EDN3 Recombinant Protein

Name: EDN3 Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS206078
Price: 365 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS206078

EDN3, also known as Endothelin 3, is endothelium-derived vasoconstrictor peptides. Recombinant human EDN3, fused to His-tag at N-terminus, was expressed in E Coli and purified by using conventional chromatography techniques. More details

$365 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

EDN3, Recombinant Protein

Full Product Name

EDN3, 26-238aa, Human, His tag, E Coli

Product Gene Name

EDN3 recombinant protein

Product Synonym Names

Endothelin 3 isform1; ET-3; ET3; HSCR4; PPET3; WS4B

Sequence

MGSSHHHHHH SSGLVPRGSH MGSGDAGRRG VSQAPTAARS EGDCEETVAG PGEETVAGPG EGTVAPTALQ GPSPGSPGQE QAAEGAPEHH RSRRCTCFTY KDKECVYYCH LDIIWINTPE QTVPYGLSNY RGSFRGKRSA GPLPGNLQLS HRPHLRCACV GRYDKACLHF CTQTLDVSSN SRTAEKTDKE EEGKVEVKDQ QSKQALDLHH PKLMPGSGLA LAPSTCPRCL FQEGAP

Host

E Coli

Form/Format

Liquid. In phosphate buffered saline (pH 7.4), 10% glycerol

Purity/Purification

> 85% by SDS-PAGE

Concentration

0.25mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

25.2kDa (236aa) confirmed by MALDI-TOF

OMIM

J05081 mRNA

3D Structure

ModBase 3D Structure for P14138

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for EDN3 recombinant protein

Neuroscience

Applications Tested/Suitable for EDN3 recombinant protein

SDS-PAGE

Product References and Citations for EDN3 recombinant protein

Lee S., et al. (1999) Blood. 94:1440-1450; Bolk S., et al. (1996) Nat. Genet. 13:395-396

Other Notes

Small volumes of EDN3 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EDN3 purchase

MBS206078 is a recombinant protein targeting EDN3. Also known as EDN3, 26-238aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for EDN3. It may not necessarily be applicable to this product.

NCBI GI #

46370064

NCBI GeneID

1908

NCBI Accession #

NP_996917

UniProt Primary Accession #

P14138

UniProt Secondary Accession #

Q03229; Q7Z6D2; Q9UGT7; E1P5I5

UniProt Related Accession #

P14138

GenBank Nucleotide #

NM_207034.2

NCBI Official Full Name

endothelin-3 isoform 1 preproprotein

NCBI Official Synonym Full Names

endothelin 3

NCBI Official Symbol

EDN3

NCBI Official Synonym Symbols

ET3; ET-3; WS4B; HSCR4; PPET3

UniProt Protein Name

Endothelin-3

UniProt Synonym Protein Names

Preproendothelin-3; PPET3

Protein Family

Endothelin

UniProt Gene Name

EDN3

UniProt Synonym Gene Names

ET-3; PPET3

NCBI Protein Information

endothelin-3

NCBI Summary for EDN3

The protein encoded by this gene is a member of the endothelin family. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions. The active form of this protein is a 21 amino acid peptide processed from the precursor protein. The active peptide is a ligand for endothelin receptor type B (EDNRB). The interaction of this endothelin with EDNRB is essential for development of neural crest-derived cell lineages, such as melanocytes and enteric neurons. Mutations in this gene and EDNRB have been associated with Hirschsprung disease (HSCR) and Waardenburg syndrome (WS), which are congenital disorders involving neural crest-derived cells. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]

UniProt Comments for EDN3

Endothelins are endothelium-derived vasoconstrictor peptides.

Research Articles on EDN3

1. the critical physiological role of the KIT-ET3-NO pathway in fulfilling high demand (exceeding basal level) of endothelium-dependent NO generation for coping with atherosclerosis, pregnancy, and aging, is reported.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with EDN3 recombinant protein

Reference Product	PubMed Publications
EDNRB recombinant protein	>108 publications with EDN3 and EDNRB
EDNRA recombinant protein	>11 publications with EDN3 and EDNRA
TAC1 recombinant protein	>1 publications with EDN3 and TAC1

Pathways associated with EDN3 recombinant protein

Products by Pathway	Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Endothelins Pathway antibodies	Endothelins Pathway Diagram
G Alpha (q) Signalling Events Pathway antibodies	G Alpha (q) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram
GPCR Ligand Binding Pathway antibodies	GPCR Ligand Binding Pathway Diagram
Gastrin-CREB Signalling Pathway Via PKC And MAPK antibodies	Gastrin-CREB Signalling Pathway Via PKC And MAPK Diagram
Peptide Ligand-binding Receptors Pathway antibodies	Peptide Ligand-binding Receptors Pathway Diagram
Signal Transduction Pathway antibodies	Signal Transduction Pathway Diagram
Signaling By GPCR Pathway antibodies	Signaling By GPCR Pathway Diagram

Diseases associated with EDN3 recombinant protein

Disease Name	Pubmed Publications
Congenital Abnormalities Antibodies	>91 publications with EDN3 and Congenital Abnormalities
Hirschsprung Disease Antibodies	>81 publications with EDN3 and Hirschsprung Disease
Nervous System Diseases Antibodies	>20 publications with EDN3 and Nervous System Diseases
Disease Models, Animal Antibodies	>14 publications with EDN3 and Disease Models, Animal
Cardiovascular Diseases Antibodies	>7 publications with EDN3 and Cardiovascular Diseases
Waardenburg syndrome, type 4 Antibodies	>6 publications with EDN3 and Waardenburg syndrome, type 4
Vascular Diseases Antibodies	>5 publications with EDN3 and Vascular Diseases
Hypertension Antibodies	>5 publications with EDN3 and Hypertension
Brain Diseases Antibodies	>3 publications with EDN3 and Brain Diseases
Congenital central hypoventilation syndrome Antibodies	>3 publications with EDN3 and Congenital central hypoventilation syndrome

Organs/Tissues associated with EDN3 recombinant protein

Organ/Tissue Name	Pubmed Publications
Nerve Antibodies	>16 publications with EDN3 and Nerve
Intestine Antibodies	>14 publications with EDN3 and Intestine
Muscle Antibodies	>9 publications with EDN3 and Muscle
Eye Antibodies	>6 publications with EDN3 and Eye
Heart Antibodies	>5 publications with EDN3 and Heart
Brain Antibodies	>4 publications with EDN3 and Brain
Ear Antibodies	>3 publications with EDN3 and Ear
Ovary Antibodies	>3 publications with EDN3 and Ovary
Uterus Antibodies	>3 publications with EDN3 and Uterus
Connective Tissue Antibodies	>1 publications with EDN3 and Connective Tissue