Human IFNAR2 Recombinant Protein – Cat# MBS188454

Figure 1. Human IFNAR2 Protein, hFc Tag on SDS-PAGE under reducing condition.

IFNAR2 Human Recombinant Protein

Name: IFNAR2 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS188454
Price: 280 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS188454

The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins,… More details

$280 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

IFNAR2, Recombinant Protein

Full Product Name

Human IFNAR2 Protein, hFc Tag

Product Gene Name

IFNAR2 recombinant protein

Product Synonym Names

IFN-alpha-REC; IFN-R; IFNABR; IFNARB; IMD45

Sequence

IFNAR2 (Ile27-Arg 515) + hFc (Glu99-Ala 330)

Host

HEK293 cells

Form/Format

Lyophilized from sterile PBS, pH7.4. Normally 5%-8% trehalose is added as protectants before lyophilization.

Purity/Purification

Affinity purification

Preparation and Storage

Store at -80 degree C for 12 months (Avoid repeated freezing and thawing)

Molecular Weight

515

OMIM

gene 610424

3D Structure

ModBase 3D Structure for P48551

Origin

Human

Reconstitution

Reconstitute with deionized water

Tag

C-Human Fc

Other Notes

Small volumes of IFNAR2 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IFNAR2 purchase

MBS188454 is a recombinant protein targeting IFNAR2. Also known as Human IFNAR2 Protein, hFc Tag. Host: HEK293 cells.

Additional Details

NCBI/Uniprot data below describe general gene information for IFNAR2. It may not necessarily be applicable to this product.

NCBI GI #

1352466

NCBI GeneID

3455

NCBI Accession #

P48551.1

UniProt Primary Accession #

P48551

UniProt Secondary Accession #

Q15467; Q6FHD7; A8KAJ4; D3DSE8; D3DSE9

UniProt Related Accession #

P48551

NCBI Official Full Name

Interferon alpha/beta receptor 2

NCBI Official Synonym Full Names

interferon (alpha, beta and omega) receptor 2

NCBI Official Symbol

IFNAR2

NCBI Official Synonym Symbols

IFN-R; IFNABR; IFNARB; IFN-alpha-REC

UniProt Protein Name

Interferon alpha/beta receptor 2

UniProt Synonym Protein Names

Interferon alpha binding protein; Type I interferon receptor 2

Protein Family

Interferon alpha/beta receptor

UniProt Gene Name

IFNAR2

UniProt Synonym Gene Names

IFNABR; IFNARB; IFN-R-2; IFN-alpha binding protein; IFN-alpha/beta receptor 2

UniProt Entry Name

INAR2_HUMAN

NCBI Protein Information

interferon alpha/beta receptor 2; IFN-R-2; IFN-alpha/beta receptor 2; type I interferon receptor 2; interferon alpha binding protein; human interferon alpha/beta receptor; interferon-alpha/beta receptor beta chain

UniProt Comments for IFNAR2

IFNAR2: Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity. Belongs to the type II cytokine receptor family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 21q22.11

Cellular Component: extracellular space; integral to plasma membrane; plasma membrane; extracellular region

Molecular Function: protein binding; interferon-alpha/beta receptor activity; interferon-alpha/beta binding; protein kinase binding

Biological Process: regulation of transcription from RNA polymerase II promoter; cell proliferation; cell surface receptor linked signal transduction; cytokine and chemokine mediated signaling pathway; response to virus; JAK-STAT cascade

Disease: Hepatitis B Virus, Susceptibility To

Research Articles on IFNAR2

1. Results suggest that oxidative stress play an important role in the regulation of type I interferon receptors IFNAR1 and IFNAR2 in chronic hepatitis B virus (HBV) infection.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IFNAR2 recombinant protein

Reference Product	PubMed Publications
IFNA2 recombinant protein	>200 publications with IFNAR2 and IFNA2
IFNAR1 recombinant protein	>153 publications with IFNAR2 and IFNAR1
STAT1 recombinant protein	>35 publications with IFNAR2 and STAT1
STAT2 recombinant protein	>27 publications with IFNAR2 and STAT2
JAK1 recombinant protein	>26 publications with IFNAR2 and JAK1
TYK2 recombinant protein	>24 publications with IFNAR2 and TYK2
GNB2L1 recombinant protein	>2 publications with IFNAR2 and GNB2L1

Pathways associated with IFNAR2 recombinant protein

Products by Pathway	Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Downstream Signaling In Naive CD8+ T Cells Pathway antibodies	Downstream Signaling In Naive CD8+ T Cells Pathway Diagram
Hepatitis C Pathway antibodies	Hepatitis C Pathway Diagram
Hepatitis C Pathway antibodies	Hepatitis C Pathway Diagram
Herpes Simplex Infection Pathway antibodies	Herpes Simplex Infection Pathway Diagram
Herpes Simplex Infection Pathway antibodies	Herpes Simplex Infection Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Influenza A Pathway antibodies	Influenza A Pathway Diagram

Diseases associated with IFNAR2 recombinant protein

Disease Name	Pubmed Publications
Liver Diseases Antibodies	>32 publications with IFNAR2 and Liver Diseases
Carcinoma Antibodies	>25 publications with IFNAR2 and Carcinoma
Nervous System Diseases Antibodies	>17 publications with IFNAR2 and Nervous System Diseases
Adenocarcinoma Antibodies	>16 publications with IFNAR2 and Adenocarcinoma
Carcinoma, Hepatocellular Antibodies	>14 publications with IFNAR2 and Carcinoma, Hepatocellular
Inflammation Antibodies	>11 publications with IFNAR2 and Inflammation
Liver Neoplasms Antibodies	>9 publications with IFNAR2 and Liver Neoplasms
Necrosis Antibodies	>9 publications with IFNAR2 and Necrosis
Hepatitis B Antibodies	>8 publications with IFNAR2 and Hepatitis B
Cardiovascular Diseases Antibodies	>6 publications with IFNAR2 and Cardiovascular Diseases

Organs/Tissues associated with IFNAR2 recombinant protein

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>52 publications with IFNAR2 and Blood
Liver Antibodies	>34 publications with IFNAR2 and Liver
Lung Antibodies	>9 publications with IFNAR2 and Lung
Bone Marrow Antibodies	>7 publications with IFNAR2 and Bone Marrow
Uterus Antibodies	>7 publications with IFNAR2 and Uterus
Brain Antibodies	>6 publications with IFNAR2 and Brain
Spleen Antibodies	>6 publications with IFNAR2 and Spleen
Kidney Antibodies	>6 publications with IFNAR2 and Kidney
Lymph Node Antibodies	>3 publications with IFNAR2 and Lymph Node
Intestine Antibodies	>2 publications with IFNAR2 and Intestine