FARS2 Recombinant Protein

Name: FARS2 Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS203937
Price: 245 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS203937

Phenylalanyl-tRNA synthetase 2, mitochondrial (PheRS), also known as FARS2, belongs to the class II aminoacyl- tRNA synthetase family. FARS2 is a mitochondrial matrix protein. Functioning as a monomer, FARS2 catalyzes the ATP-dependent conversion of… More details

$245 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

FARS2, Recombinant Protein

Full Product Name

FARS2, 37-451aa, Human, His tag, E Coli

Product Gene Name

FARS2 recombinant protein

Product Synonym Names

Phenylalanyl-tRNA synthetase 2 mitochondrial; Phenylalanyl-tRNA synthetase 2; mitochondrial; dJ520B18.2; FARS1; HSPC320; PheRS

Sequence

MGSSHHHHHH SSGLVPRGSH MPAAECATQR APGSVVELLG KSYPQDDHSN LTRKVLTRVG RNLHNQQHHP LWLIKERVKE HFYKQYVGRF GTPLFSVYDN LSPVVTTWQN FDSLLIPADH PSRKKGDNYY LNRTHMLRAH TSAHQWDLLH AGLDAFLVVG DVYRRDQIDS QHYPIFHQLE AVRLFSKHEL FAGIKDGESL QLFEQSSRSA HKQETHTMEA VKLVEFDLKQ TLTRLMAHLF GDELEIRWVD CYFPFTHPSF EMEINFHGEW LEVLGCGVME QQLVNSAGAQ DRIGWAFGLG LERLAMILYD IPDIRLFWCE DERFLKQFCV SNINQKVKFQ PLSKYPAVIN DISFWLPSEN YAENDFYDLV RTIGGDLVEK VDLIDKFVHP KTHKTSHCYR ITYRHMERTL SQREVRHIHQ ALQEAAVQLL GVEGRF

Host

E Coli

Form/Format

Liquid. In 20mM Tris-HCl Buffer (pH 8.0) containing 1mM DTT, 30% glycerol, 1mM EDTA, 0.1M NaCl

Purity/Purification

> 90% by SDS-PAGE

Concentration

0.5 mg/ml (determined by Bradford assay) (lot specific)

Preparation and Storage

Can be stored at 4 degree C short term (1-2 weeks).
For long term storage, aliquot and store at -20 degree C or -70 degree C.
Avoid repeated freezing and thawing cycles.

Molecular Weight

50.6kDa (436aa), confirmed by MALDI-TOF

OMIM

AF097441 mRNA

3D Structure

ModBase 3D Structure for O95363

Antigen Species

Human

Tag Information

His-tag

Product Categories/Family for FARS2 recombinant protein

Metabolism

Applications Tested/Suitable for FARS2 recombinant protein

SDS-PAGE

Product References and Citations for FARS2 recombinant protein

Sasaki H M., et al. (2006) Proc Natl Acad Sci uSA. 103:14744-14749.; Bullard J M., et al. (1999) J Mol Biol. 288:567-577.

Other Notes

Small volumes of FARS2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FARS2 purchase

MBS203937 is a recombinant protein targeting FARS2. Also known as FARS2, 37-451aa, Human, His tag, E Coli. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for FARS2. It may not necessarily be applicable to this product.

NCBI GI #

5729820

NCBI GeneID

10667

NCBI Accession #

NP_006558

UniProt Primary Accession #

O95363

UniProt Secondary Accession #

Q53F66; Q5TCS3; Q6FG29; Q9NPY7; Q9P062; B2R664

UniProt Related Accession #

O95363

GenBank Nucleotide #

NM_006567.4

NCBI Official Full Name

phenylalanine--tRNA ligase, mitochondrial

NCBI Official Synonym Full Names

phenylalanyl-tRNA synthetase 2, mitochondrial

NCBI Official Symbol

FARS2

NCBI Official Synonym Symbols

FARS1; PheRS; SPG77; COXPD14; HSPC320

UniProt Protein Name

Phenylalanine--tRNA ligase, mitochondrial

UniProt Synonym Protein Names

Phenylalanyl-tRNA synthetase; PheRS

UniProt Gene Name

FARS2

UniProt Synonym Gene Names

FARS1; PheRS

NCBI Protein Information

phenylalanine--tRNA ligase, mitochondrial

NCBI Summary for FARS2

This gene encodes a protein that transfers phenylalanine to its cognate tRNA. This protein localizes to the mitochondrion and plays a role in mitochondrial protein translation. Mutations in this gene can cause combined oxidative phosphorylation deficiency 14 (Alpers encephalopathy). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

UniProt Comments for FARS2

Is responsible for the charging of tRNA(Phe) with phenylalanine in mitochondrial translation. To a lesser extent, also catalyzes direct attachment of m-Tyr (an oxidized version of Phe) to tRNA(Phe), thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins.

Research Articles on FARS2

1. in patients with drug-resistant infantile spasm syndrome, associated with focal seizures, mild metabolic changes, and cerebral atrophy with volume loss of white matter on MRI, mutations in FARS2 should be considered.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with FARS2 recombinant protein

Products by Pathway	Pathway Diagram
Aminoacyl-tRNA Biosynthesis Pathway antibodies	Aminoacyl-tRNA Biosynthesis Pathway Diagram
Aminoacyl-tRNA Biosynthesis Pathway antibodies	Aminoacyl-tRNA Biosynthesis Pathway Diagram
Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway antibodies	Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway Diagram
Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway antibodies	Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Mitochondrial TRNA Aminoacylation Pathway antibodies	Mitochondrial TRNA Aminoacylation Pathway Diagram
TRNA Aminoacylation Pathway antibodies	TRNA Aminoacylation Pathway Diagram

Diseases associated with FARS2 recombinant protein

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>10 publications with FARS2 and Nervous System Diseases
Seizures Antibodies	>2 publications with FARS2 and Seizures
COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 14 Antibodies	>2 publications with FARS2 and COMBINED OXIDATIVE PHOSPHORYLATION DEFICIENCY 14
Anemia Antibodies	>1 publications with FARS2 and Anemia
Memory Disorders Antibodies	>1 publications with FARS2 and Memory Disorders

Organs/Tissues associated with FARS2 recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>7 publications with FARS2 and Brain
Skin Antibodies	>1 publications with FARS2 and Skin
Blood Antibodies	>1 publications with FARS2 and Blood