Mouse C8A Recombinant Protein – Cat# MBS1469880

Complement Component C8 Alpha Chain (C8A) Mouse Recombinant Protein

Name: C8A Recombinant Protein; Mouse; MyBioSource
Brand: MyBioSource
SKU: MBS1469880
Price: 1350 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1469880

C8 is a component of the complement system and contains three polypeptides, alpha, beta and gamma. This gene encodes the alpha subunit of C8. C8 participates in the formation of the membrane attack complex (MAC). The MAC assembles on bacterial membranes to… More details

$1350 / 0.02 mg (E-Coli) +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Complement component C8 alpha chain (C8a), Recombinant Protein

Full Product Name

Recombinant Mouse Complement component C8 alpha chain (C8a)

Product Gene Name

C8a recombinant protein

Product Synonym Gene Name

C8a

Sequence

AVTPQAVSCQ LSDWYKWTDC FPCQDKKYRY RSLLQPSKFG GTICSGDIWD EASCDSPTPC LRQAQCGQDF QCRETGRCLK RHLVCNGDND CLDGSDESDC EDVRVTEDDC HQYEPIPGSE RAALGYNILT QEEAQSVYDA KYYGGQCETV YNGDWRKLRY DPTCERLYYG EDEKYFRKPY NFLKYHFEAL ADTSISSEFY DDANDLFFHI KNGKSHSAGV TVGVAPVKSP VSIEVTGSGS KASSFLNKLN KYNEKRYGFM RVSTKIQTAQ FKMRRNNIVL DEGMLQSLME LPEQFNYGMY AKFINDYGTH YITSGTMGGI YEYVMVLDKE KMKTEGTTVD EVQKCIGGGI GIGIKDSTIE GVGISGEFCE NSGDGDRDIR KKITGVEDII SRVQGGSSVW GSVLTHNSSA ITYQSWGRSL KYNPVVIDFE MQPIYQLLRH TNLGPLETKR QNLRRALDQY LMEFNACRCG PCFNNGEPIL DGTNCRCQCS MGRQGLACER TVIEGLKDFK AAGHWSCWSS WSECRGGSQE RRRQCNNPPP KNGGTPCLGR NLQTQAC

Host

E Coli or Yeast or Baculovirus or Mammalian Cell

Form/Format

Lyophilized or liquid (Format to be determined during the manufacturing process)

Purity/Purification

Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)

Preparation and Storage

Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Molecular Weight

66,080 Da

Sequence Positions

31-587, Full length protein

Tag Information

This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.

Sterility

Sterile filter available upon request.

Endotoxin

Low endotoxin available upon request.

3D Structure

ModBase 3D Structure for Q8K182

Species

Mouse

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of C8a recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for C8a purchase

MBS1469880 is a recombinant protein targeting C8a. Also known as Recombinant Mouse Complement component C8 alpha chain (C8a). Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for C8a. It may not necessarily be applicable to this product.

NCBI GI #

22122667

NCBI GeneID

230558

NCBI Accession #

NP_666260.1

UniProt Primary Accession #

Q8K182

UniProt Secondary Accession #

Q8CHJ9; Q8CHK1

UniProt Related Accession #

Q8K182

GenBank Nucleotide #

NM_146148.2

NCBI Official Full Name

complement component C8 alpha chain isoform 1 preproprotein

NCBI Official Synonym Full Names

complement component 8, alpha polypeptide

NCBI Official Symbol

C8a

UniProt Protein Name

Complement component C8 alpha chain

UniProt Synonym Protein Names

Complement component 8 subunit alpha

Protein Family

Complement component

UniProt Gene Name

C8a

NCBI Protein Information

complement component C8 alpha chain

NCBI Summary for C8a

This gene encodes the alpha subunit of complement component C8 that participates in the assembly of the complement membrane attack complex. The encoded preproprotein undergoes proteolytic processing to generate the alpha subunit, which associates with the beta and gamma subunits to form a trimeric complement component, C8. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. This gene is located adjacent to the gene encoding the beta subunit. [provided by RefSeq, Oct 2015]

UniProt Comments for C8a

Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself ().

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with C8a recombinant protein

Products by Pathway	Pathway Diagram
Amoebiasis Pathway antibodies	Amoebiasis Pathway Diagram
Amoebiasis Pathway antibodies	Amoebiasis Pathway Diagram
Complement Activation, Classical Pathway antibodies	Complement Activation, Classical Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement And Coagulation Cascades Pathway antibodies	Complement And Coagulation Cascades Pathway Diagram
Complement Cascade Pathway antibodies	Complement Cascade Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
Prion Diseases Pathway antibodies	Prion Diseases Pathway Diagram
Prion Diseases Pathway antibodies	Prion Diseases Pathway Diagram

Diseases associated with C8a recombinant protein

Disease Name	Pubmed Publications
Meningitis Antibodies	>3 publications with C8a and Meningitis
Inflammation Antibodies	>2 publications with C8a and Inflammation
Nervous System Diseases Antibodies	>2 publications with C8a and Nervous System Diseases
Drug Toxicity Antibodies	>2 publications with C8a and Drug Toxicity
Neisseriaceae Infections Antibodies	>2 publications with C8a and Neisseriaceae Infections
Neoplasms Antibodies	>1 publications with C8a and Neoplasms
Mental Disorders Antibodies	>1 publications with C8a and Mental Disorders
Brain Diseases Antibodies	>1 publications with C8a and Brain Diseases
COMPLEMENT COMPONENT 8 DEFICIENCY, TYPE I Antibodies	>1 publications with C8a and COMPLEMENT COMPONENT 8 DEFICIENCY, TYPE I

Organs/Tissues associated with C8a recombinant protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>4 publications with C8a and Liver
Mixed Antibodies	>3 publications with C8a and Mixed
Muscle Antibodies	>1 publications with C8a and Muscle