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GRPR Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS189461

Recombinant Human GRPR Protein with C-terminal human Fc tagGastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and… More details

$280 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GRPR, Recombinant Protein
Full Product Name
Human GRPR Protein, hFc Tag
Product Gene Name
GRPR recombinant protein
Product Synonym Names
BB2; BB2R; BRS2
Sequence
GRPR(Met1- Gly38) hFc(Glu99- Ala330)
Host
HEK293
Form/Format
Lyophilized from sterile PBS, pH 7.4. Normally 5%-8% trehalose is added as protectants before lyophilization.
Purity/Purification
Purified from cell culture supernatant by affinity chromatography
The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Preparation and Storage
Store at -20 degree C to -80 degree C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80 degree C (Avoid repeated freezing and thawing).
Molecular Weight
384
OMIM
305670
3D Structure
ModBase 3D Structure for P30550
Tag
C-Human Fc Tag

Product Categories/Family for GRPR recombinant protein

ECD 1182; ECD Proteins

SDS-Page of GRPR recombinant protein

Figure 1.Human GRPR Protein, hFc Tag on SDS-PAGE under reducing condition.
Human GRPR Recombinant Protein – Cat# MBS189461

Other Notes

Small volumes of GRPR recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GRPR purchase

MBS189461 is a recombinant protein targeting GRPR. Also known as Human GRPR Protein, hFc Tag. Host: HEK293.

Additional Details

NCBI/Uniprot data below describe general gene information for GRPR. It may not necessarily be applicable to this product.

NCBI GI #
232185
NCBI GeneID
2925
NCBI Accession #
P30550.1
UniProt Primary Accession #
P30550
UniProt Secondary Accession #
B2R910
UniProt Related Accession #
P30550; AAB27329
NCBI Official Full Name
Gastrin-releasing peptide receptor
NCBI Official Synonym Full Names
gastrin-releasing peptide receptor
NCBI Official Symbol
GRPR
NCBI Official Synonym Symbols
BB2
UniProt Protein Name
Gastrin-releasing peptide receptor
UniProt Synonym Protein Names
GRP-preferring bombesin receptor
Protein Family
Gastrin-releasing peptide receptor
UniProt Gene Name
GRPR
UniProt Synonym Gene Names
GRP-R
UniProt Entry Name
GRPR_HUMAN
NCBI Protein Information
gastrin-releasing peptide receptor; GRP-R; bombesin receptor 2; GRP-preferring bombesin receptor

NCBI Summary for GRPR

Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for GRPR

GRPR: Receptor for gastrin releasing peptide (GRP). This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: Xp22.2

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: bombesin receptor activity; peptide receptor activity, G-protein coupled

Biological Process: G-protein coupled receptor protein signaling pathway; cell proliferation; bombesin receptor signaling pathway; regulation of cell proliferation
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Research Articles on GRPR

1. a key mechanism for GRPR-regulated colon cancer cell migration through the Galpha13-PRG-RhoA-ROCK pathway.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with GRPR recombinant protein

 Reference Product  PubMed Publications
 GRP recombinant protein  >138 publications with GRPR and GRP
 CCK recombinant protein  >2 publications with GRPR and CCK

Pathways associated with GRPR recombinant protein

 Products by Pathway  Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 GPCRs, Other Pathway antibodies  GPCRs, Other Pathway Diagram

Diseases associated with GRPR recombinant protein

 Disease Name  Pubmed Publications
 Prostatic Neoplasms Antibodies  >69 publications with GRPR and Prostatic Neoplasms
 Lung Neoplasms Antibodies  >22 publications with GRPR and Lung Neoplasms
 Breast Neoplasms Antibodies  >19 publications with GRPR and Breast Neoplasms
 Lung Diseases Antibodies  >16 publications with GRPR and Lung Diseases
 Pain Antibodies  >16 publications with GRPR and Pain
 Inflammation Antibodies  >15 publications with GRPR and Inflammation
 Disease Models, Animal Antibodies  >14 publications with GRPR and Disease Models, Animal
 Memory Disorders Antibodies  >9 publications with GRPR and Memory Disorders
 Brain Diseases Antibodies  >8 publications with GRPR and Brain Diseases
 Hyperplasia Antibodies  >7 publications with GRPR and Hyperplasia

Organs/Tissues associated with GRPR recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >52 publications with GRPR and Brain
 Intestine Antibodies  >4 publications with GRPR and Intestine
 Embryonic Tissue Antibodies  >2 publications with GRPR and Embryonic Tissue
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