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HBEGF Mouse Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS189227

Recombinant mouse HBEGF (24-160) protein with C-terminal 6×His tagGrowth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be… More details

$280 / 0.01 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
HBEGF, Recombinant Protein
Full Product Name
Mouse HBEGF (24-160) Protein, His Tag
Product Gene Name
HBEGF recombinant protein
Product Synonym Names
AW047313; Dtr; Dts; Hegfl
Host
HEK293
Form/Format
Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose is added as protectants before lyophilization. Please see Certificate of Analysis for specific instructions.
Purity/Purification
The purity of the protein is greater than 85% as determined by SDS-PAGE and Coomassie blue staining.
Preparation and Storage
Store at -20 degree C to -80 degree C for 12 months in lyophilized form. After reconstitution, if not intended for use within a month, aliquot and store at -80 degree C (Avoid repeated freezing and thawing). Lyophilized proteins are shipped at ambient temperature.
Molecular Weight
22,808 Da
3D Structure
ModBase 3D Structure for Q06186
Tag
C-6×His tag

Product Categories/Family for HBEGF recombinant protein

Bioactive Protein

SDS-Page of HBEGF recombinant protein

Figure 1. Mouse HBEGF (24-160) Protein, His Tag on SDS-PAGE under reducing condition.
Mouse HBEGF Recombinant Protein – Cat# MBS189227

Other Notes

Small volumes of HBEGF recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HBEGF purchase

MBS189227 is a recombinant protein targeting HBEGF. Also known as Mouse HBEGF (24-160) Protein, His Tag. Host: HEK293.

Additional Details

NCBI/Uniprot data below describe general gene information for HBEGF. It may not necessarily be applicable to this product.

NCBI GI #
6754178
NCBI GeneID
15200
NCBI Accession #
NP_034545.1
UniProt Primary Accession #
Q06186
UniProt Related Accession #
Q06186
GenBank Nucleotide #
NM_010415.2
NCBI Official Full Name
proheparin-binding EGF-like growth factor
NCBI Official Synonym Full Names
heparin-binding EGF-like growth factor
NCBI Official Symbol
Hbegf
NCBI Official Synonym Symbols
Dtr; Dts; Hegfl; AW047313
UniProt Protein Name
Proheparin-binding EGF-like growth factor
Protein Family
Proheparin-binding EGF-like growth factor
UniProt Gene Name
Hbegf
UniProt Synonym Gene Names
Dtr; Hegfl; HB-EGF; HBEGF
UniProt Entry Name
HBEGF_MOUSE
NCBI Protein Information
proheparin-binding EGF-like growth factor; diphtheria toxin receptor; heparin binding epidermal growth factor-like growth factor

UniProt Comments for HBEGF

HBEGF: Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.

Protein type: Cell surface; Membrane protein, integral

Cellular Component: extracellular space; cell surface; membrane; integral to plasma membrane; extracellular region; plasma membrane; integral to membrane

Molecular Function: heparin binding; growth factor activity; epidermal growth factor receptor binding

Biological Process: positive regulation of keratinocyte migration; epidermal growth factor receptor signaling pathway; positive regulation of protein kinase B signaling cascade; cell migration; positive regulation of smooth muscle cell proliferation; negative regulation of elastin biosynthetic process; angiogenesis; blastocyst growth; positive regulation of cell growth; regulation of heart contraction; positive regulation of cell migration; wound healing, spreading of epidermal cells
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Research Articles on HBEGF

1. miR-96 promotes osteogenic differentiation by inhibiting HB-EGF and by blocking the HB-EGF-EGFR signaling pathway in osteoblastic cells

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with HBEGF recombinant protein

 Reference Product  PubMed Publications
 Egfr recombinant protein  >339 publications with HBEGF and Egfr
 Erbb4 recombinant protein  >66 publications with HBEGF and Erbb4
 Adam17 recombinant protein  >39 publications with HBEGF and Adam17
 Erbb3 recombinant protein  >21 publications with HBEGF and Erbb3
 Nrg1 recombinant protein  >9 publications with HBEGF and Nrg1
 Nrg2 recombinant protein  >6 publications with HBEGF and Nrg2
 Grb2 recombinant protein  >4 publications with HBEGF and Grb2

Pathways associated with HBEGF recombinant protein

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Constitutive PI3K/AKT Signaling In Cancer Pathway antibodies  Constitutive PI3K/AKT Signaling In Cancer Pathway Diagram
 DAP12 Interactions Pathway antibodies  DAP12 Interactions Pathway Diagram
 DAP12 Signaling Pathway antibodies  DAP12 Signaling Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Downstream Signal Transduction Pathway antibodies  Downstream Signal Transduction Pathway Diagram
 Downstream Signaling Events Of B Cell Receptor (BCR) Pathway antibodies  Downstream Signaling Events Of B Cell Receptor (BCR) Pathway Diagram
 Downstream Signaling Of Activated FGFR Pathway antibodies  Downstream Signaling Of Activated FGFR Pathway Diagram
 EGFR Transactivation By Gastrin Pathway antibodies  EGFR Transactivation By Gastrin Pathway Diagram
 ErbB Signaling Pathway antibodies  ErbB Signaling Pathway Diagram

Diseases associated with HBEGF recombinant protein

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >133 publications with HBEGF and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >114 publications with HBEGF and Disease Models, Animal
 Necrosis Antibodies  >112 publications with HBEGF and Necrosis
 Inflammation Antibodies  >79 publications with HBEGF and Inflammation
 Lung Diseases Antibodies  >49 publications with HBEGF and Lung Diseases
 Heart Diseases Antibodies  >48 publications with HBEGF and Heart Diseases
 Hyperplasia Antibodies  >47 publications with HBEGF and Hyperplasia
 Reperfusion Injury Antibodies  >42 publications with HBEGF and Reperfusion Injury
 Liver Diseases Antibodies  >40 publications with HBEGF and Liver Diseases
 Hypertrophy Antibodies  >39 publications with HBEGF and Hypertrophy

Organs/Tissues associated with HBEGF recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >204 publications with HBEGF and Muscle
 Skin Antibodies  >99 publications with HBEGF and Skin
 Brain Antibodies  >85 publications with HBEGF and Brain
 Lung Antibodies  >85 publications with HBEGF and Lung
 Intestine Antibodies  >78 publications with HBEGF and Intestine
 Heart Antibodies  >61 publications with HBEGF and Heart
 Embryonic Tissue Antibodies  >58 publications with HBEGF and Embryonic Tissue
 Bone Antibodies  >51 publications with HBEGF and Bone
 Eye Antibodies  >42 publications with HBEGF and Eye
 Prostate Antibodies  >28 publications with HBEGF and Prostate
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