IL13 Recombinant Protein – Cat# MBS650568

~95% (SDS-PAGE)

Interleukin 13 (IL13) Recombinant Protein

Name: IL13 Recombinant Protein; Interleukin 13; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS650568
Price: 550 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS650568

Recombinant Interleukin-13 comprises a 112 amino acid fragment (21-132) corresponding to the mature Interleukin-13 110R form of the protein and is expressed in E. coli with an amino-terminal hexahistidine Interleukin-13 is a pleiotropic regulatory cytokine,… More details

$550 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Interleukin 13 (IL13), Recombinant Protein

Full Product Name

Interleukin 13, Recombinant, Human

Product Gene Name

IL13 recombinant protein

Host

Human, Recombinant, E Coli

Form/Format

Supplied as a liquid.

Purity/Purification

Highly Purified
Purified. 95% by SDS-PAGE.

Preparation and Storage

May be stored at 4 degree C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20 degree C. Aliquots are stable for at least 12 months at -20 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Molecular Weight

15,816 Da

Chromosome Location

Chromosome: 5; NC_000005.9 (131993865..131996801). Location: 5q31

OMIM

147683

3D Structure

ModBase 3D Structure for P35225

Product Categories/Family for IL13 recombinant protein

Growth Factors; Cytokines; Growth Factors-Interleukin

Applications Tested/Suitable for IL13 recombinant protein

ELISA (EL/EIA)

Application Notes for IL13 recombinant protein

Suitable for use in ELISA., , Recommended Dilution:, Optimal dilutions to be determined by the researcher.

Other Notes

Small volumes of IL13 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL13 purchase

MBS650568 is a recombinant protein targeting IL13. Also known as Interleukin 13, Recombinant, Human. Host: Human, Recombinant, E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for IL13. It may not necessarily be applicable to this product.

NCBI GI #

26787978

NCBI GeneID

3596

NCBI Accession #

NP_002179.2

UniProt Primary Accession #

P35225

UniProt Secondary Accession #

O43644; Q4VB52; Q9UDC7

UniProt Related Accession #

P35225; Q4VB50; Q4VB51; Q4VB53

GenBank Nucleotide #

NM_002188.2

NCBI Official Full Name

interleukin-13

NCBI Official Synonym Full Names

interleukin 13

NCBI Official Symbol

IL13

NCBI Official Synonym Symbols

ALRH; BHR1; P600; IL-13; MGC116786; MGC116788; MGC116789

UniProt Protein Name

Interleukin-13

Protein Family

Interleukin

UniProt Gene Name

IL13

UniProt Synonym Gene Names

NC30

UniProt Entry Name

IL13_HUMAN

NCBI Protein Information

interleukin-13; allergic rhinitis; OTTHUMP00000066048; Bronchial hyperresponsiveness-1 (bronchial asthma)

NCBI Summary for IL13

This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq]

UniProt Comments for IL13

Function: Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses.

Subunit structure: Interacts with IL13RA2.

Subcellular location: Secreted.

Involvement in disease: Defects in IL13 may be a cause of susceptibility to allergic rhinitis (ALRH) [

MIM:607154]. Allergic rhinitis is a common disease of complex inheritance and is characterized by mucosal inflammation caused by allergen exposure.

Sequence similarities: Belongs to the IL-4/IL-13 family.

Caution: It is uncertain whether Met-1 or Met-15 is the initiator.

Sequence caution: The sequence AAA36107.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAA83738.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAB01681.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAC03535.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAK53823.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence CAA48824.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Research Articles on IL13

1. Epigenetic regulation of the IL-13-induced human eotaxin-3 gene by CREB-binding protein-mediated histone 3 acetylation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IL13 recombinant protein

Reference Product	PubMed Publications
IL13RA1 recombinant protein	>272 publications with IL13 and IL13RA1
IL4R recombinant protein	>41 publications with IL13 and IL4R
IL13RA2 recombinant protein	>10 publications with IL13 and IL13RA2
VCAM1 recombinant protein	>4 publications with IL13 and VCAM1

Pathways associated with IL13 recombinant protein

Products by Pathway	Pathway Diagram
Asthma Pathway antibodies	Asthma Pathway Diagram
Asthma Pathway antibodies	Asthma Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokines And Inflammatory Response Pathway antibodies	Cytokines And Inflammatory Response Pathway Diagram
Fc Epsilon RI Signaling Pathway antibodies	Fc Epsilon RI Signaling Pathway Diagram
Fc Epsilon RI Signaling Pathway antibodies	Fc Epsilon RI Signaling Pathway Diagram
Glucocorticoid Receptor Regulatory Network Pathway antibodies	Glucocorticoid Receptor Regulatory Network Pathway Diagram
IL12 Signaling Mediated By STAT4 Pathway antibodies	IL12 Signaling Mediated By STAT4 Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram

Diseases associated with IL13 recombinant protein

Disease Name	Pubmed Publications
Hypersensitivity Antibodies	>984 publications with IL13 and Hypersensitivity
Inflammation Antibodies	>914 publications with IL13 and Inflammation
Asthma Antibodies	>895 publications with IL13 and Asthma
Hypersensitivity, Immediate Antibodies	>849 publications with IL13 and Hypersensitivity, Immediate
Lung Diseases Antibodies	>839 publications with IL13 and Lung Diseases
Respiratory Hypersensitivity Antibodies	>711 publications with IL13 and Respiratory Hypersensitivity
Neoplasms Antibodies	>382 publications with IL13 and Neoplasms
Eosinophilia Antibodies	>235 publications with IL13 and Eosinophilia
Fibrosis Antibodies	>228 publications with IL13 and Fibrosis
Bronchial Hyperreactivity Antibodies	>178 publications with IL13 and Bronchial Hyperreactivity

Organs/Tissues associated with IL13 recombinant protein

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>137 publications with IL13 and Brain
Bone Marrow Antibodies	>109 publications with IL13 and Bone Marrow
Mixed Antibodies	>58 publications with IL13 and Mixed
Testis Antibodies	>5 publications with IL13 and Testis