Human GSPT2 Recombinant Protein – Cat# MBS7616035

GSPT2 Human Recombinant Protein

Name: GSPT2 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS7616035
Price: 430 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS7616035

MBS7616035 is a recombinant protein targeting GSPT2. Also known as Recombinant Human GSPT2. Host: E Coli. More details

$430 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GSPT2, Recombinant Protein

Full Product Name

Recombinant Human GSPT2

Product Gene Name

GSPT2 recombinant protein

Product Synonym Names

eRF3b; G1 to S phase transition 2; GSPT2; GST2

Host

E Coli

Form/Format

Lyophilized from a 0.2 um filtered solution in 10 mM Hepes, 500 mM NaCl with 5% trehalose and 0.06% proclin, pH7.4

Purity/Purification

Greater than 90% by SDS-PAGE gel analyses

Preparation and Storage

Store at -20 degree C for 12 months as lyophilized; 2-8 degree C for 1 month under sterile conditions after reconstitution

Molecular Weight

68,883 Da

Sequence Positions

1-204

OMIM

300418

3D Structure

ModBase 3D Structure for Q8IYD1

Species

Human

Tag

N-terminal His Tag

Reconstitution

Centrifuge the vial at 10,000 rpm for 1 minute, reconstitute at 200 ug/ml in sterile distilled water by gentle pipetting 2-3 times, don't vortex

ISO Certification

Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.

Applications Tested/Suitable for GSPT2 recombinant protein

Western Blot (WB), ELISA (EIA)

Other Notes

Small volumes of GSPT2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GSPT2. It may not necessarily be applicable to this product.

NCBI GI #

46094014

NCBI GeneID

23708

NCBI Accession #

NP_060564

UniProt Primary Accession #

Q8IYD1

UniProt Secondary Accession #

Q9H909; Q9NVY0; Q9NY44

UniProt Related Accession #

Q8IYD1

GenBank Nucleotide #

NM_018094.4

NCBI Official Full Name

eukaryotic peptide chain release factor GTP-binding subunit ERF3B

NCBI Official Synonym Full Names

G1 to S phase transition 2

NCBI Official Symbol

GSPT2

NCBI Official Synonym Symbols

GST2; ERF3B

UniProt Protein Name

Eukaryotic peptide chain release factor GTP-binding subunit ERF3B

UniProt Synonym Protein Names

G1 to S phase transition protein 2 homolog

Protein Family

Eukaryotic peptide chain release factor GTP-binding

UniProt Gene Name

GSPT2

UniProt Synonym Gene Names

ERF3B; Eukaryotic peptide chain release factor subunit 3b; eRF3b

UniProt Entry Name

ERF3B_HUMAN

NCBI Protein Information

eukaryotic peptide chain release factor GTP-binding subunit ERF3B

NCBI Summary for GSPT2

This gene encodes a GTPase that belongs to the GTP-binding elongation factor family. The encoded protein is a polypeptide release factor that complexes with eukaryotic peptide chain release factor 1 to mediate translation termination. This protein may also be involved in mRNA stability.[provided by RefSeq, Mar 2010]

UniProt Comments for GSPT2

GSPT2: Involved in translation termination in response to the termination codons UAA, UAG and UGA. May play a role as a potent stimulator of the release factor activity of ETF1. Exhibits GTPase activity, which is ribosome- and ETF1-dependent. May play a role in cell cycle progression. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Belongs to the GTP-binding elongation factor family. ERF3 subfamily.

Protein type: Hydrolase; RNA-binding; Translation

Chromosomal Location of Human Ortholog: Xp11.22

Cellular Component: cytosol

Molecular Function: GTPase activity; protein binding; GTP binding

Biological Process: cellular protein metabolic process; translation; mRNA catabolic process, nonsense-mediated decay; gene expression; translational termination; cell cycle

Research Articles on GSPT2

1. The tumor marker eRF3B can change the cell cycle and influence the phosphorylation status of 4E-BP1.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with GSPT2 recombinant protein

Products by Pathway	Pathway Diagram
Eukaryotic Translation Termination Pathway antibodies	Eukaryotic Translation Termination Pathway Diagram
Gene Expression Pathway antibodies	Gene Expression Pathway Diagram
Metabolism Of Proteins Pathway antibodies	Metabolism Of Proteins Pathway Diagram
Nonsense Mediated Decay (NMD) Enhanced By The Exon Junction Complex (EJC) Pathway antibodies	Nonsense Mediated Decay (NMD) Enhanced By The Exon Junction Complex (EJC) Pathway Diagram
Nonsense Mediated Decay (NMD) Independent Of The Exon Junction Complex (EJC) Pathway antibodies	Nonsense Mediated Decay (NMD) Independent Of The Exon Junction Complex (EJC) Pathway Diagram
Nonsense-Mediated Decay (NMD) Pathway antibodies	Nonsense-Mediated Decay (NMD) Pathway Diagram
Translation Pathway antibodies	Translation Pathway Diagram
Translation Factors Pathway antibodies	Translation Factors Pathway Diagram
MRNA Surveillance Pathway antibodies	MRNA Surveillance Pathway Diagram
MRNA Surveillance Pathway antibodies	MRNA Surveillance Pathway Diagram

Diseases associated with GSPT2 recombinant protein

Disease Name	Pubmed Publications
Neurobehavioral Manifestations Antibodies	>1 publications with GSPT2 and Neurobehavioral Manifestations
Liver Diseases Antibodies	>1 publications with GSPT2 and Liver Diseases
Hepatitis Antibodies	>1 publications with GSPT2 and Hepatitis
Liver Neoplasms Antibodies	>1 publications with GSPT2 and Liver Neoplasms
Adenocarcinoma Antibodies	>1 publications with GSPT2 and Adenocarcinoma
Carcinoma, Hepatocellular Antibodies	>1 publications with GSPT2 and Carcinoma, Hepatocellular

Organs/Tissues associated with GSPT2 recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>2 publications with GSPT2 and Brain
Mammary Gland Antibodies	>1 publications with GSPT2 and Mammary Gland
Thyroid Antibodies	>1 publications with GSPT2 and Thyroid
Prostate Antibodies	>1 publications with GSPT2 and Prostate
Blood Antibodies	>1 publications with GSPT2 and Blood
Liver Antibodies	>1 publications with GSPT2 and Liver