Human FKB1B Recombinant Protein – Cat# MBS7617232

FKB1B Human Recombinant Protein

Name: FKB1B Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS7617232
Price: 535 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS7617232

MBS7617232 is a recombinant protein targeting FKB1B. Also known as Recombinant Human FKB1B. Host: E coli. More details

$535 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

FKB1B, Recombinant Protein

Full Product Name

Recombinant Human FKB1B

Product Gene Name

FKB1B recombinant protein

Product Synonym Names

12.6 kDa FK506-binding protein; 12.6 kDa FKBP; Calstabin 2; FK506 binding protein 1 like; FK506 binding protein 12.6; FK506 binding protein 1B; FK506 binding protein 1B 12.6 kDa; FK506-binding protein 1B; FKB1B_HUMAN; FKBP 12.6; FKBP 1B; FKBP 1L; FKBP 9; FKBP-12.6; FKBP-1B; FKBP12.6

Host

E coli

Form/Format

Lyophilized from a 0.2 um filtered solution in 10 mM Hepes, 500 mM NaCl with 5% trehalose, pH7.4

Purity/Purification

Greater than 90% as determined by SDS-PAGE

Preparation and Storage

The lyophilized protein is stable at -20 degree C for up to 1 year, the protein solution can be stored at 2-8 degree C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing 0.1% BSA (make sure BSA will NOT interfere with your experiment) and store in working aliquots at -20 degree C to -80 degree C for 6 months. Avoid repeated freeze/thaw cycle.

Molecular Weight

8,802 Da

Sequence Positions

1-108

OMIM

600620

3D Structure

ModBase 3D Structure for P68106

Species

Human

Tag

N-terminal His-IF2DI

Reconstitution

Centrifuge the vial prior to opening, reconstitute in sterile distilled water or buffer of interest to concentration of 0.1-1mg/ml by gently pipetting 2-3 times, don't vortex

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Applications Tested/Suitable for FKB1B recombinant protein

Western Blot (WB), ELISA (EIA)

Other Notes

Small volumes of FKB1B recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FKB1B. It may not necessarily be applicable to this product.

NCBI GI #

4758380

NCBI GeneID

2281

NCBI Accession #

NP_004107.1

UniProt Primary Accession #

P68106

UniProt Secondary Accession #

Q13664; Q16645; Q53TM2; Q9BQ40

UniProt Related Accession #

P68106

GenBank Nucleotide #

NM_004116.3

NCBI Official Full Name

peptidyl-prolyl cis-trans isomerase FKBP1B isoform a

NCBI Official Synonym Full Names

FK506 binding protein 1B, 12.6 kDa

NCBI Official Symbol

FKBP1B

NCBI Official Synonym Symbols

OTK4; FKBP1L; PKBP1L; PPIase; FKBP12.6

UniProt Protein Name

Peptidyl-prolyl cis-trans isomerase FKBP1B

UniProt Synonym Protein Names

12.6 kDa FK506-binding protein; 12.6 kDa FKBP; FKBP-12.6; FK506-binding protein 1B; FKBP-1B; Immunophilin FKBP12.6; Rotamase; h-FKBP-12

UniProt Gene Name

FKBP1B

UniProt Synonym Gene Names

FKBP12.6; FKBP1L; FKBP9; OTK4; PPIase FKBP1B; 12.6 kDa FKBP; FKBP-12.6; FKBP-1B

UniProt Entry Name

FKB1B_HUMAN

NCBI Protein Information

peptidyl-prolyl cis-trans isomerase FKBP1B; 12.6 kDa FK506-binding protein; 12.6 kDa FKBP; FK506-binding protein 12.6; FK506-binding protein 1B; FKBP-12.6; FKBP-1B; PPIase FKBP1B; calstabin 2; h-FKBP-12; immunophilin FKBP12.6; rotamase

NCBI Summary for FKB1B

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds the immunosuppressants FK506 and rapamycin. It is highly similar to the FK506-binding protein 1A. Its physiological role is thought to be in excitation-contraction coupling in cardiac muscle. There are two alternatively spliced transcript variants of this gene encoding different isoforms. [provided by RefSeq, Jul 2008]

UniProt Comments for FKB1B

FKBP1B: Has the potential to contribute to the immunosuppressive and toxic effects of FK506 and rapamycin. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Belongs to the FKBP-type PPIase family. FKBP1 subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Isomerase; EC 5.2.1.8

Chromosomal Location of Human Ortholog: 2p23.3

Cellular Component: sarcoplasmic reticulum membrane; membrane; cytoplasm; Z disc; cytosol

Molecular Function: protein binding; peptidyl-prolyl cis-trans isomerase activity; FK506 binding; cyclic nucleotide binding; calcium channel inhibitor activity; ryanodine-sensitive calcium-release channel activity; receptor binding

Biological Process: positive regulation of sequestering of calcium ion; positive regulation of axon regeneration; protein maturation via protein folding; protein peptidyl-prolyl isomerization; cytosolic calcium ion homeostasis; negative regulation of heart rate; response to redox state; release of sequestered calcium ion by sarcoplasmic reticulum into cytosol; T cell proliferation; negative regulation of protein phosphatase type 2B activity; response to vitamin E; smooth muscle contraction; 'de novo' protein folding; response to hydrogen peroxide; insulin secretion; negative regulation of release of sequestered calcium ion into cytosol; action potential propagation; response to glucose stimulus; protein refolding; transmembrane transport

Research Articles on FKB1B

1. Sirolimus-FKBP12.6 impairs endothelial barrier function by activation of protein kinase C-alpha and downstream disruption of the p120-VE cadherin interaction in vascular endothelium.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with FKB1B recombinant protein

Reference Product	PubMed Publications
RYR2 recombinant protein	>5 publications with FKB1B and RYR2

Pathways associated with FKB1B recombinant protein

Products by Pathway	Pathway Diagram
Integrated Pancreatic Cancer Pathway antibodies	Integrated Pancreatic Cancer Pathway Diagram
Ion Channel Transport Pathway antibodies	Ion Channel Transport Pathway Diagram
Stimuli-sensing Channels Pathway antibodies	Stimuli-sensing Channels Pathway Diagram
Transmembrane Transport Of Small Molecules Pathway antibodies	Transmembrane Transport Of Small Molecules Pathway Diagram

Diseases associated with FKB1B recombinant protein

Disease Name	Pubmed Publications
Tachycardia, Ventricular Antibodies	>2 publications with FKB1B and Tachycardia, Ventricular
Ventricular Fibrillation Antibodies	>1 publications with FKB1B and Ventricular Fibrillation
Atrial Fibrillation Antibodies	>1 publications with FKB1B and Atrial Fibrillation
Cardiomyopathies Antibodies	>1 publications with FKB1B and Cardiomyopathies
Arrhythmias, Cardiac Antibodies	>1 publications with FKB1B and Arrhythmias, Cardiac
Hypertension Antibodies	>1 publications with FKB1B and Hypertension
Heart Failure Antibodies	>1 publications with FKB1B and Heart Failure
Hyperplasia Antibodies	>1 publications with FKB1B and Hyperplasia
Disease Models, Animal Antibodies	>1 publications with FKB1B and Disease Models, Animal

Organs/Tissues associated with FKB1B recombinant protein

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>2 publications with FKB1B and Muscle
Brain Antibodies	>2 publications with FKB1B and Brain
Blood Antibodies	>1 publications with FKB1B and Blood
Eye Antibodies	>1 publications with FKB1B and Eye