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Cullin-4a (CUL4A) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1385659

MBS1385659 is a recombinant protein targeting CUL4A. Also known as Recombinant Human Cullin-4A (CUL4A). Host: E Coli or Yeast or Baculovirus or Mammalian Cell. More details

$1625 / 0.02 mg (E-Coli) +2 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Cullin-4A (CUL4A), Recombinant Protein
Full Product Name
Recombinant Human Cullin-4A (CUL4A)
Product Gene Name
CUL4A recombinant protein
Product Synonym Gene Name
CUL4A
Sequence
MADEAPRKGS FSALVGRTNG LTKPAALAAA PAKPGGAGGS KKLVIKNFRD RPRLPDNYTQ DTWRKLHEAV RAVQSSTSIR YNLEELYQAV ENLCSHKVSP MLYKQLRQAC EDHVQAQILP FREDSLDSVL FLKKINTCWQ DHCRQMIMIR SIFLFLDRTY VLQNSTLPSI WDMGLELFRT HIISDKMVQS KTIDGILLLI ERERSGEAVD RSLLRSLLGM LSDLQVYKDS FELKFLEETN CLYAAEGQRL MQEREVPEYL NHVSKRLEEE GDRVITYLDH STQKPLIACV EKQLLGEHLT AILQKGLDHL LDENRVPDLA QMYQLFSRVR GGQQALLQHW SEYIKTFGTA IVINPEKDKD MVQDLLDFKD KVDHVIEVCF QKNERFVNLM KESFETFINK RPNKPAELIA KHVDSKLRAG NKEATDEELE RTLDKIMILF RFIHGKDVFE AFYKKDLAKR LLVGKSASVD AEKSMLSKLK HECGAAFTSK LEGMFKDMEL SKDIMVHFKQ HMQNQSDSGP IDLTVNILTM GYWPTYTPME VHLTPEMIKL QEVFKAFYLG KHSGRKLQWQ TTLGHAVLKA EFKEGKKEFQ VSLFQTLVLL MFNEGDGFSF EEIKMATGIE DSELRRTLQS LACGKARVLI KSPKGKEVED GDKFIFNGEF KHKLFRIKIN QIQMKETVEE QVSTTERVFQ DRQYQIDAAI VRIMKMRKTL GHNLLVSELY NQLKFPVKPG DLKKRIESLI DRDYMERDKD NPNQYHYVA
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE. (lot specific)
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Molecular Weight
76,821 Da
Sequence Positions
1-759, Full length protein
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
603137
3D Structure
ModBase 3D Structure for Q13619
Species
Human
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of CUL4A recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CUL4A. It may not necessarily be applicable to this product.

NCBI GI #
57165424
NCBI GeneID
8451
NCBI Accession #
NP_001008895.1
UniProt Primary Accession #
Q13619
UniProt Secondary Accession #
O75834; Q589T6; Q5TC62; Q6UP08; Q9UP17; A2A2W2
UniProt Related Accession #
Q13619
GenBank Nucleotide #
NM_001008895.3
NCBI Official Full Name
cullin-4A isoform 1
NCBI Official Synonym Full Names
cullin 4A
NCBI Official Symbol
CUL4A
UniProt Protein Name
Cullin-4A
Protein Family
Cullin
UniProt Gene Name
CUL4A
UniProt Synonym Gene Names
CUL-4A
NCBI Protein Information
cullin-4A

NCBI Summary for CUL4A

CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009 [PubMed 19481525]).[supplied by OMIM, Oct 2009]

UniProt Comments for CUL4A

Core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9. DCX(DTL) directs autoubiquitination of DTL.
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Research Articles on CUL4A

1. Our data demonstrate that overexpression of CUL4A plays an oncogenic role in iCCA and adversely affects disease-free survival. Thus, it may prove to be a powerful prognostic factor and a potential therapeutic target.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CUL4A recombinant protein

 Reference Product  PubMed Publications
 DDB1 recombinant protein  >107 publications with CUL4A and DDB1
 DDB2 recombinant protein  >34 publications with CUL4A and DDB2
 RBX1 recombinant protein  >29 publications with CUL4A and RBX1
 VPRBP recombinant protein  >24 publications with CUL4A and VPRBP
 DTL recombinant protein  >14 publications with CUL4A and DTL
 NEDD8 recombinant protein  >11 publications with CUL4A and NEDD8
 CRBN recombinant protein  >5 publications with CUL4A and CRBN
 CAND1 recombinant protein  >4 publications with CUL4A and CAND1
 FBXW5 recombinant protein  >2 publications with CUL4A and FBXW5

Pathways associated with CUL4A recombinant protein

 Products by Pathway  Pathway Diagram
 Cul4-DDB1-CSA Complex Pathway antibodies  Cul4-DDB1-CSA Complex Pathway Diagram
 Cul4-DDB1-CSA Complex Pathway antibodies  Cul4-DDB1-CSA Complex Pathway Diagram
 Cul4-DDB1-DDB2 Complex Pathway antibodies  Cul4-DDB1-DDB2 Complex Pathway Diagram
 Cul4-DDB1-DDB2 Complex Pathway antibodies  Cul4-DDB1-DDB2 Complex Pathway Diagram
 Nucleotide Excision Repair Pathway antibodies  Nucleotide Excision Repair Pathway Diagram
 Nucleotide Excision Repair Pathway antibodies  Nucleotide Excision Repair Pathway Diagram
 Ubiquitin Mediated Proteolysis Pathway antibodies  Ubiquitin Mediated Proteolysis Pathway Diagram
 Ubiquitin Mediated Proteolysis Pathway antibodies  Ubiquitin Mediated Proteolysis Pathway Diagram

Diseases associated with CUL4A recombinant protein

 Disease Name  Pubmed Publications
 Congenital Abnormalities Antibodies  >8 publications with CUL4A and Congenital Abnormalities
 Neoplasms, Experimental Antibodies  >6 publications with CUL4A and Neoplasms, Experimental
 Nervous System Diseases Antibodies  >6 publications with CUL4A and Nervous System Diseases
 Ataxia Antibodies  >6 publications with CUL4A and Ataxia
 Adenocarcinoma Antibodies  >4 publications with CUL4A and Adenocarcinoma
 Hematologic Diseases Antibodies  >3 publications with CUL4A and Hematologic Diseases
 Neoplasm Metastasis Antibodies  >3 publications with CUL4A and Neoplasm Metastasis
 Neurobehavioral Manifestations Antibodies  >3 publications with CUL4A and Neurobehavioral Manifestations
 Ovarian Neoplasms Antibodies  >3 publications with CUL4A and Ovarian Neoplasms
 Abnormalities, Drug-Induced Antibodies  >2 publications with CUL4A and Abnormalities, Drug-Induced

Organs/Tissues associated with CUL4A recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >16 publications with CUL4A and Blood
 Skin Antibodies  >6 publications with CUL4A and Skin
 Bone Antibodies  >5 publications with CUL4A and Bone
 Lung Antibodies  >5 publications with CUL4A and Lung
 Prostate Antibodies  >4 publications with CUL4A and Prostate
 Liver Antibodies  >3 publications with CUL4A and Liver
 Nerve Antibodies  >3 publications with CUL4A and Nerve
 Bone Marrow Antibodies  >3 publications with CUL4A and Bone Marrow
 Kidney Antibodies  >3 publications with CUL4A and Kidney
 Brain Antibodies  >3 publications with CUL4A and Brain
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