Human IL18 Recombinant Protein – Cat# MBS2580513

IL18 Human Recombinant Protein

Name: IL18 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS2580513
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2580513

Interleukin-18 (IL-18, also known as interferon-gamma inducing factor) is a proinflammatory cytokine that belongs to the IL-1 superfamily and is produced by macrophages and other cells. This cytokine can induce the IFN-gamma production of T cells. The… More details

$235 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

IL18, Recombinant Protein

Full Product Name

Recombinant Human IL18 N terminal protein (Avi,His tag)

Product Gene Name

IL18 recombinant protein

Product Synonym Names

IL18 N terminal; MGC; IL1F; IL-1F; IL18; IGIF; IL-18; IL-1g; IL1F4; GIF; Iboctadekin; IFN-gamma-inducing factor; IL-1 gamma; IL-1F4; Interferon gamma-inducing factor; Interferon-gamma-inducing factor; Interleukin 18; Interleukin-1 gamma; Interleukin-18; MGC12320; IFN gamma inducing factor; IL 1 gamma; IL 18; IL 1g; IL1 gamma; IL18 protein; IL1g; IL1gamma; ILIF4; Interferon gamma inducing factor; Interleukin 1 gamma; Interleukin 18 (interferon-gamma-inducing factor); Interleukin18

Sequence

Tyr37-Lys1 15

Host

E coli

Form/Format

Lyophilized from sterile PBS, pH 7.4.
Normally 5%-8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Purity/Purification

>95% as determined by reducing SDS-PAGE.

Preparation and Storage

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Molecular Weight

22,326 Da

Chromosome Location

Chromosome: 11; NC_000011.9 (112013974..112034840, complement). Location: 11q22.2-q22.3

OMIM

600953

3D Structure

ModBase 3D Structure for Q14116

Species

Human

Tag

C-Avi-His

Endotoxin

<10EU/mg of the protein as determined by the LAL method.

Conjugation

Biotinylated

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5mg/mL. Concentration is measured by UV-Vis.

Product Categories/Family for IL18 recombinant protein

Proteins; Recombinant Proteins; Others; Cancer; Immunology; Metabolism

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of IL18 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL18 purchase

MBS2580513 is a recombinant protein targeting IL18. Also known as Recombinant Human IL18 N terminal protein (Avi,His tag). Host: E coli.

Additional Details

NCBI/Uniprot data below describe general gene information for IL18. It may not necessarily be applicable to this product.

NCBI GI #

342349321

NCBI GeneID

3606

NCBI Accession #

NP_001230140.1

UniProt Primary Accession #

Q14116

UniProt Secondary Accession #

O75599; Q6FGY3; Q6WWJ7

UniProt Related Accession #

Q14116

GenBank Nucleotide #

NM_001243211.1

NCBI Official Full Name

interleukin-18 isoform 2 proprotein

NCBI Official Synonym Full Names

interleukin 18 (interferon-gamma-inducing factor)

NCBI Official Symbol

IL18

NCBI Official Synonym Symbols

IGIF; IL-18; IL-1g; IL1F4

UniProt Protein Name

Interleukin-18

UniProt Synonym Protein Names

Iboctadekin; Interferon gamma-inducing factor; IFN-gamma-inducing factor; Interleukin-1 gamma

Protein Family

Interleukin

UniProt Gene Name

IL18

UniProt Synonym Gene Names

IGIF; IL1F4; IL-18; IFN-gamma-inducing factor; IL-1 gamma

UniProt Entry Name

IL18_HUMAN

NCBI Protein Information

interleukin-18; IL-1 gamma; iboctadekin; interleukin-1 gamma; IFN-gamma-inducing factor

NCBI Summary for IL18

The protein encoded by this gene is a proinflammatory cytokine that augments natural killer cell activity in spleen cells, and stimulates interferon gamma production in T-helper type I cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Aug 2011]

UniProt Comments for IL18

IL18: Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. Belongs to the IL-1 family.

Protein type: Cytokine

Chromosomal Location of Human Ortholog: 11q22.2-q22.3

Cellular Component: extracellular space; extracellular region; cytosol

Molecular Function: protein binding; cytokine activity

Biological Process: positive regulation of granulocyte macrophage colony-stimulating factor production; positive regulation of NK T cell proliferation; natural killer cell activation; positive regulation of NF-kappaB import into nucleus; positive regulation of activated T cell proliferation; chemokine biosynthetic process; cell-cell signaling; lipopolysaccharide-mediated signaling pathway; granulocyte macrophage colony-stimulating factor biosynthetic process; angiogenesis; inflammatory response; regulation of cell adhesion; positive regulation of interleukin-17 production; positive regulation of natural killer cell proliferation; T-helper 1 type immune response; interleukin-2 biosynthetic process; T-helper 2 type immune response; MAPKKK cascade; interleukin-13 biosynthetic process; sleep; positive regulation of tissue remodeling; positive regulation of interferon-gamma production; interferon-gamma biosynthetic process; immune response; negative regulation of myoblast differentiation; positive regulation of inflammatory response

Research Articles on IL18

1. Circulating IL-18 levels were strongly associated with a range of established and novel risk factors but were not independently associated with risk of myocardial infarction or stroke.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IL18 recombinant protein

Reference Product	PubMed Publications
CASP1 recombinant protein	>443 publications with IL18 and CASP1
IL10 recombinant protein	>274 publications with IL18 and IL10
IL18R1 recombinant protein	>215 publications with IL18 and IL18R1
IL13 recombinant protein	>83 publications with IL18 and IL13
IL6 recombinant protein	>58 publications with IL18 and IL6
IL18RAP recombinant protein	>29 publications with IL18 and IL18RAP
IFNG recombinant protein	>20 publications with IL18 and IFNG
IL18BP recombinant protein	>17 publications with IL18 and IL18BP
IL1B recombinant protein	>17 publications with IL18 and IL1B
CCR5 recombinant protein	>15 publications with IL18 and CCR5

Pathways associated with IL18 recombinant protein

Products by Pathway	Pathway Diagram
African Trypanosomiasis Pathway antibodies	African Trypanosomiasis Pathway Diagram
African Trypanosomiasis Pathway antibodies	African Trypanosomiasis Pathway Diagram
Cellular Roles Of Anthrax Toxin Pathway antibodies	Cellular Roles Of Anthrax Toxin Pathway Diagram
Cytokine Signaling In Immune System Pathway antibodies	Cytokine Signaling In Immune System Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytosolic DNA-sensing Pathway antibodies	Cytosolic DNA-sensing Pathway Diagram
Cytosolic DNA-sensing Pathway antibodies	Cytosolic DNA-sensing Pathway Diagram
IL12 Signaling Mediated By STAT4 Pathway antibodies	IL12 Signaling Mediated By STAT4 Pathway Diagram
IL12-mediated Signaling Events Pathway antibodies	IL12-mediated Signaling Events Pathway Diagram

Diseases associated with IL18 recombinant protein

Disease Name	Pubmed Publications
Inflammation Antibodies	>1061 publications with IL18 and Inflammation
Necrosis Antibodies	>731 publications with IL18 and Necrosis
Neoplasms Antibodies	>500 publications with IL18 and Neoplasms
Lung Diseases Antibodies	>301 publications with IL18 and Lung Diseases
Kidney Diseases Antibodies	>251 publications with IL18 and Kidney Diseases
Hypersensitivity Antibodies	>243 publications with IL18 and Hypersensitivity
Arthritis, Rheumatoid Antibodies	>221 publications with IL18 and Arthritis, Rheumatoid
Liver Diseases Antibodies	>205 publications with IL18 and Liver Diseases
Heart Diseases Antibodies	>177 publications with IL18 and Heart Diseases
Hypersensitivity, Immediate Antibodies	>174 publications with IL18 and Hypersensitivity, Immediate

Organs/Tissues associated with IL18 recombinant protein

Organ/Tissue Name	Pubmed Publications
Liver Antibodies	>363 publications with IL18 and Liver
Lung Antibodies	>290 publications with IL18 and Lung
Skin Antibodies	>197 publications with IL18 and Skin
Brain Antibodies	>190 publications with IL18 and Brain
Bone Antibodies	>190 publications with IL18 and Bone
Heart Antibodies	>185 publications with IL18 and Heart
Intestine Antibodies	>149 publications with IL18 and Intestine
Bone Marrow Antibodies	>127 publications with IL18 and Bone Marrow
Muscle Antibodies	>120 publications with IL18 and Muscle
Connective Tissue Antibodies	>60 publications with IL18 and Connective Tissue