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IL37/IL23 Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS517122

Recombinant Human IL37/IL23 was expressed in E Coli cells. The protein accession number is Q9NZH6Member of the IL-1 family, IL-37 functions to curb excessive inflammation. In partnership with SMAD3, IL-37 suppresses, or reduces, proinflammatory cytokine… More details

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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
IL37/IL23, Recombinant Protein
Full Product Name
IL37/IL23
Product Gene Name
IL37/IL23 recombinant protein
Product Synonym Names
IL-37; IL-23; FIL1 zeta; IL-1X; Interleukin-1 family member 7; IL-1F7; Interleukin-1 homolog 4; IL-1H; IL-1H4; Interleukin-1 zeta; IL-1 zeta; Interleukin-1-related protein; IL-1RP1; Recombinant Human Interleukin-37/Interleukin-23 (IL37/IL23)
Host
E Coli
Form/Format
Lyophilized from a 0.2 um filtered solution in PBS and DTT
Preparation and Storage
The lyophilized protein is stable for at least one year from date of receipt at -70 degree C. Upon reconstitution, this cytokine can be stored in working aliquots at 2 degree -8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles.
Molecular Weight
24,126 Da
OMIM
605510
3D Structure
ModBase 3D Structure for Q9NZH6
Species
Human
Endotoxin Level
<1.0EU/ug of recombinant protein as determined by the LAL metho
Reconstitution
Reconstitute at 100ug/mL in sterile PBS
Dry Ice Shipment
Extra charge fee may add to your shipping cost as dry ice is required to ship this product.

Product Categories/Family for IL37/IL23 recombinant protein

Growth Factors
Applications Tested/Suitable for IL37/IL23 recombinant protein
Cell Assay

Testing Data of IL37/IL23 recombinant protein

IL37/IL23 Recombinant Protein – Cat# MBS517122

SDS-Page of IL37/IL23 recombinant protein

Purity: Recombinant Human IL37/IL23 resolved on a 15% SDS-PAGE gel under reducing conditions and stained with Coomassie Brilliant Blue G-250
IL37/IL23 Recombinant Protein, SDS-Page – Cat# MBS517122

Other Notes

Small volumes of IL37/IL23 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL37/IL23 purchase

MBS517122 is a recombinant protein targeting IL37/IL23. Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for IL37/IL23. It may not necessarily be applicable to this product.

NCBI GI #
27894302
NCBI GeneID
27178
NCBI Accession #
NP_775297.1
UniProt Primary Accession #
Q9NZH6
UniProt Secondary Accession #
Q56AP9; Q8TD04; Q8TD05; Q9HBF2; Q9HBF3; Q9UHA6; B5BU97
UniProt Related Accession #
Q9NZH6
GenBank Nucleotide #
NM_173205.1
NCBI Official Full Name
interleukin-37 isoform 5
NCBI Official Synonym Full Names
interleukin 37
NCBI Official Symbol
IL37
NCBI Official Synonym Symbols
FIL1; FIL1Z; IL-1H; IL-37; IL1F7; IL1H4; IL-1F7; IL-1H4; IL1RP1; IL-1RP1; FIL1(ZETA)
UniProt Protein Name
Interleukin-37
UniProt Synonym Protein Names
FIL1 zeta; IL-1X; Interleukin-1 family member 7; IL-1F7; Interleukin-1 homolog 4; IL-1H; IL-1H4; Interleukin-1 zeta; IL-1 zeta; Interleukin-1-related protein; IL-1RP1; Interleukin-23
UniProt Gene Name
IL37
UniProt Synonym Gene Names
FIL1Z; IL1F7; IL1H4; IL1RP1; IL-1F7; IL-1H; IL-1H4; IL-1 zeta; IL-1RP1; IL-37
UniProt Entry Name
IL37_HUMAN
NCBI Protein Information
interleukin-37; FIL1 zeta; IL-1 zeta; IL-1X protein; interleukin-23; interleukin 1, zeta; interleukin-1 homolog 4; interleukin-1 superfamily z; interleukin 1 family member 7; interleukin-1-related protein; IL-1F7b (IL-1H4, IL-1H, IL-1RP1); IL1F7 (canonica

NCBI Summary for IL37/IL23

The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
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UniProt Comments for IL37/IL23

IL37: Suppressor of innate inflammatory and immune responses involved in curbing excessive inflammation. This function requires SMAD3. Suppresses, or reduces, proinflammatory cytokine production, including IL1A and IL6, as well as CCL12, CSF1, CSF2, CXCL13, IL1B, IL23A and IL1RN, but spares anti-inflammatory cytokines. Inhibits dendritic cell activation. Belongs to the IL-1 family. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Cytokine

Chromosomal Location of Human Ortholog: 2q12-q14.1

Cellular Component: nucleoplasm; extracellular space; cytoplasm; extracellular region; nucleolus; nucleus; cytosol

Molecular Function: interleukin-1 receptor binding; cytokine activity

Biological Process: cytokine and chemokine mediated signaling pathway; immune response; inflammatory response
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Research Articles on IL37/IL23

1. functional polymorphism, IL1f7 rs3811047 G>A, might contribute to gastric cardiac adenocarcinoma (GCA) susceptibility.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IL37/IL23 recombinant protein

 Reference Product  PubMed Publications
 CASP1 recombinant protein  >1 publications with IL37/IL23 and CASP1
 SMAD3 recombinant protein  >1 publications with IL37/IL23 and SMAD3

Diseases associated with IL37/IL23 recombinant protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >11 publications with IL37/IL23 and Inflammation
 Disease Models, Animal Antibodies  >4 publications with IL37/IL23 and Disease Models, Animal
 Necrosis Antibodies  >4 publications with IL37/IL23 and Necrosis
 Liver Diseases Antibodies  >3 publications with IL37/IL23 and Liver Diseases
 Death Antibodies  >1 publications with IL37/IL23 and Death
 Heart Diseases Antibodies  >1 publications with IL37/IL23 and Heart Diseases
 Weight Loss Antibodies  >1 publications with IL37/IL23 and Weight Loss
 Drug-Induced Liver Injury Antibodies  >1 publications with IL37/IL23 and Drug-Induced Liver Injury

Organs/Tissues associated with IL37/IL23 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >1 publications with IL37/IL23 and Intestine
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