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CXCL4/Pf-4 (CXCL4) Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9149111

Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface… More details

$215 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CXCL4/PF-4, Recombinant Protein
Full Product Name
Recombinant Mouse CXCL4/PF-4 Protein
Product Gene Name
CXCL4 recombinant protein
Product Synonym Names
Pf4, Cxcl4, Scyb4, Platelet factor 4, PF-4, C-X-C motif chemokine 4
Sequence
VTSAGPEESD GDLSCVCVKT ISSGIHLKHI TSLEVIKAGR HCAVPQLIAT LKNGRKICLD RQAPLYKKVI KKILES
Host
HEK293 cells
Form/Format
Lyophilized from 0.22 um filtered solution in PBS (pH7.4). Normally 8% trehalose is added as protectant before lyophilization.
Purity/Purification
PBS
Preparation and Storage
Store at -20 degree C. Store the lyophilized protein at -20 degree C to -80 degree C up to 1 year from the date of receipt.
After reconstitution, the protein solution is stable at -20 degree C for 3 months, at 2-8 degree C for up to 1 week.
3D Structure
ModBase 3D Structure for Q9Z126
Species
Mouse
Tag
C-hFc
Endotoxin
<0.01 EU/ug
Bio-Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CCL5 at 5ug/mL (100 uL/well) can bind Mouse CXCL4 with a linear range of 10-252.6ng/mL.

Product Categories/Family for CXCL4 recombinant protein

Cytokines & Cytokine receptors; Cell Culture related; Proteins
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

SDS-PAGE of CXCL4 recombinant protein

Recombinant Mouse CXCL4/PF-4 Protein 1/FSTL1 Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 40-45kDa.
Mouse CXCL4 Recombinant Protein – Cat# MBS9149111

Testing Data of CXCL4 recombinant protein

The purity of Mouse CXCL4 is greater than 95% as determined by SEC-HPLC.
Mouse CXCL4 Recombinant Protein, Testing Data – Cat# MBS9149111

Other Notes

Small volumes of CXCL4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CXCL4 purchase

MBS9149111 is a recombinant protein targeting CXCL4. Also known as Recombinant Mouse CXCL4/PF-4 Protein. Host: HEK293 cells.

Additional Details

NCBI/Uniprot data below describe general gene information for CXCL4. It may not necessarily be applicable to this product.

NCBI GI #
9910486
NCBI GeneID
56744
NCBI Accession #
NP_064316.1
UniProt Primary Accession #
Q9Z126
UniProt Related Accession #
Q9Z126
GenBank Nucleotide #
NM_019932.4
UniProt Protein Name
Platelet factor 4
UniProt Synonym Protein Names
C-X-C motif chemokine 4
UniProt Gene Name
Pf4
UniProt Synonym Gene Names
Cxcl4; Scyb4; PF-4
UniProt Entry Name
PLF4_MOUSE

UniProt Comments for CXCL4

PF4: Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form. Belongs to the intercrine alpha (chemokine CxC) family.

Protein type: Motility/polarity/chemotaxis; Chemokine; Apoptosis; Secreted, signal peptide; Secreted

Cellular Component: extracellular space; protein complex; extracellular region; vesicle

Molecular Function: heparin binding; CXCR3 chemokine receptor binding; chemokine activity; CXCR chemokine receptor binding; cytokine activity

Biological Process: negative regulation of cytolysis; platelet activation; cytokine and chemokine mediated signaling pathway; leukocyte chemotaxis; positive regulation of leukocyte chemotaxis; response to lipopolysaccharide; positive regulation of cAMP metabolic process; positive regulation of tumor necrosis factor production; chemotaxis; negative regulation of megakaryocyte differentiation; regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; negative regulation of angiogenesis; negative regulation of MHC class II biosynthetic process; immune response; protein complex assembly; positive regulation of transcription from RNA polymerase II promoter; inflammatory response; positive regulation of macrophage differentiation
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with CXCL4 recombinant protein

 Products by Pathway  Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Chemokine Receptors Bind Chemokines Pathway antibodies  Chemokine Receptors Bind Chemokines Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Chemokine Signaling Pathway antibodies  Chemokine Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Common Pathway antibodies  Common Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Formation Of Fibrin Clot (Clotting Cascade) Pathway antibodies  Formation Of Fibrin Clot (Clotting Cascade) Pathway Diagram

Diseases associated with CXCL4 recombinant protein

 Disease Name  Pubmed Publications
 Thrombocytopenia Antibodies  >417 publications with CXCL4 and Thrombocytopenia
 Cardiovascular Diseases Antibodies  >348 publications with CXCL4 and Cardiovascular Diseases
 Thrombosis Antibodies  >286 publications with CXCL4 and Thrombosis
 Heart Diseases Antibodies  >117 publications with CXCL4 and Heart Diseases
 Neoplasms Antibodies  >96 publications with CXCL4 and Neoplasms
 Inflammation Antibodies  >70 publications with CXCL4 and Inflammation
 Autoimmune Diseases Antibodies  >58 publications with CXCL4 and Autoimmune Diseases
 Kidney Diseases Antibodies  >54 publications with CXCL4 and Kidney Diseases
 Lung Diseases Antibodies  >42 publications with CXCL4 and Lung Diseases
 Necrosis Antibodies  >32 publications with CXCL4 and Necrosis

Organs/Tissues associated with CXCL4 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Heart Antibodies  >77 publications with CXCL4 and Heart
 Bone Antibodies  >70 publications with CXCL4 and Bone
 Bone Marrow Antibodies  >61 publications with CXCL4 and Bone Marrow
 Liver Antibodies  >30 publications with CXCL4 and Liver
 Embryonic Tissue Antibodies  >18 publications with CXCL4 and Embryonic Tissue
 Spleen Antibodies  >14 publications with CXCL4 and Spleen
 Joint Antibodies  >8 publications with CXCL4 and Joint
 Thymus Antibodies  >4 publications with CXCL4 and Thymus
 Prostate Antibodies  >4 publications with CXCL4 and Prostate
 Uterus Antibodies  >3 publications with CXCL4 and Uterus
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