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IgG1 Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9147051

Recombinant Human IgG1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Pro100-Lys330) of human IgG1 Fc fused with a 6×His tag at the C-terminus. More details

$200 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
IgG1, Recombinant Protein
Full Product Name
Recombinant Human IgG1 Protein
Product Gene Name
IgG1 recombinant protein
Product Synonym Names
Human IgG; IGHG1; COB1; YAP; YAP2; YAP65; YKI; YAP1; human IgG (Fc)
Host
HEK293 cells
Form/Format
Liquid
Lyophilized from a 0.22 um filtered solution of PBS, pH 7.4.
Purity/Purification
> 95% by SDS-PAGE.
Preparation and Storage
Store the lyophilized protein at -20 to -80 degree C for 12 months. After reconstitution, the protein solution is stable at -20 degree C for 3 months, at 2-8 degree C for up to 1 week. Avoid repeated freeze/thaw cycles.
Ship: Ice Pack
Molecular Weight
150,000
Chromosome Location
Chromosome: 14; NC_000014.8 (106207810..106209407, complement). Location: 14q32.33
OMIM
147100
3D Structure
ModBase 3D Structure for P01857
Species
Human
Tag
C-His
Bioactivity
Measured by its binding ability in a functional ELISA. Immobilized Human Fc-gamma RII-a(CD32a) at 1 ug/mL (100 uL/well) can bind IgG1 Fc with a linear range of 0.156-3.47 ug/mL.

Product Categories/Family for IgG1 recombinant protein

Tool proteins
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

SDS-Page of IgG1 recombinant protein

Active Recombinant Human IgG1 Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 37kDa.
Human IgG1 Recombinant Protein – Cat# MBS9147051

Testing Data of IgG1 recombinant protein

Immobilized Human Fc-gamma RIIa( CD32a) at 1ug/mL (100 uL/well) can bind IgG1 Fc with a linear range of 0.156-3.47ug/mL.
Human IgG1 Recombinant Protein, Testing Data – Cat# MBS9147051

Other Notes

Small volumes of IgG1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IgG1 purchase

MBS9147051 is a recombinant protein targeting IgG1. Also known as Recombinant Human IgG1 Protein. Host: HEK293 cells.

Additional Details

NCBI/Uniprot data below describe general gene information for IgG1. It may not necessarily be applicable to this product.

NCBI GI #
121039
NCBI GeneID
3500
NCBI Accession #
P01857.1
UniProt Primary Accession #
P01857
UniProt Related Accession #
P01857
NCBI Official Full Name
Ig gamma-1 chain C region
NCBI Official Synonym Full Names
immunoglobulin heavy constant gamma 1 (G1m marker)
NCBI Official Symbol
IGHG1
UniProt Protein Name
Ig gamma-1 chain C region
Protein Family
Interleukin
UniProt Gene Name
IGHG1
UniProt Entry Name
IGHG1_HUMAN

UniProt Comments for IgG1

IGHG1: Defects in IGHG1 are a cause of multiple myeloma (MM). MM is a malignant tumor of plasma cells usually arising in the bone marrow and characterized by diffuse involvement of the skeletal system, hyperglobulinemia, Bence-Jones proteinuria and anemia. Complications of multiple myeloma are bone pain, hypercalcemia, renal failure and spinal cord compression. The aberrant antibodies that are produced lead to impaired humoral immunity and patients have a high prevalence of infection. Amyloidosis may develop in some patients. Multiple myeloma is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown significance (MGUS) to plasma cell leukemia. A chromosomal aberration involving IGHG1 is found in multiple myeloma. Translocation t(11;14)(q13;q32) with the IgH locus. Translocation t(11;14)(q13;q32) with CCND1; translocation t(4;14)(p16.3;q32.3) with FGFR3; translocation t(6;14)(p25;q32) with IRF4.

Protein type: Immunoglobulin superfamily

Chromosomal Location of Human Ortholog: 14q32.33

Cellular Component: extracellular space; extracellular region

Molecular Function: protein binding; antigen binding

Biological Process: innate immune response; complement activation, classical pathway; complement activation

Disease: Myeloma, Multiple
Show more

Research Articles on IgG1

1. The presence of IGHG1 in pancreatic cancer cells might constitute an important element responsible for tumor cell proliferation and immune evasion mechanisms.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IgG1 recombinant protein

 Reference Product  PubMed Publications
 IGKC recombinant protein  >1 publications with IgG1 and IGKC

Pathways associated with IgG1 recombinant protein

 Products by Pathway  Pathway Diagram
 Classical Antibody-mediated Complement Activation Pathway antibodies  Classical Antibody-mediated Complement Activation Pathway Diagram
 Complement Cascade Pathway antibodies  Complement Cascade Pathway Diagram
 Creation Of C4 And C2 Activators Pathway antibodies  Creation Of C4 And C2 Activators Pathway Diagram
 FCGR Activation Pathway antibodies  FCGR Activation Pathway Diagram
 Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway antibodies  Fcgamma Receptor (FCGR) Dependent Phagocytosis Pathway Diagram
 IL4-mediated Signaling Events Pathway antibodies  IL4-mediated Signaling Events Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 Initial Triggering Of Complement Pathway antibodies  Initial Triggering Of Complement Pathway Diagram
 Innate Immune System Pathway antibodies  Innate Immune System Pathway Diagram
 Regulation Of Actin Dynamics For Phagocytic Cup Formation Pathway antibodies  Regulation Of Actin Dynamics For Phagocytic Cup Formation Pathway Diagram

Organs/Tissues associated with IgG1 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >11 publications with IgG1 and Blood
 Lymph Antibodies  >2 publications with IgG1 and Lymph
 Lymph Node Antibodies  >2 publications with IgG1 and Lymph Node
 Intestine Antibodies  >2 publications with IgG1 and Intestine
 Skin Antibodies  >2 publications with IgG1 and Skin
 Bone Antibodies  >1 publications with IgG1 and Bone
 Bone Marrow Antibodies  >1 publications with IgG1 and Bone Marrow
 Thyroid Antibodies  >1 publications with IgG1 and Thyroid
 Pancreas Antibodies  >1 publications with IgG1 and Pancreas
 Uterus Antibodies  >1 publications with IgG1 and Uterus
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