IL-33 Recombinant Protein

Name: IL-33 Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS566239
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS566239

IL-33 is a member of the IL-1 family. It is involved in T helper type 2 response via the activation of its receptor ST2 (IL-1RL1) driving the production of Th2-associated cytokines. The stimulation of ST2 by IL-33 induces the NF-kappaB and MAPK pathways. The… More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

IL-33, Recombinant Protein

Full Product Name

IL-33 (human), (recombinant) (SuperPack)

Product Gene Name

IL-33 recombinant protein

Host

E Coli

Form/Format

Lyophilized. Contains PBS

Purity/Purification

>=95% (SDS-PAGE)
Purified by multi-step chromatography

Concentration

0.1mg/ml after reconstitution (lot specific)

Specificity

Binds to human ST2

Preparation and Storage

Stable for at least 6 months after receipt when stored at -20 degree C
Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -20 degree C
Shipping: Shipped on Blue Ice

Molecular Weight

30,759 Da

Chromosome Location

Chromosome: 9; NC_000009.11 (6215786..6257983). Location: 9p24.1

OMIM

608678

3D Structure

ModBase 3D Structure for O95760

Source Note

Untagged human IL-33 (aa 112-270)

Endotoxin

<0.1EU/ug purified protein (LAL test)

Reconstitution

Reconstitute with 100ul sterile distilled water. Further dilutions should be made with medium containing 5% fetal calf serum

Product Categories/Family for IL-33 recombinant protein

Cellular Analysis; Cell Signaling

Other Notes

Small volumes of IL-33 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL-33 purchase

MBS566239 is a recombinant protein targeting IL-33. Also known as IL-33 (human), (recombinant) (SuperPack). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for IL-33. It may not necessarily be applicable to this product.

NCBI GI #

314122337

NCBI GeneID

90865

NCBI Accession #

NP_001186570.1

UniProt Primary Accession #

O95760

UniProt Secondary Accession #

Q2YEJ5; B4DJ35; B4E1Q9; D3DRI5; E7EAX4

UniProt Related Accession #

O95760

GenBank Nucleotide #

NM_001199641.1

NCBI Official Full Name

interleukin-33 isoform 3

NCBI Official Synonym Full Names

interleukin 33

NCBI Official Symbol

IL33

NCBI Official Synonym Symbols

DVS27; IL1F11; NF-HEV; NFEHEV; C9orf26; RP11-575C20.2

UniProt Protein Name

Interleukin-33

UniProt Synonym Protein Names

Interleukin-1 family member 11; IL-1F11; Nuclear factor from high endothelial venules

UniProt Gene Name

IL33

UniProt Synonym Gene Names

C9orf26; IL1F11; NFHEV; IL-33; IL-1F11; NF-HEV

UniProt Entry Name

IL33_HUMAN

NCBI Protein Information

interleukin-33; IL-33; IL-1F11; DVS27-related protein; interleukin-1 family member 11; nuclear factor for high endothelial venules; nuclear factor from high endothelial venules

NCBI Summary for IL-33

IL33 (MIM 608678) is a member of the IL1 (see MIM 147760) family that potently drives production of T helper-2 (Th2)-associated cytokines (e.g., IL4; MIM 147780). IL33 is a ligand for IL33R (IL1RL1; MIM 601203), an IL1 family receptor that is selectively expressed on Th2 cells and mast cells (summary by Yagami et al., 2010 [PubMed 20926795]).[supplied by OMIM, Jan 2011]

UniProt Comments for IL-33

IL33: Cytokine that binds to and signals through IL1RL1/ST2 and its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Induces T-helper type 2-associated cytokines. Belongs to the IL-1 family. Highly divergent. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine

Chromosomal Location of Human Ortholog: 9p24.1

Cellular Component: extracellular space; transport vesicle; chromosome; nucleus

Molecular Function: protein binding; cytokine activity

Biological Process: negative regulation of T-helper 1 type immune response; T-helper 2 type immune response; positive regulation of T-helper 2 type immune response; transcription, DNA-dependent; positive regulation of interleukin-6 production; positive regulation of immunoglobulin secretion; negative regulation of leukocyte migration; positive regulation of interleukin-4 production; negative regulation of immunoglobulin secretion; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; negative regulation of interferon-gamma production; positive regulation of transcription from RNA polymerase II promoter; positive regulation of interleukin-13 production; positive regulation of interleukin-5 production; positive regulation of inflammatory response; positive regulation of macrophage activation

Research Articles on IL-33

1. Protein expression of interleukin 33 is detectable in macrophages of the chorioamniotic membranes in acute (but not chronic) chorioamnionitis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IL-33 recombinant protein

Reference Product	PubMed Publications
IL1RL1 recombinant protein	>94 publications with IL-33 and IL1RL1
CASP1 recombinant protein	>15 publications with IL-33 and CASP1
IL18 recombinant protein	>13 publications with IL-33 and IL18
IL25 recombinant protein	>9 publications with IL-33 and IL25
TSLP recombinant protein	>8 publications with IL-33 and TSLP
IL18R1 recombinant protein	>4 publications with IL-33 and IL18R1
CSF2 recombinant protein	>1 publications with IL-33 and CSF2

Pathways associated with IL-33 recombinant protein

Products by Pathway	Pathway Diagram
Cytosolic DNA-sensing Pathway antibodies	Cytosolic DNA-sensing Pathway Diagram
Cytosolic DNA-sensing Pathway antibodies	Cytosolic DNA-sensing Pathway Diagram
Influenza A Pathway antibodies	Influenza A Pathway Diagram
Influenza A Pathway antibodies	Influenza A Pathway Diagram

Diseases associated with IL-33 recombinant protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>112 publications with IL-33 and Inflammation
Asthma Antibodies	>57 publications with IL-33 and Asthma
Hypersensitivity, Immediate Antibodies	>55 publications with IL-33 and Hypersensitivity, Immediate
Lung Diseases Antibodies	>51 publications with IL-33 and Lung Diseases
Necrosis Antibodies	>36 publications with IL-33 and Necrosis
Cardiovascular Diseases Antibodies	>26 publications with IL-33 and Cardiovascular Diseases
Heart Diseases Antibodies	>14 publications with IL-33 and Heart Diseases
Neoplasms Antibodies	>14 publications with IL-33 and Neoplasms
Dermatitis, Atopic Antibodies	>10 publications with IL-33 and Dermatitis, Atopic
Hypertrophy Antibodies	>9 publications with IL-33 and Hypertrophy

Organs/Tissues associated with IL-33 recombinant protein

Organ/Tissue Name	Pubmed Publications
Lung Antibodies	>29 publications with IL-33 and Lung
Heart Antibodies	>22 publications with IL-33 and Heart
Skin Antibodies	>21 publications with IL-33 and Skin
Vascular Antibodies	>19 publications with IL-33 and Vascular
Muscle Antibodies	>14 publications with IL-33 and Muscle
Liver Antibodies	>12 publications with IL-33 and Liver
Intestine Antibodies	>10 publications with IL-33 and Intestine
Brain Antibodies	>6 publications with IL-33 and Brain
Connective Tissue Antibodies	>5 publications with IL-33 and Connective Tissue
Eye Antibodies	>5 publications with IL-33 and Eye