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Interleukin-19 (IL19) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS9022182

Cytokine that functions as an anti-inflammatory and proangiogenic factor. Polarizes adaptive immunity to an anti-inflammatory phenotype through induction of T-helper 2 responses by both down-regulation of IFN-gamma and up-regulation of IL4 and IL13. Produced… More details

$490 / 0.02 mg (E-Coli) +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Interleukin-19 (IL19), Recombinant Protein
Full Product Name
Recombinant Human Interleukin-19 (IL19), Biotinylated
Product Gene Name
IL19 recombinant protein
Product Synonym Names
IL-19; Melanoma differentiation-associated protein-like protein; NG.1
Sequence
LRRCLISTDM HHIEESFQEI KRAIQAKDTF PNVTILSTLE TLQIIKPLDV CCVTKNLLAF YVDRVFKDHQ EPNPKILRKI SSIANSFLYM QKTLRQCQEQ RQCHCRQEAT NATRVIHDNY DQLEVHAAAI KSLGELDVFL AWINKNHEVM FSA
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Form/Format
Liquid or Lyophilized powder
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.
Purity/Purification
Greater than 85% as determined by SDS-PAGE. (lot specific)
Preparation and Storage
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 degree C/-80 degree C. The shelf life of lyophilized form is 12 months at -20 degree C/-80 degree C.
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
Molecular Weight
23,079 Da
Tag Information
This protein contains an N-terminal tag and may also contain a C-terminal tag. Tag types are determined by various factors including tag-protein stability, please inquire for tag information.
Sterility
Sterile filter available upon request.
Endotoxin
Low endotoxin available upon request.
OMIM
605687
3D Structure
ModBase 3D Structure for Q9UHD0
Species
Homo sapiens (Human)
Tag
N-terminal MBP-tagged and C-terminal 6xHis-Avi-tagged
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL. We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20 degree C/-80 degree C. Our default final concentration of glycerol is 50%. Customers could use it as reference.

Product Categories/Family for IL19 recombinant protein

Immunology
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of IL19 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL19 purchase

MBS9022182 is a recombinant protein targeting IL19. Also known as Recombinant Human Interleukin-19 (IL19), Biotinylated. Host: E Coli or Yeast or Baculovirus or Mammalian Cell.

Additional Details

NCBI/Uniprot data below describe general gene information for IL19. It may not necessarily be applicable to this product.

NCBI GI #
30795208
NCBI GeneID
29949
NCBI Accession #
NP_037503.2
UniProt Primary Accession #
Q9UHD0
UniProt Secondary Accession #
Q5VUT3; Q96QR4; Q9NUA0; B6VEV9
UniProt Related Accession #
Q9UHD0
GenBank Nucleotide #
NM_013371.3
NCBI Official Full Name
interleukin-19 isoform 2
NCBI Official Synonym Full Names
interleukin 19
NCBI Official Symbol
IL19
NCBI Official Synonym Symbols
MDA1; NG.1; ZMDA1; IL-10C
UniProt Protein Name
Interleukin-19
UniProt Synonym Protein Names
Melanoma differentiation-associated protein-like protein; NG.1
Protein Family
Interleukin
UniProt Gene Name
IL19
UniProt Synonym Gene Names
ZMDA1; IL-19
UniProt Entry Name
IL19_HUMAN
NCBI Protein Information
interleukin-19; melanoma differentiation associated protein-like protein; melanoma differentiation-associated protein-like protein

NCBI Summary for IL19

The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described. [provided by RefSeq, Jul 2008]
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UniProt Comments for IL19

IL19: May play some important roles in inflammatory responses. Up-regulates IL-6 and TNF-alpha and induces apoptosis. Belongs to the IL-10 family.

Protein type: Secreted; Apoptosis; Cytokine; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 1q32.2

Cellular Component: extracellular space; extracellular region

Molecular Function: cytokine activity

Biological Process: apoptosis; positive regulation of JAK-STAT cascade; immune response; inflammatory response; signal transduction; interleukin-6 biosynthetic process
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Research Articles on IL19

1. IL-19 as a component of the IL-23/IL-17 axis strengthens the IL-17A action and might be a biomarker for the activity of this axis in chronic inflammatory disorders

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IL19 recombinant protein

 Reference Product  PubMed Publications
 IL13 recombinant protein  >4 publications with IL19 and IL13
 IL20RA recombinant protein  >3 publications with IL19 and IL20RA
 SOCS5 recombinant protein  >1 publications with IL19 and SOCS5
 IL23R recombinant protein  >1 publications with IL19 and IL23R
 IL23A recombinant protein  >1 publications with IL19 and IL23A

Pathways associated with IL19 recombinant protein

 Products by Pathway  Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 IL23-mediated Signaling Events Pathway antibodies  IL23-mediated Signaling Events Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram
 Jak-STAT Signaling Pathway antibodies  Jak-STAT Signaling Pathway Diagram

Diseases associated with IL19 recombinant protein

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >31 publications with IL19 and Inflammation
 Skin Diseases Antibodies  >24 publications with IL19 and Skin Diseases
 Disease Models, Animal Antibodies  >11 publications with IL19 and Disease Models, Animal
 Asthma Antibodies  >10 publications with IL19 and Asthma
 Carcinoma Antibodies  >6 publications with IL19 and Carcinoma
 Colitis Antibodies  >5 publications with IL19 and Colitis
 Hypersensitivity Antibodies  >5 publications with IL19 and Hypersensitivity
 Kidney Diseases Antibodies  >4 publications with IL19 and Kidney Diseases
 Respiratory Hypersensitivity Antibodies  >4 publications with IL19 and Respiratory Hypersensitivity
 Atherosclerosis Antibodies  >4 publications with IL19 and Atherosclerosis

Organs/Tissues associated with IL19 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Lung Antibodies  >10 publications with IL19 and Lung
 Mixed Antibodies  >1 publications with IL19 and Mixed
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