinant protein

Product Synonym Names

Human CD81/TAPA-1 Protein (Fc Tag); CVID6 Protein, Human; S5.7 Protein, Human; TAPA1 Protein, Human; TSPAN28 Protein, Human; CD81 molecule

Sequence

Phe113-Lys 201

Host

HEK293 Cells

Form/Format

Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization. Please refer to the specific buffer information in the hard copy of CoA.

Purity/Purification

>95% as determined by SDS-PAGE

Preparation and Storage

Samples are stable for up to twelve months from date of receipt at -20 degree C to -80 degree C. Store it under sterile conditions at -20 degree C to -80 degree C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
In general, recombinant proteins are provided as lyophilized powder which are shipped at ambient temperature. Bulk packages of recombinant proteins are provided as frozen liquid.
They are shipped out with blue ice.

Molecular Weight

25,809 Da

OMIM

M33680 mRNA

3D Structure

ModBase 3D Structure for P60033

Species

Human

Endotoxin

<1.0EU per ug of the protein as determined by the LAL method

Predicted N Terminal

Asp

Tag

N-mouse IgG1-Fc

Protein Construction

A DNA sequence encoding the human CD81 (NP_004347.1)(Phe113-Lys201) was expressed with the Fc region of mouse IgG1 at the N-terminus.

Reconstitution

A hardcopy of COA with reconstitution instruction is sent along with the products. Please refer to it for detailed information.

Product References and Citations for CD81 recombinant protein

Petracca R. et al., 2000, J Virol. 74 (10): 4824-30. Bartosch B. et al., 2003, The Journal of Biological Chemistry. 278 (43): 41624-30. Clark KL. et al., 2001, Journal of Immunology. 167 (9): 5115-21.

Other Notes

Small volumes of CD81 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD81 purchase

MBS8121648 is a recombinant protein targeting CD81. Also known as CD81 Protein, Human, Recombinant (mFc Tag). Host: HEK293 Cells.

Additional Details

NCBI/Uniprot data below describe general gene information for CD81. It may not necessarily be applicable to this product.

NCBI GI #

4757944

NCBI GeneID

975

NCBI Accession #

NP_004347.1

UniProt Primary Accession #

P60033

UniProt Secondary Accession #

P18582; Q5U0J6

UniProt Related Accession #

P60033

GenBank Nucleotide #

NM_004356.3

NCBI Official Full Name

CD81 antigen isoform 1

NCBI Official Synonym Full Names

CD81 molecule

NCBI Official Symbol

CD81

NCBI Official Synonym Symbols

S5.7; CVID6; TAPA1; TSPAN28

UniProt Protein Name

CD81 antigen

UniProt Synonym Protein Names

26 kDa cell surface protein TAPA-1; Target of the antiproliferative antibody 1; Tetraspanin-28; Tspan-28; CD_antigen: CD81

Protein Family

CD81 antigen

UniProt Gene Name

CD81

UniProt Synonym Gene Names

TAPA1; TSPAN28; Tspan-28

NCBI Protein Information

CD81 antigen; tspan-28; tetraspanin-28; 26 kDa cell surface protein TAPA-1; CD81 antigen (target of antiproliferative antibody 1)

NCBI Summary for CD81

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

UniProt Comments for CD81

May play an important role in the regulation of lymphoma cell growth. Interacts with a 16-kDa Leu-13 protein to form a complex possibly involved in signal transduction. May act as the viral receptor for HCV.(Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes. Associates with CLDN1 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell.

Research Articles on CD81

1. CLEC4M and CD81 both are still crucial for hepatitis C virus entry into hepatocytes.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CD81 recombinant protein

Reference Product	PubMed Publications
CD19 recombinant protein	>96 publications with CD81 and CD19
CLDN1 recombinant protein	>89 publications with CD81 and CLDN1
CD4 recombinant protein	>69 publications with CD81 and CD4
IGSF8 recombinant protein	>16 publications with CD81 and IGSF8
CR2 recombinant protein	>16 publications with CD81 and CR2
PTGFRN recombinant protein	>13 publications with CD81 and PTGFRN
ITGA4 recombinant protein	>2 publications with CD81 and ITGA4
IFITM1 recombinant protein	>2 publications with CD81 and IFITM1

Pathways associated with CD81 recombinant protein

Products by Pathway	Pathway Diagram
Adaptive Immune System Pathway antibodies	Adaptive Immune System Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
Hepatitis C Pathway antibodies	Hepatitis C Pathway Diagram
Hepatitis C Pathway antibodies	Hepatitis C Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway antibodies	Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway Diagram
Malaria Pathway antibodies	Malaria Pathway Diagram
Malaria Pathway antibodies	Malaria Pathway Diagram

Diseases associated with CD81 recombinant protein

Disease Name	Pubmed Publications
Hepatitis C Antibodies	>521 publications with CD81 and Hepatitis C
Liver Diseases Antibodies	>246 publications with CD81 and Liver Diseases
Carcinoma Antibodies	>101 publications with CD81 and Carcinoma
Carcinoma, Hepatocellular Antibodies	>74 publications with CD81 and Carcinoma, Hepatocellular
Liver Neoplasms Antibodies	>50 publications with CD81 and Liver Neoplasms
Adenocarcinoma Antibodies	>45 publications with CD81 and Adenocarcinoma
Liver Cirrhosis Antibodies	>41 publications with CD81 and Liver Cirrhosis
Inflammation Antibodies	>38 publications with CD81 and Inflammation
Vascular Diseases Antibodies	>27 publications with CD81 and Vascular Diseases
Necrosis Antibodies	>24 publications with CD81 and Necrosis

Organs/Tissues associated with CD81 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>335 publications with CD81 and Blood
Liver Antibodies	>239 publications with CD81 and Liver
Bone Antibodies	>46 publications with CD81 and Bone
Bone Marrow Antibodies	>40 publications with CD81 and Bone Marrow
Brain Antibodies	>38 publications with CD81 and Brain
Kidney Antibodies	>25 publications with CD81 and Kidney
Lung Antibodies	>25 publications with CD81 and Lung
Vascular Antibodies	>22 publications with CD81 and Vascular
Lymph Node Antibodies	>18 publications with CD81 and Lymph Node
Nerve Antibodies	>16 publications with CD81 and Nerve