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FKBP5 Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS1578177

MBS1578177 is a recombinant protein targeting FKBP5. Also known as Recombinant Human FKBP5 Protein, N-His. Host: E coli. More details

$435 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
FKBP5, Recombinant Protein
Full Product Name
Recombinant Human FKBP5 Protein, N-His
Product Gene Name
Product Synonym Names
AIG6; 51 kDa FKBP; FKBP51; FKBP54; Rotamase; Peptidyl-prolyl cis-trans isomerase FKBP5; FF1 antigen; 51 kDa FK506-binding protein; FKBP-51; Androgen-regulated protein 6; p54; PPIase FKBP5; 54 kDa progesterone receptor-associated immunophilin; HSP90-binding immunophilin; FKBP-5; FK506-binding protein 5; FKBP5
Host
E coli
Form/Format
Lyophilized from a solution in PBS pH7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Purity/Purification
>90% as determined by SDS-PAGE
Preparation and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 degree C for one week. Store at -20 degree C for twelve months from the date of receipt.
Molecular Weight
457
Sequence Positions
Ser13-Lys252
OMIM
602623
3D Structure
ModBase 3D Structure for Q13451
Species
Human
Reconstitution
Reconstitute in sterile water for a stock solution.

Product Categories/Family for FKBP5 recombinant protein

ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for FKBP5 recombinant protein
SDS-PAGE (SDS), Western Blot (WB), ELISA (EIA), Immunogen

SDS-Page of FKBP5 recombinant protein

SDS PAGE for Recombinant Human FKBP5 protein
Human FKBP5 Recombinant Protein – Cat# MBS1578177

Other Notes

Small volumes of FKBP5 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FKBP5. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
Peptidyl-prolyl cis-trans isomerase FKBP5
NCBI Official Synonym Full Names
FK506 binding protein 5
NCBI Official Symbol
FKBP5
NCBI Official Synonym Symbols
P54; AIG6; FKBP51; FKBP54; PPIase; Ptg-10
UniProt Protein Name
Peptidyl-prolyl cis-trans isomerase FKBP5
UniProt Synonym Protein Names
51 kDa FK506-binding protein; 51 kDa FKBP; FKBP-51; 54 kDa progesterone receptor-associated immunophilin; Androgen-regulated protein 6; FF1 antigen; FK506-binding protein 5; FKBP-5; FKBP54; p54; HSP90-binding immunophilin; Rotamase
Protein Family
UniProt Gene Name
FKBP5
UniProt Synonym Gene Names
AIG6; FKBP51; PPIase FKBP5; 51 kDa FKBP; FKBP-51; FKBP-5; p54
UniProt Entry Name
FKBP5_HUMAN
NCBI Protein Information
peptidyl-prolyl cis-trans isomerase FKBP5; FKBP-51; rotamase; 51 kDa FKBP; FF1 antigen; PPIase FKBP5; HSP90-binding immunophilin; 51 kDa FK506-binding protein; T-cell FK506-binding protein; androgen-regulated protein 6; peptidylprolyl cis-trans isomerase;

NCBI Summary for FKBP5

The protein encoded by this gene is a member of the immunophilin protein family, which play a role in immunoregulation and basic cellular processes involving protein folding and trafficking. This encoded protein is a cis-trans prolyl isomerase that binds to the immunosuppressants FK506 and rapamycin. It is thought to mediate calcineurin inhibition. It also interacts functionally with mature hetero-oligomeric progesterone receptor complexes along with the 90 kDa heat shock protein and P23 protein. This gene has been found to have multiple polyadenylation sites. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
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UniProt Comments for FKBP5

FKBP5: Interacts with functionally mature heterooligomeric progesterone receptor complexes along with HSP90 and TEBP. Part of a heteromultimeric cytoplasmic complex with HSP90, HSP70 and steroid receptors. Dissociates from the complex when NR3C1 binds glucocorticoid. By androgen. Widely expressed, enriched in testis compared to other tissues. Inhibited by FK506 but not cyclosporin.

Protein type: EC 5.2.1.8; Isomerase; Chaperone

Chromosomal Location of Human Ortholog: 6p21.31

Cellular Component: nucleoplasm; endoplasmic reticulum membrane; membrane

Molecular Function: protein binding; peptidyl-prolyl cis-trans isomerase activity; FK506 binding; heat shock protein binding

Biological Process: protein peptidyl-prolyl isomerization; protein folding

Disease: Major Depressive Disorder
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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