Human NBL1 Recombinant Protein – Cat# MBS2581166

SDS-PAGE analysis of Human NBL1 proteins, 2ug/lane of Recombinant Human NBL1 proteins was resolved with SDS-PAGE under reducing conditions, showing bands at 55KD

NBL1 Human Recombinant Protein

Name: NBL1 Recombinant Protein; Human; MyBioSource
Brand: MyBioSource
SKU: MBS2581166
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS2581166

The Dan (Differential screening-selected gene aberrative in neuroblastoma, also known as N03) gene was first identified as the putative rat tumor suppressor gene and encodes a protein structurally related to Cerberus and Gremlin in the vertebrates. It is a… More details

$235 / 0.02 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

NBL1, Recombinant Protein

Full Product Name

Recombinant Human NBL1 Protein (Fc Tag)

Product Gene Name

NBL1 recombinant protein

Product Synonym Names

NBL; DAND; DAN; DAND1; NBL1; D1S1733E; DAN domain family member 1; DAND 1; Differential screening selected gene aberrant in neuroblastoma; MGC8972; NBL 1; Neuroblastoma candidate region suppression of tumorigenicity 1; Neuroblastoma suppression of tumorigenicity 1; Neuroblastoma suppressor of tumorigenicity 1; NO 3; NO3; Zinc finger protein DAN

Sequence

Ala17-Asp1 81

Host

Mammalian

Form/Format

Lyophilized from a 0.2um filtered solution in PBS with 5% Trehalose and 5% Mannitol.

Purity/Purification

>90% as determined by reducing SDS-PAGE.

Preparation and Storage

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80 degree C. Reconstituted protein solution can be stored at 4-8 degree C for 2-7 days. Aliquots of reconstituted samples are stable at < -20 degree C for 3 months.

Molecular Weight

19,277 Da

Chromosome Location

Chromosome: 1; NC_000001.10 (19969723..19984949). Location: 1p36.13

OMIM

600613

3D Structure

ModBase 3D Structure for P41271

Species

Human

Tag

C-Fc

Endotoxin

<1.0EU/mg of the protein as determined by the LAL method.

Reconstitution

It is recommended that sterile water be added to the vial to prepare a stock solution of 0.5mg/mL. Concentration is measured by UV-Vis.

Product Categories/Family for NBL1 recombinant protein

Proteins; Recombinant Proteins; Others; Signal Transduction; Cancer

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of NBL1 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NBL1 purchase

MBS2581166 is a recombinant protein targeting NBL1. Also known as Recombinant Human NBL1 Protein (Fc Tag). Host: Mammalian.

Additional Details

NCBI/Uniprot data below describe general gene information for NBL1. It may not necessarily be applicable to this product.

NCBI GI #

323276675

NCBI GeneID

4681

NCBI Accession #

NP_001191013.1

UniProt Primary Accession #

P41271

UniProt Secondary Accession #

Q5TGZ2; Q5U0N4; Q96L68; A3KFI7

UniProt Related Accession #

P41271

GenBank Nucleotide #

NM_001204084.2

NCBI Official Full Name

neuroblastoma suppressor of tumorigenicity 1 isoform 2

NCBI Official Synonym Full Names

neuroblastoma 1, DAN family BMP antagonist

NCBI Official Symbol

NBL1

NCBI Official Synonym Symbols

NB; DAN; NO3; DAND1; D1S1733E

UniProt Protein Name

Neuroblastoma suppressor of tumorigenicity 1

UniProt Synonym Protein Names

DAN domain family member 1; Protein N03; Zinc finger protein DAN

Protein Family

N-terminal-borealin-like protein

UniProt Gene Name

NBL1

UniProt Synonym Gene Names

DAN; DAND1

UniProt Entry Name

NBL1_HUMAN

NCBI Protein Information

neuroblastoma suppressor of tumorigenicity 1; DAN domain family member 1; differential screening-selected gene aberrant in neuroblastoma; neuroblastoma candidate region, suppression of tumorigenicity 1

NCBI Summary for NBL1

This gene product is the founding member of the evolutionarily conserved CAN (Cerberus and DAN) family of proteins, which contain a domain resembling the CTCK (C-terminal cystine knot-like) motif found in a number of signaling molecules. These proteins are secreted, and act as BMP (bone morphogenetic protein) antagonists by binding to BMPs and preventing them from interacting with their receptors. They may thus play an important role during growth and development. Alternatively spliced transcript variants have been identified for this gene. Read-through transcripts between this locus and the upstream mitochondrial inner membrane organizing system 1 gene (GeneID 440574) have been observed. [provided by RefSeq, May 2013]

UniProt Comments for NBL1

NBL1 iso2: Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process. Belongs to the DAN family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted, signal peptide; Tumor suppressor; Secreted

Chromosomal Location of Human Ortholog: 1p36.13

Cellular Component: extracellular space

Molecular Function: morphogen activity; protein homodimerization activity

Biological Process: nervous system development; determination of dorsal identity; positive regulation of neuron differentiation; neurite morphogenesis; negative regulation of BMP signaling pathway

Research Articles on NBL1

1. CDKN2A, GATA3, CREBBP, ITGA2, NBL1 and TGM4 were down-regulated in the prostate carcinoma glands compared to the corresponding normal glands

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with NBL1 recombinant protein

Reference Product	PubMed Publications
UBQLN1 recombinant protein	>2 publications with NBL1 and UBQLN1
BAG6 recombinant protein	>1 publications with NBL1 and BAG6

Organs/Tissues associated with NBL1 recombinant protein

Organ/Tissue Name	Pubmed Publications
Nerve Antibodies	>23 publications with NBL1 and Nerve
Bone Antibodies	>16 publications with NBL1 and Bone
Lung Antibodies	>5 publications with NBL1 and Lung
Embryonic Tissue Antibodies	>5 publications with NBL1 and Embryonic Tissue
Brain Antibodies	>4 publications with NBL1 and Brain
Eye Antibodies	>3 publications with NBL1 and Eye
Ganglia Antibodies	>3 publications with NBL1 and Ganglia
Prostate Antibodies	>3 publications with NBL1 and Prostate
Ovary Antibodies	>2 publications with NBL1 and Ovary
Testis Antibodies	>1 publications with NBL1 and Testis