MARK4 Human Recombinant Protein

This gene encodes a member of the microtubule affinity-regulating kinase family. These protein kinases phosphorylate microtubule-associated proteins and regulate the transition between stable and dynamic microtubules. The encoded protein is associated with the centrosome throughout mitosis and may be involved in cell cycle control. Expression of this gene is a potential marker for cancer, and the encoded protein may also play a role in Alzheimer's disease. Pseudogenes of this gene are located on both the short and long arm of chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

MARK4: a member of the CAMKL family of protein kinases. Normally expressed in neural progenitors and is re-expressed in gliomas.

Protein type: Kinase, protein; EC 2.7.11.1; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); CAMK group; CAMKL family; MARK subfamily

Chromosomal Location of Human Ortholog: 19q13.3

Cellular Component: microtubule cytoskeleton; centrosome; neuron projection; microtubule organizing center; cytosol

Molecular Function: protein serine/threonine kinase activity; protein binding; gamma-tubulin binding; ubiquitin binding; microtubule binding; tau-protein kinase activity; ATP binding

Biological Process: nervous system development; positive regulation of programmed cell death; organelle organization and biogenesis; microtubule cytoskeleton organization and biogenesis; protein amino acid phosphorylation; microtubule bundle formation