Human FGF21 Recombinant Protein – Cat# MBS2584500

SDS-PAGE analysis of Human FGF21 proteins, 2 μg/lane of Recombinant Human FGF21 proteins was resolved with SDS-PAGE under reducing conditions, showing bands at 37 kDa.

FGF21 Human Recombinant Protein

Name: FGF21 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS2584500
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2584500

Fibroblast growth factor 21 (FGF21) is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell… More details

$235 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

FGF21, Recombinant Protein

Full Product Name

Recombinant Human FGF21 Protein (His Tag)

Product Gene Name

FGF21 recombinant protein

Product Synonym Names

FGF-21; Fibroblast growth factor 21; PRO10196; UNQ3115

Host

E Coli

Form/Format

Lyophilized from a 0.2 mum filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Purity/Purification

> 95% as determined by reducing SDS-PAGE.

Preparation and Storage

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Molecular Weight

22,300 Da

Sequence Positions

His29-Ser209

Chromosome Location

Chromosome: 19; NC_000019.9 (49259344..49261582). Location: 19q13.33

OMIM

609436

3D Structure

ModBase 3D Structure for Q9NSA1

Species

Human

Endotoxin

< 10 EU/mg of the protein as determined by the LAL method

Protein Tag

N-Trx

Calculated Molecular Weight

39.9 kDa

Observed Molecular Weight

37 kDa

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5 mg/mL. Concentration is measured by UV-Vis

Product Categories/Family for FGF21 recombinant protein

Recombinant Proteins; Others; Metabolism; Cardiovascular; Developmental Biology

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of FGF21 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for FGF21 purchase

MBS2584500 is a recombinant protein targeting FGF21. Also known as Recombinant Human FGF21 Protein (His Tag). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for FGF21. It may not necessarily be applicable to this product.

NCBI GI #

9506597

NCBI GeneID

26291

NCBI Accession #

NP_061986.1

UniProt Primary Accession #

Q9NSA1

UniProt Secondary Accession #

Q8N683

UniProt Related Accession #

Q9NSA1

GenBank Nucleotide #

NM_019113.2

NCBI Official Full Name

fibroblast growth factor 21

NCBI Official Synonym Full Names

fibroblast growth factor 21

NCBI Official Symbol

FGF21

UniProt Protein Name

Fibroblast growth factor 21

Protein Family

Fibroblast growth factor

UniProt Gene Name

FGF21

UniProt Synonym Gene Names

FGF-21

UniProt Entry Name

FGF21_HUMAN

NCBI Protein Information

fibroblast growth factor 21; FGF-21

NCBI Summary for FGF21

The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. The function of this growth factor has not yet been determined. [provided by RefSeq, Jul 2008]

UniProt Comments for FGF21

FGF21: Stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Activity requires the presence of KLB. Belongs to the heparin-binding growth factors family.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 19q13.33

Cellular Component: extracellular region

Molecular Function: protein binding; growth factor activity; fibroblast growth factor receptor binding

Biological Process: positive regulation of glucose import; cell-cell signaling; positive regulation of cell proliferation; positive regulation of low-density lipoprotein receptor biosynthetic process; signal transduction

Research Articles on FGF21

1. The results suggest that FGF-21 is related to BMI but not disease activity or lipid profiles in patients with RA.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FGF21 recombinant protein

Reference Product	PubMed Publications
PPARG recombinant protein	>27 publications with FGF21 and PPARG
FGFR1 recombinant protein	>24 publications with FGF21 and FGFR1
KLB recombinant protein	>21 publications with FGF21 and KLB
FGFR4 recombinant protein	>13 publications with FGF21 and FGFR4
FGFR2 recombinant protein	>7 publications with FGF21 and FGFR2
AKT1 recombinant protein	>4 publications with FGF21 and AKT1
FGFR3 recombinant protein	>4 publications with FGF21 and FGFR3
CYP7A1 recombinant protein	>3 publications with FGF21 and CYP7A1
INS recombinant protein	>1 publications with FGF21 and INS

Pathways associated with FGF21 recombinant protein

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Pathways In Cancer antibodies	Pathways In Cancer Diagram
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Regulation Of Actin Cytoskeleton Pathway antibodies	Regulation Of Actin Cytoskeleton Pathway Diagram

Diseases associated with FGF21 recombinant protein

Disease Name	Pubmed Publications
Insulin Resistance Antibodies	>97 publications with FGF21 and Insulin Resistance
Fatty Liver Antibodies	>92 publications with FGF21 and Fatty Liver
Diabetes Mellitus, Type 2 Antibodies	>51 publications with FGF21 and Diabetes Mellitus, Type 2
Liver Diseases Antibodies	>51 publications with FGF21 and Liver Diseases
Inflammation Antibodies	>25 publications with FGF21 and Inflammation
Hyperglycemia Antibodies	>25 publications with FGF21 and Hyperglycemia
Weight Loss Antibodies	>25 publications with FGF21 and Weight Loss
Cardiovascular Diseases Antibodies	>19 publications with FGF21 and Cardiovascular Diseases
Non-alcoholic Fatty Liver Disease Antibodies	>19 publications with FGF21 and Non-alcoholic Fatty Liver Disease
Kidney Diseases Antibodies	>15 publications with FGF21 and Kidney Diseases

Organs/Tissues associated with FGF21 recombinant protein

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>1 publications with FGF21 and Lung