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LYN Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS553310

Lyn, a member of Src-family tyrosine kinases, is widely expressed in a variety of organs, tissues and cell types, including epithelial, hematopoietic and neuronal cells, and has an important role in signal transduction at the cytoplasmic face of the plasma… More details

$335 / 0.005 mg +1 FREE 8GB USB
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
LYN, Recombinant Protein
Full Product Name
Human LYN Recombinant
Product Gene Name
LYN recombinant protein
Product Synonym Names
LYN ; JTK8
Host
Insect Cells (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders)
Form/Format
Recombinant Human LYN was lyophilized from a 0.2 um filtered 20mM Tris,50mM NaCl, pH 8.0, 0.5mM PMSF.
Purity/Purification
>95%, as determined by SDS-PAGE
Preparation and Storage
The lyophilized protein is stable for at least 2 years from date of receipt at -20 degree C.
Upon reconstitution, this cytokine can be stored in working aliquots at 2 degree - 8 degree C for one month, or at -20 degree C for six months, with a carrier protein without detectable loss of activity.

Avoid repeated freeze/thaw cycles.
Molecular Weight
58,574 Da
OMIM
165120
3D Structure
ModBase 3D Structure for P07948
Domain
SH3,SH2
Host Note
DNA sequence encoding extracellular domain of Human LYN to a N-terminal GST tag was expressed in Insect cells.
Endotoxin
Endotoxin content was assayed using a LAL gel clot method.
Endotoxin level was found to be less than 0.1 ng/ug (1EU/ug).
Reconstitution
A quick spin of the vial followed by reconstitution in distilled water to a concentration not less than 0.1 mg/mL. This solution can then be diluted into other buffers.
Molecular Weight Note
Recombinant Human LYN is a monomer consisting of 736 amino acid residue, and migrates as an approximately 75 kDa protein under reducing conditions in SDS-PAGE.

Product Categories/Family for LYN recombinant protein

Receptors CD

Other Notes

Small volumes of LYN recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LYN purchase

MBS553310 is a recombinant protein targeting LYN. Also known as Human LYN Recombinant. Host: Insect Cells (Host protein expression may be lot-specific and can be subject to change during production, including bulk orders).

Additional Details

NCBI/Uniprot data below describe general gene information for LYN. It may not necessarily be applicable to this product.

NCBI GI #
162287326
NCBI GeneID
4067
NCBI Accession #
NP_001104567.1
UniProt Primary Accession #
P07948
UniProt Secondary Accession #
A0AVQ5
GenBank Nucleotide #
NM_001111097.2
NCBI Official Full Name
tyrosine-protein kinase Lyn isoform B
UniProt Protein Name
Tyrosine-protein kinase Lyn
UniProt Synonym Protein Names
Lck/Yes-related novel protein tyrosine kinase; V-yes-1 Yamaguchi sarcoma viral related oncogene homolog; p53Lyn; p56Lyn
Protein Family
Tyrosine-protein kinase
UniProt Gene Name
LYN
UniProt Synonym Gene Names
JTK8
UniProt Entry Name
LYN_HUMAN

NCBI Summary for LYN

This gene encodes a tyrosine protein kinase, which maybe involved in the regulation of mast cell degranulation, and erythroid differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

UniProt Comments for LYN

LYN: a tyrosine kinase of the Src family that plays a role in B cell antigen-receptor signaling.

Protein type: EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); Protein kinase, TK; Kinase, protein; Oncoprotein; TK group; Src family

Chromosomal Location of Human Ortholog: 8q13

Cellular Component: Golgi apparatus; mitochondrial crista; extrinsic to internal side of plasma membrane; mast cell granule; perinuclear region of cytoplasm; cytoplasm; postsynaptic density; plasma membrane; mitochondrial intermembrane space; nucleus; cytosol; lipid raft

Molecular Function: integrin binding; protein binding; enzyme binding; ubiquitin protein ligase binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; platelet-derived growth factor receptor binding; phosphoprotein binding; receptor signaling protein tyrosine kinase activity; glycosphingolipid binding; SH3 domain binding; ATP binding; receptor binding

Biological Process: regulation of mast cell degranulation; negative regulation of MAP kinase activity; central nervous system development; viral reproduction; response to toxin; positive regulation of B cell receptor signaling pathway; protein amino acid phosphorylation; response to organic cyclic substance; response to carbohydrate stimulus; regulation of B cell apoptosis; B cell receptor signaling pathway; erythrocyte differentiation; oligodendrocyte development; tolerance induction to self antigen; response to drug; platelet activation; negative regulation of immune response; response to sterol depletion; immune response-regulating cell surface receptor signaling pathway; response to amino acid stimulus; regulation of erythrocyte differentiation; histamine secretion by mast cell; T cell costimulation; leukocyte migration; cytokine secretion; transmembrane receptor protein tyrosine kinase signaling pathway; regulation of mast cell activation; axon guidance; regulation of cytokine secretion; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation; response to hormone stimulus; negative regulation of B cell proliferation; signal transduction; response to insulin stimulus; regulation of cytokine production; negative regulation of cell proliferation; regulation of cell adhesion mediated by integrin; platelet degranulation; B cell homeostasis; negative regulation of protein amino acid phosphorylation; positive regulation of cell proliferation; ephrin receptor signaling pathway; lipopolysaccharide-mediated signaling pathway; Fc receptor mediated inhibitory signaling pathway; Fc receptor mediated stimulatory signaling pathway; response to axon injury; inflammatory response; regulation of B cell receptor signaling pathway; regulation of protein amino acid phosphorylation; negative regulation of myeloid leukocyte differentiation; negative regulation of toll-like receptor 2 signaling pathway; positive regulation of phosphoinositide 3-kinase activity; positive regulation of cell motility; regulation of release of sequestered calcium ion into cytosol; positive regulation of tyrosine phosphorylation of STAT protein; negative regulation of toll-like receptor 4 signaling pathway; regulation of inflammatory response; cellular response to extracellular stimulus; innate immune response; blood coagulation; response to DNA damage stimulus; positive regulation of cell migration
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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